2019

Puura K, Leppänen J, Salmelin R, Mäntymaa M, Luoma I, Latva R, Peltola M, Lehtimäki T, Tamminen T
Maternal and infant characteristics connected to shared pleasure in dyadic interaction.
Infant Ment Health J ;2019
PMID

Heiskanen JS, Ruohonen S, Rovio SP, Kytö V, Kähönen M, Lehtimäki T, Viikari JSA, Juonala M, Laitinen T, Tossavainen P, Jokinen E, Hutri-Kähönen N, Raitakari OT
Determinants of left ventricular diastolic function-The Cardiovascular Risk in Young Finns Study.
Echocardiography ;36(5)854-861, 2019
PMID

Saarinen A, Keltikangas-Järvinen L, Cloninger CR, Veijola J, Elovainio M, Lehtimäki T, Raitakari O, Hintsanen M
The relationship of dispositional compassion for others with depressive symptoms over a 15-year prospective follow-up.
J Affect Disord ;2019
PMID

Törnroos M, Elovainio M, Hintsa T, Hintsanen M, Pulkki-Råback L, Jokela M, Lehtimäki T, Raitakari OT, Keltikangas-Järvinen L
Personality traits and perceptions of organisational justice.
Int J Psychol ;54(3)414-422, 2019
PMID

Pehkonen J, Viinikainen J, Böckerman P, Pitkänen N, Lehtimäki T, Raitakari O
Health endowment and later-life outcomes in the labour market: Evidence using genetic risk scores and reduced-form models.
SSM Popul Health ;2019
PMID

Patel R, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Allayee H, Almgren P, Alver M, Baranova EV, Behlouli H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dubé MP, Dufresne L, Eriksson N, Foco L, Scholz M, Gijsberts CM, Glinge C, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kotti S, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, Van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Al Ali L, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Engström T, Fitzpatrick N, Fox K, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton-Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timm

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PMID



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PMID

Circ Genom Precis Med
2019
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PMID

Karjalainen JP, Mononen N, Hutri-Kähönen N, Lehtimäki M, Juonala M, Ala-Korpela M, Kähönen M, Raitakari O, Lehtimäki T
The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.
Sci Rep ;9(1)458, 2019
PMID

Nissinen SI, Roine A, Hokkinen L, Karjalainen M, Venäläinen M, Helminen H, Niemi R, Lehtimäki T, Rantanen T, Oksala N
Detection of Pancreatic Cancer by Urine Volatile Organic Compound Analysis.
Anticancer Res ;39(1)73-79, 2019
PMID

Vähämurto L, Pahkala K, Magnussen CG, Hutri-Kähönen N, Kähönen M, Laitinen T, Taittonen L, Tossavainen P, Lehtimäki T, Jokinen E, Telama R, Rönnemaa T, Viikari J, Juonala M, Raitakari OT
Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study.
Atherosclerosis ;2019
PMID

Sivertsen EA, Haug KBF, Kristianslund EK, Trøseid AS, Parkkari J, Lehtimäki T, Mononen N, Pasanen K, Bahr R
No Association Between Risk of Anterior Cruciate Ligament Rupture and Selected Candidate Collagen Gene Variants in Female Elite Athletes From High-Risk Team Sports.
Am J Sports Med ;47(1)52-58, 2019
PMID

Salokari E, Laukkanen JA, Lehtimaki T, Kurl S, Kunutsor S, Zaccardi F, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M, Nieminen T
The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality.
Eur J Prev Cardiol ;26(2)199-207, 2019
PMID

Böckerman P, Cawley J, Viinikainen J, Lehtimäki T, Rovio S, Seppälä I, Pehkonen J, Raitakari O
The effect of weight on labor market outcomes: An application of genetic instrumental variables.
Health Econ ;28(1)65-77, 2019
PMID

Patrakka O, Pienimäki JP, Tuomisto S, Ollikainen J, Lehtimäki T, Karhunen PJ, Martiskainen M
Oral Bacterial Signatures in Cerebral Thrombi of Patients With Acute Ischemic Stroke Treated With Thrombectomy.
J Am Heart Assoc ;8(11)e012330, 2019
PMID

Minkkinen M, Iverson GL, Kotilainen AK, Pauniaho SL, Mattila V, Lehtimäki T, Berghem K, Posti JP, Luoto TM
Prospective Validation of the Scandinavian Guidelines for Initial Management of Minimal, Mild, and Moderate Head Injuries in Adults.
J Neurotrauma ;2019
PMID

Jia Q, Han Y, Huang P, Woodward NC, Gukasyan J, Kettunen J, Ala-Korpela M, Anufrieva O, Wang Q, Perola M, Raitakari O, Lehtimäki T, Viikari J, Järvelin MR, Boehnke M, Laakso M, Mohlke KL, Fiehn O, Wang Z, Tang WHW, Hazen SL, Hartiala JA, Allayee H
Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease.
J Am Heart Assoc ;8(10)e011922, 2019
PMID

Rimpelä JM, Niiranen T, Jula A, Pörsti IH, Tikkakoski A, Havulinna A, Lehtimäki T, Salomaa V, Kontula KK, Hiltunen TP
Genome-wide association study of white-coat effect in hypertensive patients.
Blood Press ;2019
PMID

Latva-Rasku A, Honka MJ, Kullberg J, Mononen N, Lehtimäki T, Saltevo J, Kirjavainen AK, Saunavaara V, Iozzo P, Johansson L, Oscarsson J, Hannukainen JC, Nuutila P
The SGLT2 Inhibitor Dapagliflozin Reduces Liver Fat but Does Not Affect Tissue Insulin Sensitivity: A Randomized, Double-Blind, Placebo-Controlled Study With 8-Week Treatment in Type 2 Diabetes Patients.
Diabetes Care ;42(5)931-937, 2019
PMID

Juonala M, Pitkänen N, Tolonen S, Laaksonen M, Sievänen H, Jokinen E, Laitinen T, Sabin MA, Hutri-Kähönen N, Lehtimäki T, Taittonen L, Jula A, Loo BM, Impivaara O, Kähönen M, Magnussen CG, Viikari JSA, Raitakari OT
Childhood Exposure to Passive Smoking and Bone Health in Adulthood: The Cardiovascular Risk in Young Finns Study.
J Clin Endocrinol Metab ;104(6)2403-2411, 2019
PMID

van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I, Grarup N, Hall LM, Hemerich D, Lyytikäinen LP, Mei H, Müller-Nurasyid M, Prins BP, Robino A, Smith AV, Warren HR, Asselbergs FW, Boomsma DI, Caulfield MJ, Eijgelsheim M, Ford I, Hansen T, Harris TB, Heckbert SR, Hottenga JJ, Iorio A, Kors JA, Linneberg A, MacFarlane PW, Meitinger T, Nelson CP, Raitakari OT, Silva Aldana CT, Sinagra G, Sinner M, Soliman EZ, Stoll M, Uitterlinden A, van Duijn CM, Waldenberger M, Alonso A, Gasparini P, Gudnason V, Jamshidi Y, Kääb S, Kanters JK, Lehtimäki T, Munroe PB, Peters A, Samani NJ, Sotoodehnia N, Ulivi S, Wilson JG, de Geus EJC, Jukema JW, Stricker B, van der Harst P, de Bakker PIW, Isaacs A
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
Eur J Hum Genet ;27(6)952-962, 2019
PMID

Wu F, Juonala M, Pahkala K, Buscot MJ, Sabin MA, Pitkänen N, Rönnemaa T, Jula A, Lehtimäki T, Hutri-Kähönen N, Kähönen M, Laitinen T, Viikari JSA, Raitakari OT, Magnussen CG
Youth and Long-Term Dietary Calcium Intake With Risk of Impaired Glucose Metabolism and Type 2 Diabetes in Adulthood.
J Clin Endocrinol Metab ;104(6)2067-2074, 2019
PMID

Hernesniemi JA, Mahdiani S, Tynkkynen JA, Lyytikäinen LP, Mishra PP, Lehtimäki T, Eskola M, Nikus K, Antila K, Oksala N
Extensive phenotype data and machine learning in prediction of mortality in acute coronary syndrome - the MADDEC study.
Ann Med ;2019
PMID

Laaksonen J, Seppälä I, Raitoharju E, Mononen N, Lyytikäinen LP, Waldenberger M, Illig T, Lepistö M, Almusa H, Ellonen P, Hutri-Kähönen N, Juonala M, Kähönen M, Raitakari O, Salonen JT, Lehtimäki T
Discovery of mitochondrial DNA variants associated with genome-wide blood cell gene expression: a population-based mtDNA sequencing study.
Hum Mol Genet ;28(8)1381-1391, 2019
PMID

Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Dubé MP, Allayee H, Almgren P, Alver M, Baranova EV, Behlouli H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dufresne L, Eriksson N, Foco L, Gijsberts CM, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, Van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Fitzpatrick N, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton-Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott

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PMID



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PMID

Circ Genom Precis Med
2019
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PMID

Zwir I, Mishra P, Del-Val C, Gu CC, de Erausquin GA, Lehtimäki T, Cloninger CR
Uncovering the complex genetics of human personality: response from authors on the PGMRA Model.
Mol Psychiatry ;2019
PMID

Lea A, Subramaniam M, Ko A, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Mononen N, Raitakari OT, Ala-Korpela M, Pajukanta P, Zaitlen N, Ayroles JF
Genetic and environmental perturbations lead to regulatory decoherence.
Elife ;2019
PMID

Dobewall H, Savelieva K, Seppälä I, Knafo-Noam A, Hakulinen C, Elovainio M, Keltikangas-Järvinen L, Pulkki-Råback L, Raitakari OT, Lehtimäki T, Hintsanen M
Gene-environment correlations in parental emotional warmth and intolerance: genome-wide analysis over two generations of the Young Finns Study.
J Child Psychol Psychiatry ;60(3)277-285, 2019
PMID

Dörr M, Hamburg NM, Müller C, Smith NL, Gustafsson S, Lehtimäki T, Teumer A, Zeller T, Li X, Lind L, Raitakari OT, Völker U, Blankenberg S, McKnight B, Morris AP, Kähönen M, Lemaitre RN, Wild PS, Nauck M, Völzke H, Münzel T, Mitchell GF, Psaty BM, Lindgren CM, Larson MG, Felix SB, Ingelsson E, Lyytikäinen LP, Herrington D, Benjamin EJ, Schnabel RB
Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation.
Circ Genom Precis Med ;12(2)e002409, 2019
PMID

Savolainen AM, Karmi A, Immonen H, Soinio M, Saunavaara V, Pham T, Salminen P, Helmiö M, Ovaska J, Löyttyniemi E, Heiskanen MA, Lehtimäki T, Mari A, Nuutila P, Hannukainen JC
Physical Activity Associates with Muscle Insulin Sensitivity Postbariatric Surgery.
Med Sci Sports Exerc ;51(2)278-287, 2019
PMID

Pyysalo MJ, Mishra PP, Sundström K, Lehtimäki T, Karhunen PJ, Pessi T
Increased tooth brushing frequency is associated with reduced gingival pocket bacterial diversity in patients with intracranial aneurysms.
PeerJ ;2019
PMID

2018

Sivertsen EA, Haug KBF, Kristianslund EK, Trøseid AS, Parkkari J, Lehtimäki T, Mononen N, Pasanen K, Bahr R
No Association Between Risk of Anterior Cruciate Ligament Rupture and Selected Candidate Collagen Gene Variants in Female Elite Athletes From High-Risk Team Sports.
Am J Sports Med ;2018
PMID

Rinne P, Guillamat-Prats R, Rami M, Bindila L, Ring L, Lyytikäinen LP, Raitoharju E, Oksala N, Lehtimäki T, Weber C, van der Vorst EPC, Steffens S
Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation.
Arterioscler Thromb Vasc Biol ;38(11)2562-2575, 2018
PMID

Kettunen J, Ritchie SC, Anufrieva O, Lyytikäinen LP, Hernesniemi J, Karhunen PJ, Kuukasjärvi P, Laurikka J, Kähönen M, Lehtimäki T, Havulinna AS, Salomaa V, Männistö S, Ala-Korpela M, Perola M, Inouye M, Würtz P
Biomarker Glycoprotein Acetyls Is Associated With the Risk of a Wide Spectrum of Incident Diseases and Stratifies Mortality Risk in Angiography Patients.
Circ Genom Precis Med ;11(11)e002234, 2018
PMID

Sun C, Ponsonby AL, Carlin JB, Bui M, Magnussen CG, Burns TL, Lehtimaki T, Wardrop NH, Juonala M, Viikari JSA, Venn AJ, Raitakari OT, Dwyer T
Childhood adiposity, adult adiposity, and the ACE gene insertion/deletion polymorphism: evidence of gene-environment interaction effects on adult blood pressure and hypertension status in adulthood.
J Hypertens ;36(11)2168-2176, 2018
PMID

Oksman E, Rosenström T, Hintsanen M, Pulkki-Råback L, Viikari J, Lehtimäki T, Raitakari OT, Keltikangas-Järvinen L
A Longitudinal Multilevel Study of the "Social" Genotype and Diversity of the Phenotype.
Front Psychol ;2018
PMID

Campbell MD, Laitinen TT, Hughes A, Pahkala K, Juonala M, Kähönen M, Wong TY, Lehtimäki T, Hutri-Kähönen N, Raitakari OT, Tapp RJ
Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study.
J Am Heart Assoc ;7(20)e009487, 2018
PMID

Barrios C, Zierer J, Würtz P, Haller T, Metspalu A, Gieger C, Thorand B, Meisinger C, Waldenberger M, Raitakari O, Lehtimäki T, Otero S, Rodríguez E, Pedro-Botet J, Kähönen M, Ala-Korpela M, Kastenmüller G, Spector TD, Pascual J, Menni C
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
Sci Rep ;8(1)15249, 2018
PMID

Rinne P, Lyytikäinen LP, Raitoharju E, Kadiri JJ, Kholova I, Kähönen M, Lehtimäki T, Oksala N
Pro-opiomelanocortin and its Processing Enzymes Associate with Plaque Stability in Human Atherosclerosis - Tampere Vascular Study.
Sci Rep ;8(1)15078, 2018
PMID

Zwir I, Arnedo J, Del-Val C, Pulkki-Råback L, Konte B, Yang SS, Romero-Zaliz R, Hintsanen M, Cloninger KM, Garcia D, Svrakic DM, Rozsa S, Martinez M, Lyytikäinen LP, Giegling I, Kähönen M, Hernandez-Cuervo H, Seppälä I, Raitoharju E, de Erausquin GA, Raitakari O, Rujescu D, Postolache TT, Sung J, Keltikangas-Järvinen L, Lehtimäki T, Cloninger CR
Uncovering the complex genetics of human character.
Mol Psychiatry ;2018
PMID

Zwir I, Arnedo J, Del-Val C, Pulkki-Råback L, Konte B, Yang SS, Romero-Zaliz R, Hintsanen M, Cloninger KM, Garcia D, Svrakic DM, Rozsa S, Martinez M, Lyytikäinen LP, Giegling I, Kähönen M, Hernandez-Cuervo H, Seppälä I, Raitoharju E, de Erausquin GA, Raitakari O, Rujescu D, Postolache TT, Sung J, Keltikangas-Järvinen L, Lehtimäki T, Cloninger CR
Uncovering the complex genetics of human temperament.
Mol Psychiatry ;2018
PMID

Viinikainen J, Bryson A, Böckerman P, Elovainio M, Pitkänen N, Pulkki-Råback L, Lehtimäki T, Raitakari O, Pehkonen J
Does education protect against depression? Evidence from the Young Finns Study using Mendelian randomization.
Prev Med ;2018
PMID

Dobewall H, Savelieva K, Seppälä I, Knafo-Noam A, Hakulinen C, Elovainio M, Keltikangas-Järvinen L, Pulkki-Råback L, Raitakari OT, Lehtimäki T, Hintsanen M
Gene-environment correlations in parental emotional warmth and intolerance: genome-wide analysis over two generations of the Young Finns Study.
J Child Psychol Psychiatry ;2018
PMID

Salokari E, Laukkanen JA, Lehtimaki T, Kurl S, Kunutsor S, Zaccardi F, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M, Nieminen T
The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality.
Eur J Prev Cardiol ;2018
PMID

Gluschkoff K, Pulkki-Råback L, Elovainio M, Saarinen A, Tammelin T, Hirvensalo M, Lehtimäki T, Keltikangas-Järvinen L, Raitakari O, Hintsanen M
Is It Good To Be Good? Dispositional Compassion and Health Behaviors.
Ann Behav Med ;2018
PMID

Haworth S, Shungin D, van der Tas JT, Vucic S, Medina-Gomez C, Yakimov V, Feenstra B, Shaffer JR, Lee MK, Standl M, Thiering E, Wang C, Bønnelykke K, Waage J, Jessen LE, Nørrisgaard PE, Joro R, Seppälä I, Raitakari O, Dudding T, Grgic O, Ongkosuwito E, Vierola A, Eloranta AM, West NX, Thomas SJ, McNeil DW, Levy SM, Slayton R, Nohr EA, Lehtimäki T, Lakka T, Bisgaard H, Pennell C, Kühnisch J, Marazita ML, Melbye M, Geller F, Rivadeneira F, Wolvius EB, Franks PW, Johansson I, Timpson NJ
Consortium-based genome-wide meta-analysis for childhood dental caries traits.
Hum Mol Genet ;27(17)3113-3127, 2018
PMID

Roselli C, Chaffin MD, Weng LC, Aeschbacher S, Ahlberg G, Albert CM, Almgren P, Alonso A, Anderson CD, Aragam KG, Arking DE, Barnard J, Bartz TM, Benjamin EJ, Bihlmeyer NA, Bis JC, Bloom HL, Boerwinkle E, Bottinger EB, Brody JA, Calkins H, Campbell A, Cappola TP, Carlquist J, Chasman DI, Chen LY, Chen YI, Choi EK, Choi SH, Christophersen IE, Chung MK, Cole JW, Conen D, Cook J, Crijns HJ, Cutler MJ, Damrauer SM, Daniels BR, Darbar D, Delgado G, Denny JC, Dichgans M, Dörr M, Dudink EA, Dudley SC, Esa N, Esko T, Eskola M, Fatkin D, Felix SB, Ford I, Franco OH, Geelhoed B, Grewal RP, Gudnason V, Guo X, Gupta N, Gustafsson S, Gutmann R, Hamsten A, Harris TB, Hayward C, Heckbert SR, Hernesniemi J, Hocking LJ, Hofman A, Horimoto ARVR, Huang J, Huang PL, Huffman J, Ingelsson E, Ipek EG, Ito K, Jimenez-Conde J, Johnson R, Jukema JW, Kääb S, Kähönen M, Kamatani Y, Kane JP, Kastrati A, Kathiresan S, Katschnig-Winter P, Kavousi M, Kessler T, Kietselaer BL, Kirc

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PMID



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PMID

Nat Genet
50(9)
1225-1233 ;, 2018
PMID

Nissinen MJ, Pitkänen N, Simonen P, Gylling H, Viikari J, Raitakari O, Lehtimäki T, Juonala M, Pakarinen MP
Genetic polymorphism of sterol transporters in children with future gallstones.
Dig Liver Dis ;50(9)954-960, 2018
PMID

Dobewall H, Hakulinen C, Keltikangas-Järvinen L, Pulkki-Råback L, Seppälä I, Lehtimäki T, Raitakari OT, Hintsanen M
Oxytocin receptor gene (OXTR) variant rs1042778 moderates the influence of family environment on changes in perceived social support over time.
J Affect Disord ;2018
PMID

van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF, Kerr KF, Krijthe BP, Lyytikäinen LP, Müller C, Müller-Nurasyid M, Nolte IM, Padmanabhan S, Ritchie MD, Robino A, Smith AV, Steri M, Tanaka T, Teumer A, Trompet S, Ulivi S, Verweij N, Yin X, Arnar DO, Asselbergs FW, Bader JS, Barnard J, Bis J, Blankenberg S, Boerwinkle E, Bradford Y, Buckley BM, Chung MK, Crawford D, den Hoed M, Denny JC, Dominiczak AF, Ehret GB, Eijgelsheim M, Ellinor PT, Felix SB, Franco OH, Franke L, Harris TB, Holm H, Ilaria G, Iorio A, Kähönen M, Kolcic I, Kors JA, Lakatta EG, Launer LJ, Lin H, Lin HJ, Loos RJF, Lubitz SA, Macfarlane PW, Magnani JW, Leach IM, Meitinger T, Mitchell BD, Munzel T, Papanicolaou GJ, Peters A, Pfeufer A, Pramstaller PP, Raitakari OT, Rotter JI, Rudan I, Samani NJ, Schlessinger D, Silva Aldana CT, Sinner MF, Smith JD, Snieder H, Soliman EZ, Spector TD, Stott DJ, Strauch K, Taraso

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PMID

Nat Commun
9(1)
2904 ;, 2018
PMID

Prins BP, Mead TJ, Brody JA, Sveinbjornsson G, Ntalla I, Bihlmeyer NA, van den Berg M, Bork-Jensen J, Cappellani S, Van Duijvenboden S, Klena NT, Gabriel GC, Liu X, Gulec C, Grarup N, Haessler J, Hall LM, Iorio A, Isaacs A, Li-Gao R, Lin H, Liu CT, Lyytikäinen LP, Marten J, Mei H, Müller-Nurasyid M, Orini M, Padmanabhan S, Radmanesh F, Ramirez J, Robino A, Schwartz M, van Setten J, Smith AV, Verweij N, Warren HR, Weiss S, Alonso A, Arnar DO, Bots ML, de Boer RA, Dominiczak AF, Eijgelsheim M, Ellinor PT, Guo X, Felix SB, Harris TB, Hayward C, Heckbert SR, Huang PL, Jukema JW, Kähönen M, Kors JA, Lambiase PD, Launer LJ, Li M, Linneberg A, Nelson CP, Pedersen O, Perez M, Peters A, Polasek O, Psaty BM, Raitakari OT, Rice KM, Rotter JI, Sinner MF, Soliman EZ, Spector TD, Strauch K, Thorsteinsdottir U, Tinker A, Trompet S, Uitterlinden A, Vaartjes I, van der Meer P, Völker U, Völzke H, Waldenberger M, Wilson JG, Xie Z, Asselbergs FW, Dörr M, van Duijn CM

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PMID

Genome Biol
19(1)
87 ;, 2018
PMID

Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE, Dedoussis GV, Lemaitre RN, Wojczynski MK, Männistö S, Ngwa JS, Kho M, Ahluwalia TS, Pervjakova N, Houston DK, Bouchard C, Huang T, Orho-Melander M, Frazier-Wood AC, Mook-Kanamori DO, Pérusse L, Pennell CE, de Vries PS, Voortman T, Li O, Kanoni S, Rose LM, Lehtimäki T, Zhao JH, Feitosa MF, Luan J, McKeown NM, Smith JA, Hansen T, Eklund N, Nalls MA, Rankinen T, Huang J, Hernandez DG, Schulz CA, Manichaikul A, Li-Gao R, Vohl MC, Wang CA, van Rooij FJA, Shin J, Kalafati IP, Day F, Ridker PM, Kähönen M, Siscovick DS, Langenberg C, Zhao W, Astrup A, Knekt P, Garcia M, Rao DC, Qi Q, Ferrucci L, Ericson U, Blangero J, Hofman A, Pausova Z, Mikkilä V, Wareham NJ, Kardia SLR, Pedersen O, Jula A, Curran JE, Zillikens MC, Viikari JS, Forouhi NG, Ordovás JM, Lieske JC, Rissanen H, Uitterlinden AG, Raitakari OT, Kiefte-de Jong JC, Dupuis J, Rotter JI, North KE, Scott RA, Provi

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PMID

Mol Psychiatry
2018
;
PMID

Taipale T, Seppälä I, Raitoharju E, Mononen N, Lyytikäinen LP, Illig T, Waldenberger M, Juonala M, Hutri-Kähönen N, Oksala N, Kähönen M, Raitakari O, Lehtimäki T
Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study.
Sci Rep ;8(1)10358, 2018
PMID

Rimpelä JM, Pörsti IH, Jula A, Lehtimäki T, Niiranen TJ, Oikarinen L, Porthan K, Tikkakoski A, Virolainen J, Kontula KK, Hiltunen TP
Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients.
BMC Med Genet ;19(1)110, 2018
PMID

Akbaraly T, Würtz P, Singh-Manoux A, Shipley MJ, Haapakoski R, Lehto M, Desrumaux C, Kähönen M, Lehtimäki T, Mikkilä V, Hingorani A, Humphries SE, Kangas AJ, Soininen P, Raitakari O, Ala-Korpela M, Kivimäki M
Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.
Sci Rep ;8(1)8620, 2018
PMID

Buscot MJ, Thomson RJ, Juonala M, Sabin MA, Burgner DP, Lehtimäki T, Hutri-Kähönen N, Viikari JSA, Raitakari OT, Magnussen CG
Distinct child-to-adult body mass index trajectories are associated with different levels of adult cardiometabolic risk.
Eur Heart J ;39(24)2263-2270, 2018
PMID

Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, Beiser A, Larson MG, Sääksjärvi K, Shipley MJ, Singh-Manoux A, Gerszten RE, Wang TJ, Havulinna AS, Würtz P, Fischer K, Demirkan A, Ikram MA, Amin N, Lehtimäki T, Kähönen M, Perola M, Metspalu A, Kangas AJ, Soininen P, Ala-Korpela M, Vasan RS, Kivimäki M, van Duijn CM, Seshadri S, Salomaa V
Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts.
Alzheimers Dement ;14(6)723-733, 2018
PMID

Vakhitov D, Tuomisto S, Martiskainen M, Korhonen J, Pessi T, Salenius JP, Suominen V, Lehtimäki T, Karhunen PJ, Oksala N
Bacterial signatures in thrombus aspirates of patients with lower limb arterial and venous thrombosis.
J Vasc Surg ;67(6)1902-1907, 2018
PMID

Bhosale SD, Moulder R, Venäläinen MS, Koskinen JS, Pitkänen N, Juonala MT, Kähönen MAP, Lehtimäki TJ, Viikari JSA, Elo LL, Goodlett DR, Lahesmaa R, Raitakari OT
Serum Proteomic Profiling to Identify Biomarkers of Premature Carotid Atherosclerosis.
Sci Rep ;8(1)9209, 2018
PMID

Venäläinen MK, Roine AN, Häkkinen MR, Vepsäläinen JJ, Kumpulainen PS, Kiviniemi MS, Lehtimäki T, Oksala NK, Rantanen TK
Altered Polyamine Profiles in Colorectal Cancer.
Anticancer Res ;38(6)3601-3607, 2018
PMID

Sliz E, Sebert S, Würtz P, Kangas AJ, Soininen P, Lehtimäki T, Kähönen M, Viikari J, Männikkö M, Ala-Korpela M, Raitakari OT, Kettunen J
NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects.
Hum Mol Genet ;27(12)2214-2223, 2018
PMID

Solismaa A, Kampman O, Lyytikäinen LP, Seppälä N, Viikki M, Mononen N, Lehtimäki T, Leinonen E
Genetic Polymorphisms Associated With Constipation and Anticholinergic Symptoms in Patients Receiving Clozapine.
J Clin Psychopharmacol ;38(3)193-199, 2018
PMID

Andre K, Kampman O, Viikki M, Setälä-Soikkeli E, Illi A, Mononen N, Lehtimäki T, Leinonen E
BDNF and NRG1 polymorphisms and temperament in selective serotonin reuptake inhibitor-treated patients with major depression.
Acta Neuropsychiatr ;30(3)168-174, 2018
PMID

Lin H, van Setten J, Smith AV, Bihlmeyer NA, Warren HR, Brody JA, Radmanesh F, Hall L, Grarup N, Müller-Nurasyid M, Boutin T, Verweij N, Lin HJ, Li-Gao R, van den Berg ME, Marten J, Weiss S, Prins BP, Haessler J, Lyytikäinen LP, Mei H, Harris TB, Launer LJ, Li M, Alonso A, Soliman EZ, Connell JM, Huang PL, Weng LC, Jameson HS, Hucker W, Hanley A, Tucker NR, Chen YI, Bis JC, Rice KM, Sitlani CM, Kors JA, Xie Z, Wen C, Magnani JW, Nelson CP, Kanters JK, Sinner MF, Strauch K, Peters A, Waldenberger M, Meitinger T, Bork-Jensen J, Pedersen O, Linneberg A, Rudan I, de Boer RA, van der Meer P, Yao J, Guo X, Taylor KD, Sotoodehnia N, Rotter JI, Mook-Kanamori DO, Trompet S, Rivadeneira F, Uitterlinden A, Eijgelsheim M, Padmanabhan S, Smith BH, Völzke H, Felix SB, Homuth G, Völker U, Mangino M, Spector TD, Bots ML, Perez M, Kähönen M, Raitakari OT, Gudnason V, Arking DE, Munroe PB, Psaty BM, van Duijn CM, Benjamin EJ, Rosand J, Samani NJ, Hansen T, Kääb S, Pol

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PMID

Circ Genom Precis Med
11(5)
e002037 ;, 2018
PMID

Hernesniemi JA, Heiskanen J, Ruohonen S, Kartiosuo N, Hutri-Kähönen N, Kähönen M, Jokinen E, Tossavainen P, Kallio M, Laitinen T, Lehtimäki T, Viikari JSA, Juonala M, Raitakari OT
Aortic sinus diameter in middle age is associated with body size in young adulthood.
Heart ;104(9)773-778, 2018
PMID

Zhou A, Taylor AE, Karhunen V, Zhan Y, Rovio SP, Lahti J, Sjögren P, Byberg L, Lyall DM, Auvinen J, Lehtimäki T, Kähönen M, Hutri-Kähönen N, Perälä MM, Michaëlsson K, Mahajan A, Lind L, Power C, Eriksson JG, Raitakari OT, Hägg S, Pedersen NL, Veijola J, Järvelin MR, Munafò MR, Ingelsson E, Llewellyn DJ, Hyppönen E
Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants.
Sci Rep ;8(1)7526, 2018
PMID

Erhart G, Lamina C, Lehtimäki T, Marques-Vidal P, Kähönen M, Vollenweider P, Raitakari OT, Waeber G, Thorand B, Strauch K, Gieger C, Meitinger T, Peters A, Kronenberg F, Coassin S
Genetic Factors Explain a Major Fraction of the 50% Lower Lipoprotein(a) Concentrations in Finns.
Arterioscler Thromb Vasc Biol ;38(5)1230-1241, 2018
PMID

Khan N, Lyytikäinen LP, Khan J, Seppälä I, Lehtomäki A, Kuorilehto T, Suominen V, Lehtimäki T, Oksala N
Extended Serum Lipid Profile Predicting Long-Term Survival in Patients Treated for Abdominal Aortic Aneurysms.
World J Surg ;42(4)1200-1207, 2018
PMID

Koivistoinen T, Lyytikäinen LP, Aatola H, Luukkaala T, Juonala M, Viikari J, Lehtimäki T, Raitakari OT, Kähönen M, Hutri-Kähönen N
Pulse Wave Velocity Predicts the Progression of Blood Pressure and Development of Hypertension in Young Adults.
Hypertension ;71(3)451-456, 2018
PMID

Tolonen S, Sievänen H, Hirvensalo M, Laaksonen M, Mikkilä V, Pälve K, Lehtimäki T, Raitakari O, Kähönen M
Higher step count is associated with greater bone mass and strength in women but not in men.
Arch Osteoporos ;13(1)20, 2018
PMID

Saarinen A, Hintsanen M, Hakulinen C, Pulkki-Råback L, Lehtimäki T, Raitakari O, Keltikangas-Järvinen L
The co-occurrence between depressive symptoms and paranoid ideation: A population-based longitudinal study.
J Affect Disord ;2018
PMID

Saarinen A, Rosenström T, Hintsanen M, Hakulinen C, Pulkki-Råback L, Lehtimäki T, Raitakari OT, Cloninger CR, Keltikangas-Järvinen L
Longitudinal associations of temperament and character with paranoid ideation: A population-based study.
Psychiatry Res ;2018
PMID

Immonen H, Hannukainen JC, Kudomi N, Pihlajamäki J, Saunavaara V, Laine J, Salminen P, Lehtimäki T, Pham T, Iozzo P, Nuutila P
Increased Liver Fatty Acid Uptake Is Partly Reversed and Liver Fat Content Normalized After Bariatric Surgery.
Diabetes Care ;41(2)368-371, 2018
PMID

Wu F, Juonala M, Pitkänen N, Jula A, Lehtimäki T, Sabin MA, Pahkala K, Hutri-Kähönen N, Kähönen M, Laitinen T, Viikari JSA, Magnussen CG, Raitakari OT
Both youth and long-term vitamin D status is associated with risk of type 2 diabetes mellitus in adulthood: a cohort study.
Ann Med ;50(1)74-82, 2018
PMID

McKeown NM, Dashti HS, Ma J, Haslam DE, Kiefte-de Jong JC, Smith CE, Tanaka T, Graff M, Lemaitre RN, Rybin D, Sonestedt E, Frazier-Wood AC, Mook-Kanamori DO, Li Y, Wang CA, Leermakers ETM, Mikkilä V, Young KL, Mukamal KJ, Cupples LA, Schulz CA, Chen TA, Li-Gao R, Huang T, Oddy WH, Raitakari O, Rice K, Meigs JB, Ericson U, Steffen LM, Rosendaal FR, Hofman A, Kähönen M, Psaty BM, Brunkwall L, Uitterlinden AG, Viikari J, Siscovick DS, Seppälä I, North KE, Mozaffarian D, Dupuis J, Orho-Melander M, Rich SS, de Mutsert R, Qi L, Pennell CE, Franco OH, Lehtimäki T, Herman MA
Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis.
Diabetologia ;61(2)317-330, 2018
PMID

Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM, Kilpeläinen TO, Wojczynski MK, Richardson K, Nalls MA, Schulz CA, Liu Y, Frazier-Wood AC, van Eekelen E, Wang C, de Vries PS, Mikkilä V, Rohde R, Psaty BM, Hansen T, Feitosa MF, Lai CQ, Houston DK, Ferruci L, Ericson U, Wang Z, de Mutsert R, Oddy WH, de Jonge EAL, Seppälä I, Justice AE, Lemaitre RN, Sørensen TIA, Province MA, Parnell LD, Garcia ME, Bandinelli S, Orho-Melander M, Rich SS, Rosendaal FR, Pennell CE, Kiefte-de Jong JC, Kähönen M, Young KL, Pedersen O, Aslibekyan S, Rotter JI, Mook-Kanamori DO, Zillikens MC, Raitakari OT, North KE, Overvad K, Arnett DK, Hofman A, Lehtimäki T, Tjønneland A, Uitterlinden AG, Rivadeneira F, Franco OH, German JB, Siscovick DS, Cupples LA, Ordovás JM
Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.
Mol Nutr Food Res ;2018
PMID

Tapp RJ, Hughes AD, Kähönen M, Wong TY, Witt N, Lehtimäki T, Hutri-Kähönen N, Sahota P, Juonala M, Raitakari OT
Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study.
J Am Heart Assoc ;2018
PMID

Bihlmeyer NA, Brody JA, Smith AV, Warren HR, Lin H, Isaacs A, Liu CT, Marten J, Radmanesh F, Hall LM, Grarup N, Mei H, Müller-Nurasyid M, Huffman JE, Verweij N, Guo X, Yao J, Li-Gao R, van den Berg M, Weiss S, Prins BP, van Setten J, Haessler J, Lyytikäinen LP, Li M, Alonso A, Soliman EZ, Bis JC, Austin T, Chen YI, Psaty BM, Harrris TB, Launer LJ, Padmanabhan S, Dominiczak A, Huang PL, Xie Z, Ellinor PT, Kors JA, Campbell A, Murray AD, Nelson CP, Tobin MD, Bork-Jensen J, Hansen T, Pedersen O, Linneberg A, Sinner MF, Peters A, Waldenberger M, Meitinger T, Perz S, Kolcic I, Rudan I, de Boer RA, van der Meer P, Lin HJ, Taylor KD, de Mutsert R, Trompet S, Jukema JW, Maan AC, Stricker BHC, Rivadeneira F, Uitterlinden A, Völker U, Homuth G, Völzke H, Felix SB, Mangino M, Spector TD, Bots ML, Perez M, Raitakari OT, Kähönen M, Mononen N, Gudnason V, Munroe PB, Lubitz SA, van Duijn CM, Newton-Cheh CH, Hayward C, Rosand J, Samani NJ, Kanters JK, Wilson JG

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PMID

Circ Genom Precis Med
11(1)
e001758 ;, 2018
PMID

Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Le

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PMID

Nat Commun
9(1)
260 ;, 2018
PMID

Saviauk T, Kiiski JP, Nieminen MK, Tamminen NN, Roine AN, Kumpulainen PS, Hokkinen LJ, Karjalainen MT, Vuento RE, Aittoniemi JJ, Lehtimäki TJ, Oksala NK
Electronic Nose in the Detection of Wound Infection Bacteria from Bacterial Cultures: A Proof-of-Principle Study.
Eur Surg Res ;59(1-2)1-11, 2018
PMID

Törnroos M, Elovainio M, Hintsa T, Hintsanen M, Pulkki-Råback L, Jokela M, Lehtimäki T, Raitakari OT, Keltikangas-Järvinen L
Personality traits and perceptions of organisational justice.
Int J Psychol ;2018
PMID

Buscot MJ, Thomson RJ, Juonala M, Sabin MA, Burgner DP, Lehtimäki T, Hutri-Kähönen N, Viikari JSA, Jokinen E, Tossavainen P, Laitinen T, Raitakari OT, Magnussen CG
BMI Trajectories Associated With Resolution of Elevated Youth BMI and Incident Adult Obesity.
Pediatrics ;2018
PMID

2017

Mozaffarian D, Dashti HS, Wojczynski MK, Chu AY, Nettleton JA, Männistö S, Kristiansson K, Reedik M, Lahti J, Houston DK, Cornelis MC, van Rooij FJA, Dimitriou M, Kanoni S, Mikkilä V, Steffen LM, de Oliveira Otto MC, Qi L, Psaty B, Djousse L, Rotter JI, Harald K, Perola M, Rissanen H, Jula A, Krista F, Mihailov E, Feitosa MF, Ngwa JS, Xue L, Jacques PF, Perälä MM, Palotie A, Liu Y, Nalls NA, Ferrucci L, Hernandez D, Manichaikul A, Tsai MY, Kiefte-de Jong JC, Hofman A, Uitterlinden AG, Rallidis L, Ridker PM, Rose LM, Buring JE, Lehtimäki T, Kähönen M, Viikari J, Lemaitre R, Salomaa V, Knekt P, Metspalu A, Borecki IB, Cupples LA, Eriksson JG, Kritchevsky SB, Bandinelli S, Siscovick D, Franco OH, Deloukas P, Dedoussis G, Chasman DI, Raitakari O, Tanaka T
Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts.
PLoS One ;12(12)e0186456, 2017
PMID

Salo PP, Havulinna AS, Tukiainen T, Raitakari O, Lehtimäki T, Kähönen M, Kettunen J, Männikkö M, Eriksson JG, Jula A, Blankenberg S, Zeller T, Salomaa V, Kristiansson K, Perola M
Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population.
Circ Cardiovasc Genet ;2017
PMID

Amin V, Böckerman P, Viinikainen J, Smart MC, Bao Y, Kumari M, Pitkänen N, Lehtimäki T, Raitakari O, Pehkonen J
Gene-environment interactions between education and body mass: Evidence from the UK and Finland.
Soc Sci Med ;2017
PMID

Wesołowska K, Elovainio M, Hintsa T, Jokela M, Pulkki-Råback L, Pitkänen N, Lipsanen J, Tukiainen J, Lyytikäinen LP, Lehtimäki T, Juonala M, Raitakari O, Keltikangas-Järvinen L
Fasting Glucose and the Risk of Depressive Symptoms: Instrumental-Variable Regression in the Cardiovascular Risk in Young Finns Study.
Int J Behav Med ;24(6)901-907, 2017
PMID

Maddock J, Zhou A, Cavadino A, Kuźma E, Bao Y, Smart MC, Saum KU, Schöttker B, Engmann J, Kjærgaard M, Karhunen V, Zhan Y, Lehtimäki T, Rovio SP, Byberg L, Lahti J, Marques-Vidal P, Sen A, Perna L, Schirmer H, Singh-Manoux A, Auvinen J, Hutri-Kähönen N, Kähönen M, Kilander L, Räikkönen K, Melhus H, Ingelsson E, Guessous I, Petrovic KE, Schmidt H, Schmidt R, Vollenweider P, Lind L, Eriksson JG, Michaëlsson K, Raitakari OT, Hägg S, Pedersen NL, Herzig KH, Järvelin MR, Veijola J, Kivimaki M, Jorde R, Brenner H, Kumari M, Power C, Llewellyn DJ, Hyppönen E
Vitamin D and cognitive function: A Mendelian randomisation study.
Sci Rep ;7(1)13230, 2017
PMID

Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ, Shen X, Gandin I, McDaid AF, Hansen TF, Gordon SD, Giulianini F, Boutin TS, Abdellaoui A, Zhao W, Medina-Gomez C, Bartz TM, Trompet S, Lange LA, Raffield L, van der Spek A, Galesloot TE, Proitsi P, Yanek LR, Bielak LF, Payton A, Murgia F, Concas MP, Biino G, Tajuddin SM, Seppälä I, Amin N, Boerwinkle E, Børglum AD, Campbell A, Demerath EW, Demuth I, Faul JD, Ford I, Gialluisi A, Gögele M, Graff M, Hingorani A, Hottenga JJ, Hougaard DM, Hurme MA, Ikram MA, Jylhä M, Kuh D, Ligthart L, Lill CM, Lindenberger U, Lumley T, Mägi R, Marques-Vidal P, Medland SE, Milani L, Nagy R, Ollier WER, Peyser PA, Pramstaller PP, Ridker PM, Rivadeneira F, Ruggiero D, Saba Y, Schmidt R, Schmidt H, Slagboom PE, Smith BH, Smith JA, Sotoodehnia N, Steinhagen-Thiessen E, van Rooij FJA, Verbeek AL, Vermeulen SH, Vollenweider P, Wang Y, Werge T, Whitfield JB, Zonder

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PMID

Nat Commun
8(1)
910 ;, 2017
PMID

Kollerits B, Lamina C, Huth C, Marques-Vidal P, Kiechl S, Seppälä I, Cooper J, Hunt SC, Meisinger C, Herder C, Kedenko L, Willeit J, Thorand B, Dähnhardt D, Stöckl D, Willeit K, Roden M, Rathmann W, Paulweber B, Peters A, Kähönen M, Lehtimäki T, Raitakari OT, Humphries SE, Vollenweider P, Dieplinger H, Kronenberg F
Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals.
Diabetes Care ;40(10)1386-1393, 2017
PMID

Laaksonen J, Taipale T, Seppälä I, Raitoharju E, Mononen N, Lyytikäinen LP, Waldenberger M, Illig T, Hutri-Kähönen N, Rönnemaa T, Juonala M, Viikari J, Kähönen M, Raitakari O, Lehtimäki T
Blood pathway analyses reveal differences between prediabetic subjects with or without dyslipidaemia. The Cardiovascular Risk in Young Finns Study.
Diabetes Metab Res Rev ;2017
PMID

Puolakka E, Pahkala K, Laitinen TT, Magnussen CG, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Tossavainen P, Jokinen E, Sabin MA, Laitinen T, Elovainio M, Pulkki-Råback L, Viikari JSA, Raitakari OT, Juonala M
Childhood Socioeconomic Status and Arterial Stiffness in Adulthood: The Cardiovascular Risk in Young Finns Study.
Hypertension ;70(4)729-735, 2017
PMID

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, McDaid AF, Porteous D, Winkler TW, Salvi E, Shrine N, Liu X, Ang WQ, Zhang W, Feitosa MF, Venturini C, van der Most PJ, Rosengren A, Wood AR, Beaumont RN, Jones SE, Ruth KS, Yaghootkar H, Tyrrell J, Havulinna AS, Boers H, Mägi R, Kriebel J, Müller-Nurasyid M, Perola M, Nieminen M, Lokki ML, Kähönen M, Viikari JS, Geller F, Lahti J, Palotie A, Koponen P, Lundqvist A, Rissanen H, Bottinger EP, Afaq S, Wojczynski MK, Lenzini P, Nolte IM, Sparsø T, Schupf N, Christensen K, Perls TT, Newman AB, Werge T, Snieder H, Spector TD, Chambers JC, Koskinen S, Melbye M, Raitakari OT, Lehtimäki T, Tobin MD, Wain LV, Sinisalo J, Peters A, Meitinger T, Martin NG, Wray NR, Montgomery GW, Medland SE, Swertz MA, Vartiainen E, Borodulin K, Männistö S, Murray A, Bochud M, Jacquemont S, Rivadeneira F, Hansen TF, Oldehinkel AJ, Mangino M, Province MA, Deloukas P, Koo

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PMID

Nat Commun
8(1)
744 ;, 2017
PMID

Sulkava M, Raitoharju E, Mennander A, Levula M, Seppälä I, Lyytikäinen LP, Järvinen O, Illig T, Klopp N, Mononen N, Laaksonen R, Kähönen M, Oksala N, Lehtimäki T
Differentially expressed genes and canonical pathways in the ascending thoracic aortic aneurysm - The Tampere Vascular Study.
Sci Rep ;7(1)12127, 2017
PMID

Weng LC, Lunetta KL, Müller-Nurasyid M, Smith AV, Thériault S, Weeke PE, Barnard J, Bis JC, Lyytikäinen LP, Kleber ME, Martinsson A, Lin HJ, Rienstra M, Trompet S, Krijthe BP, Dörr M, Klarin D, Chasman DI, Sinner MF, Waldenberger M, Launer LJ, Harris TB, Soliman EZ, Alonso A, Paré G, Teixeira PL, Denny JC, Shoemaker MB, Van Wagoner DR, Smith JD, Psaty BM, Sotoodehnia N, Taylor KD, Kähönen M, Nikus K, Delgado GE, Melander O, Engström G, Yao J, Guo X, Christophersen IE, Ellinor PT, Geelhoed B, Verweij N, Macfarlane P, Ford I, Heeringa J, Franco OH, Uitterlinden AG, Völker U, Teumer A, Rose LM, Kääb S, Gudnason V, Arking DE, Conen D, Roden DM, Chung MK, Heckbert SR, Benjamin EJ, Lehtimäki T, März W, Smith JG, Rotter JI, van der Harst P, Jukema JW, Stricker BH, Felix SB, Albert CM, Lubitz SA
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium.
Sci Rep ;7(1)11303, 2017
PMID

Serlachius A, Pulkki-Råback L, Juonala M, Sabin M, Lehtimäki T, Raitakari O, Elovainio M
Does high optimism protect against the inter-generational transmission of high BMI? The Cardiovascular Risk in Young Finns Study.
J Psychosom Res ;2017
PMID

Aatola H, Koivistoinen T, Tuominen H, Juonala M, Lehtimäki T, Viikari JSA, Raitakari OT, Kähönen M, Hutri-Kähönen N
Influence of Child and Adult Elevated Blood Pressure on Adult Arterial Stiffness: The Cardiovascular Risk in Young Finns Study.
Hypertension ;70(3)531-536, 2017
PMID

Niemi RJ, Roine AN, Häkkinen MR, Kumpulainen PS, Keinänen TA, Vepsäläinen JJ, Lehtimäki T, Oksala NK, Mäenpää JU
Urinary Polyamines as Biomarkers for Ovarian Cancer.
Int J Gynecol Cancer ;27(7)1360-1366, 2017
PMID

Pehkonen J, Viinikainen J, Böckerman P, Lehtimäki T, Pitkänen N, Raitakari O
Genetic endowments, parental resources and adult health: Evidence from the Young Finns Study.
Soc Sci Med ;2017
PMID

Pälve KS, Pahkala K, Suomela E, Aatola H, Hulkkonen J, Juonala M, Lehtimäki T, Rönnemaa T, Viikari JSA, Kähönen M, Hutri-Kähönen N, Telama R, Tammelin T, Raitakari OT
Cardiorespiratory Fitness and Risk of Fatty Liver: The Young Finns Study.
Med Sci Sports Exerc ;49(9)1834-1841, 2017
PMID

Pehkonen J, Viinikainen J, Böckerman P, Lehtimäki T, Pitkänen N, Raitakari O
The challenges of GxE research: A rejoinder.
Soc Sci Med ;2017
PMID

Nath AP, Ritchie SC, Byars SG, Fearnley LG, Havulinna AS, Joensuu A, Kangas AJ, Soininen P, Wennerström A, Milani L, Metspalu A, Männistö S, Würtz P, Kettunen J, Raitoharju E, Kähönen M, Juonala M, Palotie A, Ala-Korpela M, Ripatti S, Lehtimäki T, Abraham G, Raitakari O, Salomaa V, Perola M, Inouye M
An interaction map of circulating metabolites, immune gene networks, and their genetic regulation.
Genome Biol ;18(1)146, 2017
PMID

Böger CA, Gorski M, McMahon GM, Xu H, Chang YC, van der Most PJ, Navis G, Nolte IM, de Borst MH, Zhang W, Lehne B, Loh M, Tan ST, Boerwinkle E, Grams ME, Sekula P, Li M, Wilmot B, Moon JG, Scheet P, Cucca F, Xiao X, Lyytikäinen LP, Delgado G, Grammer TB, Kleber ME, Sedaghat S, Rivadeneira F, Corre T, Kutalik Z, Bergmann S, Nielson CM, Srikanth P, Teumer A, Müller-Nurasyid M, Brockhaus AC, Pfeufer A, Rathmann W, Peters A, Matsumoto M, de Andrade M, Atkinson EJ, Robinson-Cohen C, de Boer IH, Hwang SJ, Heid IM, Gögele M, Concas MP, Tanaka T, Bandinelli S, Nalls MA, Singleton A, Tajuddin SM, Adeyemo A, Zhou J, Doumatey A, McWeeney S, Murabito J, Franceschini N, Flessner M, Shlipak M, Wilson JG, Chen G, Rotimi CN, Zonderman AB, Evans MK, Ferrucci L, Devuyst O, Pirastu M, Shuldiner A, Hicks AA, Pramstaller PP, Kestenbaum B, Kardia SLR, Turner ST, Study LC, Briske TE, Gieger C, Strauch K, Meisinger C, Meitinger T, Völker U, Nauck M, Völzke H, Vollenweider

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PMID

J Am Soc Nephrol
28(8)
2311-2321 ;, 2017
PMID

Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz

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PMID



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PMID

2017

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PMID

Böckerman P, Viinikainen J, Pulkki-Råback L, Hakulinen C, Pitkänen N, Lehtimäki T, Pehkonen J, Raitakari OT
Does higher education protect against obesity? Evidence using Mendelian randomization.
Prev Med ;2017
PMID

Romania P, Cifaldi L, Pignoloni B, Starc N, D'Alicandro V, Melaiu O, Li Pira G, Giorda E, Carrozzo R, Bergvall M, Bergström T, Alfredsson L, Olsson T, Kockum I, Seppälä I, Lehtimäki T, Hurme MA, Hengel H, Santoni A, Cerboni C, Locatelli F, D'Amato M, Fruci D
Identification of a Genetic Variation in ERAP1 Aminopeptidase that Prevents Human Cytomegalovirus miR-UL112-5p-Mediated Immunoevasion.
Cell Rep ;20(4)846-853, 2017
PMID

Rinne P, Rami M, Nuutinen S, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki T, Weber C, Steffens S
Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.
Circulation ;136(1)83-97, 2017
PMID

Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O'Reilly PF, Cabrera CP, Warren HR, Rose LM, Verwoert GC, Hottenga JJ, Strawbridge RJ, Esko T, Arking DE, Hwang SJ, Guo X, Kutalik Z, Trompet S, Shrine N, Teumer A, Ried JS, Bis JC, Smith AV, Amin N, Nolte IM, Lyytikäinen LP, Mahajan A, Wareham NJ, Hofer E, Joshi PK, Kristiansson K, Traglia M, Havulinna AS, Goel A, Nalls MA, Sõber S, Vuckovic D, Luan J, Del Greco M F, Ayers KL, Marrugat J, Ruggiero D, Lopez LM, Niiranen T, Enroth S, Jackson AU, Nelson CP, Huffman JE, Zhang W, Marten J, Gandin I, Harris SE, Zemunik T, Lu Y, Evangelou E, Shah N, de Borst MH, Mangino M, Prins BP, Campbell A, Li-Gao R, Chauhan G, Oldmeadow C, Abecasis G, Abedi M, Barbieri CM, Barnes MR, Batini C, Beilby J, Blake T, Boehnke M, Bottinger EP, Braund PS, Brown M, Brumat M, Campbell H, Chambers JC, Cocca M, Collins F, Connell J, Cordell HJ, Damman JJ, Davies G, de Geus EJ, de Mutsert R, Deelen J, Demirkale

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PMID

Hypertension
2017
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PMID

Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, Flannick J, Fuchsberger C, Gamazon ER, Gaulton KJ, Im HK, Teslovich TM, Blackwell TW, Bork-Jensen J, Burtt NP, Chen Y, Green T, Hartl C, Kang HM, Kumar A, Ladenvall C, Ma C, Moutsianas L, Pearson RD, Perry JRB, Rayner NW, Robertson NR, Scott LJ, van de Bunt M, Eriksson JG, Jula A, Koskinen S, Lehtimäki T, Palotie A, Raitakari OT, Jacobs SBR, Wessel J, Chu AY, Scott RA, Goodarzi MO, Blancher C, Buck G, Buck D, Chines PS, Gabriel S, Gjesing AP, Groves CJ, Hollensted M, Huyghe JR, Jackson AU, Jun G, Justesen JM, Mangino M, Murphy J, Neville M, Onofrio R, Small KS, Stringham HM, Trakalo J, Banks E, Carey J, Carneiro MO, DePristo M, Farjoun Y, Fennell T, Goldstein JI, Grant G, Hrabé de Angelis M, Maguire J, Neale BM, Poplin R, Purcell S, Schwarzmayr T, Shakir K, Smith JD, Strom TM, Wieland T, Lindstr

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PMID



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PMID

66(7)
2019-2032
, 2017 ;
PMID

Auvinen A, Rannikko A, Taari K, Kujala P, Mirtti T, Kenttämies A, Rinta-Kiikka I, Lehtimäki T, Oksala N, Pettersson K, Tammela TL
A randomized trial of early detection of clinically significant prostate cancer (ProScreen): study design and rationale.
Eur J Epidemiol ;32(6)521-527, 2017
PMID

Seyednasrollah F, Mäkelä J, Pitkänen N, Juonala M, Hutri-Kähönen N, Lehtimäki T, Viikari J, Kelly T, Li C, Bazzano L, Elo LL, Raitakari OT
Prediction of Adulthood Obesity Using Genetic and Childhood Clinical Risk Factors in the Cardiovascular Risk in Young Finns Study.
Circ Cardiovasc Genet ;2017
PMID

Buscot MJ, Wotherspoon SS, Magnussen CG, Juonala M, Sabin MA, Burgner DP, Lehtimäki T, Viikari JSA, Hutri-Kähönen N, Raitakari OT, Thomson RJ
Bayesian hierarchical piecewise regression models: a tool to detect trajectory divergence between groups in long-term observational studies.
BMC Med Res Methodol ;17(1)86, 2017
PMID

van den Berg ME, Warren HR, Cabrera CP, Verweij N, Mifsud B, Haessler J, Bihlmeyer NA, Fu YP, Weiss S, Lin HJ, Grarup N, Li-Gao R, Pistis G, Shah N, Brody JA, Müller-Nurasyid M, Lin H, Mei H, Smith AV, Lyytikäinen LP, Hall LM, van Setten J, Trompet S, Prins BP, Isaacs A, Radmanesh F, Marten J, Entwistle A, Kors JA, Silva CT, Alonso A, Bis JC, de Boer R, de Haan HG, de Mutsert R, Dedoussis G, Dominiczak AF, Doney ASF, Ellinor PT, Eppinga RN, Felix SB, Guo X, Hagemeijer Y, Hansen T, Harris TB, Heckbert SR, Huang PL, Hwang SJ, Kähönen M, Kanters JK, Kolcic I, Launer LJ, Li M, Yao J, Linneberg A, Liu S, Macfarlane PW, Mangino M, Morris AD, Mulas A, Murray AD, Nelson CP, Orrú M, Padmanabhan S, Peters A, Porteous DJ, Poulter N, Psaty BM, Qi L, Raitakari OT, Rivadeneira F, Roselli C, Rudan I, Sattar N, Sever P, Sinner MF, Soliman EZ, Spector TD, Stanton AV, Stirrups KE, Taylor KD, Tobin MD, Uitterlinden A, Vaartjes I, Hoes AW, van der Meer P, Völker

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PMID

Hum Mol Genet
26(12)
2346-2363 ;, 2017
PMID

Pulkki-Råback L, Elovainio M, Hakulinen C, Lipsanen J, Kubzansky LD, Hintsanen M, Savelieva K, Serlachius A, Magnussen CG, Sabin MA, Burgner DP, Lehtimäki T, Jokinen E, Rönnemaa T, Mikkilä V, Jula A, Hutri-Kähönen N, Viikari J, Keltikangas-Järvinen L, Raitakari O, Juonala M
Positive Psychosocial Factors in Childhood Predicting Lower Risk for Adult Type 2 Diabetes: The Cardiovascular Risk in Young Finns Study, 1980-2012.
Am J Prev Med ;52(6)e157-e164, 2017
PMID

Nuotio J, Pitkänen N, Magnussen CG, Buscot MJ, Venäläinen MS, Elo LL, Jokinen E, Laitinen T, Taittonen L, Hutri-Kähönen N, Lyytikäinen LP, Lehtimäki T, Viikari JS, Juonala M, Raitakari OT
Prediction of Adult Dyslipidemia Using Genetic and Childhood Clinical Risk Factors: The Cardiovascular Risk in Young Finns Study.
Circ Cardiovasc Genet ;2017
PMID

Marques FZ, Prestes PR, Byars SG, Ritchie SC, Würtz P, Patel SK, Booth SA, Rana I, Minoda Y, Berzins SP, Curl CL, Bell JR, Wai B, Srivastava PM, Kangas AJ, Soininen P, Ruohonen S, Kähönen M, Lehtimäki T, Raitoharju E, Havulinna A, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, McGlynn M, Kelly J, Wlodek ME, Lewandowski PA, Delbridge LM, Burrell LM, Inouye M, Harrap SB, Charchar FJ
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure.
J Am Heart Assoc ;2017
PMID

Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz

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PMID



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PMID

2017

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PMID

Rovio SP, Pahkala K, Nevalainen J, Juonala M, Salo P, Kähönen M, Hutri-Kähönen N, Lehtimäki T, Jokinen E, Laitinen T, Taittonen L, Tossavainen P, Viikari JSA, Rinne JO, Raitakari OT
Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance: The Young Finns Study.
J Am Coll Cardiol ;69(18)2279-2289, 2017
PMID

Solismaa A, Kampman O, Lyytikäinen LP, Seppälä N, Viikki M, Mononen N, Lehtimäki T, Leinonen E
Histaminergic gene polymorphisms associated with sedation in clozapine-treated patients.
Eur Neuropsychopharmacol ;27(5)442-449, 2017
PMID

Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJG, Völker U, Großmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, Malzahn D, Smith AV, Sundström J, Minelli C, Ruggiero D, Lyytikäinen LP, Tiller D, Smith JG, Monnereau C, Di Tullio MR, Musani SK, Morrison AC, Pers TH, Morley M, Kleber ME, Aragam J, Benjamin EJ, Bis JC, Bisping E, Broeckel U, Cheng S, Deckers JW, Del Greco M F, Edelmann F, Fornage M, Franke L, Friedrich N, Harris TB, Hofer E, Hofman A, Huang J, Hughes AD, Kähönen M, Investigators K, Kruppa J, Lackner KJ, Lannfelt L, Laskowski R, Launer LJ, Leosdottir M, Lin H, Lindgren CM, Loley C, MacRae CA, Mascalzoni D, Mayet J, Medenwald D, Morris AP, Müller C, Müller-Nurasyid M, Nappo S, Nilsson PM, Nuding S, Nutile T, Peters A, Pfeufer A, Pietzner D, Pramstaller PP, Raitakari OT, Rice KM, Rivadeneira F, Rotter JI, Ruohonen ST, Sacco RL, Samdarshi TE, Schmidt H, Sharp ASP, Shields DC, Sorice R, Sotoodehn

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PMID

J Clin Invest
127(5)
1798-1812 ;, 2017
PMID

Gorski M, Most PJV, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger EP, Chen MH, Chouraki V, Ciullo M, Coresh J, Cornelis MC, Curhan GC, Adamo AP, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco OH, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock SJ, Harris TB, Helmer C, Höllerer S, Hofer E, Hofman A, Holliday EG, Homuth G, Hu FB, Huth C, Hutri-Kähönen N, Hwang SJ, Imboden M, Johansson Å, Kähönen M, König W, Kramer H, Krämer BK, Kumar A, Kutalik Z, Lambert JC, Launer LJ, Lehtimäki T, de Borst MH, Navis G, Swertz M, Liu Y, Lohman K, Loos RJF, Lu Y, Lyytikäinen LP, McEvoy MA, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel AJ, Olden M, Wjh Penninx B, Pistis G, Pramstaller PP, Probst-Hensch N, Raitakari O

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PMID

Sci Rep
2017
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PMID

Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa MF, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger EP, Chen MH, Chouraki V, Ciullo M, Coresh J, Cornelis MC, Curhan GC, d'Adamo AP, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco OH, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock SJ, Harris TB, Helmer C, Höllerer S, Hofer E, Hofman A, Holliday EG, Homuth G, Hu FB, Huth C, Hutri-Kähönen N, Hwang SJ, Imboden M, Johansson Å, Kähönen M, König W, Kramer H, Krämer BK, Kumar A, Kutalik Z, Lambert JC, Launer LJ, Lehtimäki T, de Borst M, Navis G, Swertz M, Liu Y, Lohman K, Loos RJF, Lu Y, Lyytikäinen LP, McEvoy MA, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel AJ, Olden M, Wjh Penninx B, Pistis G, Pramstaller PP, Probst-Hensch N, Rai

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PMID

Sci Rep
2017
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PMID

Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, Ngwa JS, Ahluwalia TS, Chu AY, Heard-Costa NL, Lim E, Perez J, Eicher JD, Kutalik Z, Xue L, Mahajan A, Renström F, Wu J, Qi Q, Ahmad S, Alfred T, Amin N, Bielak LF, Bonnefond A, Bragg J, Cadby G, Chittani M, Coggeshall S, Corre T, Direk N, Eriksson J, Fischer K, Gorski M, Neergaard Harder M, Horikoshi M, Huang T, Huffman JE, Jackson AU, Justesen JM, Kanoni S, Kinnunen L, Kleber ME, Komulainen P, Kumari M, Lim U, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Marten J, Middelberg RPS, Müller-Nurasyid M, Navarro P, Pérusse L, Pervjakova N, Sarti C, Smith AV, Smith JA, Stančáková A, Strawbridge RJ, Stringham HM, Sung YJ, Tanaka T, Teumer A, Trompet S, van der Laan SW, van der Most PJ, Van Vliet-Ostaptchouk JV, Vedantam SL, Verweij N, Vink JM, Vitart V, Wu Y, Yengo L, Zhang W, Hua Zhao J, Zimmermann ME, Zubair N, Abecasis GR, Adair LS, Afaq S

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PMID



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PMID



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PMID

Nat Commun
2017
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PMID

Seppälä I, Oksala N, Jula A, Kangas AJ, Soininen P, Hutri-Kähönen N, März W, Meinitzer A, Juonala M, Kähönen M, Raitakari OT, Lehtimäki T
The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis.
Sci Rep ;7(1)1130, 2017
PMID

Elovainio M, Pulkki-Råback L, Hakulinen C, Lehtimäki T, Jokinen E, Rönnemaa T, Mikkilä V, Tossavainen P, Jula A, Hutri-Kähönen N, Viikari J, Keltikangas-Järvinen L, Raitakari O, Juonala M
Psychosocial environment in childhood and body mass index growth over 32years.
Prev Med ;2017
PMID

Serlachius A, Elovainio M, Juonala M, Shea S, Sabin M, Lehtimäki T, Raitakari O, Keltikangas-Järvinen L, Pulkki-Råback L
The Association Between Social Support, Body Mass Index and Increased Risk of Prediabetes: the Cardiovascular Risk in Young Finns Study.
Int J Behav Med ;24(2)161-170, 2017
PMID

Vistbakka J, Elovaara I, Lehtimäki T, Hagman S
Circulating microRNAs as biomarkers in progressive multiple sclerosis.
Mult Scler ;23(3)403-412, 2017
PMID

Nevalainen T, Kananen L, Marttila S, Jylhävä J, Mononen N, Kähönen M, Raitakari OT, Hervonen A, Jylhä M, Lehtimäki T, Hurme M
Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals.
Clin Epigenetics ;2017
PMID

Böckerman P, Viinikainen J, Vainiomäki J, Hintsanen M, Pitkänen N, Lehtimäki T, Pehkonen J, Rovio S, Raitakari O
Stature and long-term labor market outcomes: Evidence using Mendelian randomization.
Econ Hum Biol ;2017
PMID

Kaikkonen JE, Würtz P, Suomela E, Lehtovirta M, Kangas AJ, Jula A, Mikkilä V, Viikari JS, Juonala M, Rönnemaa T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Soininen P, Ala-Korpela M, Raitakari OT
Metabolic profiling of fatty liver in young and middle-aged adults: Cross-sectional and prospective analyses of the Young Finns Study.
Hepatology ;65(2)491-500, 2017
PMID

Saarikoski LA, Juonala M, Huupponen R, Viikari JS, Lehtimäki T, Jokinen E, Hutri-Kähönen N, Taittonen L, Laitinen T, Raitakari OT
Low serum adiponectin levels in childhood and adolescence predict increased intima-media thickness in adulthood. The Cardiovascular Risk in Young Finns Study.
Ann Med ;49(1)42-50, 2017
PMID

Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, Kähönen M, Lyytikäinen LP, Raitoharju E, Seppälä I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT
Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors.
Am J Hum Genet ;100(1)40-50, 2017
PMID

Sulkava M, Raitoharju E, Levula M, Seppälä I, Lyytikäinen LP, Mennander A, Järvinen O, Zeitlin R, Salenius JP, Illig T, Klopp N, Mononen N, Laaksonen R, Kähönen M, Oksala N, Lehtimäki T
Differentially expressed genes and canonical pathway expression in human atherosclerotic plaques - Tampere Vascular Study.
Sci Rep ;2017
PMID

2016

Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura Lepe M, Akira S, Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J, Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Mbarek H, Milaneschi Y, Moayyeri A, Mukamal K, Nelson C, Nettleton J, Partinen E, Rawal R, Robino A, Rose L, Sala C, Satoh T, Schmidt R, Schraut K, Scott R, Smith AV, Starr JM, Teumer A, Trompet S, Uitterlinden AG, Venturini C, Vergnaud AC, Verweij N, Vitart V, Vuckovic D, Wedenoja J, Yengo L, Yu B, Zhang W, Zhao JH, Boomsma DI, Chambers J, Chasman DI, Daniela T, de Geus E, Deary I, Eriksson JG, Esko T, Eulenburg V, Franco OH, Froguel P, Gieger C, Grabe HJ, Gudnason V, Gyllensten U, Harris TB, Hartikainen AL, Heath AC, Hocking L, Hofman A, Huth C, Jarvelin MR, Jukema JW, Kaprio J, Kooner JS, Kutalik Z,

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PMID

Proc Natl Acad Sci U S A
113(50)
14372-14377 ;, 2016
PMID

Koskinen S, Kampman O, Solismaa A, Lyytikäinen LP, Seppälä N, Viikki M, Hämäläinen M, Moilanen E, Mononen N, Lehtimäki T, Leinonen E
INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine.
Pharmacogenomics ;17(18)1987-1997, 2016
PMID

Böckerman P, Bryson A, Viinikainen J, Viikari J, Lehtimäki T, Vuori E, Keltikangas-Järvinen L, Raitakari O, Pehkonen J
The serum copper/zinc ratio in childhood and educational attainment: a population-based study.
J Public Health (Oxf) ;38(4)696-703, 2016
PMID

Wang Q, Würtz P, Auro K, Mäkinen VP, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin MR, Raitakari OT, Kettunen J, Lawlor DA, Ala-Korpela M
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence.
BMC Med ;14(1)205, 2016
PMID

Raitoharju E, Seppälä I, Lyytikäinen LP, Viikari J, Ala-Korpela M, Soininen P, Kangas AJ, Waldenberger M, Klopp N, Illig T, Leiviskä J, Loo BM, Oksala N, Kähönen M, Hutri-Kähönen N, Laaksonen R, Raitakari O, Lehtimäki T
Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism-The Young Finns Study.
Sci Rep ;2016
PMID

von Essen M, Rahikainen R, Oksala N, Raitoharju E, Seppälä I, Mennander A, Sioris T, Kholová I, Klopp N, Illig T, Karhunen PJ, Kähönen M, Lehtimäki T, Hytönen VP
Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study.
Atherosclerosis ;2016
PMID

Hartiala O, Kajander S, Knuuti J, Ukkonen H, Saraste A, Rinta-Kiikka I, Kainulainen S, Kähönen M, Hutri-Kähönen N, Laitinen T, Lehtimäki T, Viikari JS, Hartiala J, Juonala M, Raitakari OT, Magnussen CG
Life-course risk factor levels and coronary artery calcification. The Cardiovascular Risk in Young Finns Study.
Int J Cardiol ;2016
PMID

Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stančáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D'Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N

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PMID



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PMID

Nat Commun
2016
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PMID

Lemmelä S, Solovieva S, Shiri R, Benner C, Heliövaara M, Kettunen J, Anttila V, Ripatti S, Perola M, Seppälä I, Juonala M, Kähönen M, Salomaa V, Viikari J, Raitakari OT, Lehtimäki T, Palotie A, Viikari-Juntura E, Husgafvel-Pursiainen K
Genome-Wide Meta-Analysis of Sciatica in Finnish Population.
PLoS One ;11(10)e0163877, 2016
PMID

Wang Q, Würtz P, Auro K, Morin-Papunen L, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Joensuu A, Havulinna AS, Aalto K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Jalkanen S, Järvelin MR, Perola M, Raitakari OT, Lawlor DA, Kettunen J, Ala-Korpela M
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence.
Int J Epidemiol ;45(5)1445-1457, 2016
PMID

Würtz P, Wang Q, Niironen M, Tynkkynen T, Tiainen M, Drenos F, Kangas AJ, Soininen P, Skilton MR, Heikkilä K, Pouta A, Kähönen M, Lehtimäki T, Rose RJ, Kajantie E, Perola M, Kaprio J, Eriksson JG, Raitakari OT, Lawlor DA, Davey Smith G, Järvelin MR, Ala-Korpela M, Auro K
Metabolic signatures of birthweight in 18 288 adolescents and adults.
Int J Epidemiol ;45(5)1539-1550, 2016
PMID

Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC, Kanoni S, Kleber ME, Lau KW, Lu Y, Lyytikäinen LP, Nelson CP, Nikpay M, Qu L, Salfati E, Scholz M, Tukiainen T, Willenborg C, Won HH, Zeng L, Zhang W, Anand SS, Beutner F, Bottinger EP, Clarke R, Dedoussis G, Do R, Esko T, Eskola M, Farrall M, Gauguier D, Giedraitis V, Granger CB, Hall AS, Hamsten A, Hazen SL, Huang J, Kähönen M, Kyriakou T, Laaksonen R, Lind L, Lindgren C, Magnusson PK, Marouli E, Mihailov E, Morris AP, Nikus K, Pedersen N, Rallidis L, Salomaa V, Shah SH, Stewart AF, Thompson JR, Zalloua PA, Chambers JC, Collins R, Ingelsson E, Iribarren C, Karhunen PJ, Kooner JS, Lehtimäki T, Loos RJ, März W, McPherson R, Metspalu A, Reilly MP, Ripatti S, Sanghera DK, Thiery J, Watkins H, Deloukas P, Kathiresan S, Samani NJ, Schunkert H, Erdmann J, König IR
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Me
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PMID

2016

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PMID

Würtz P, Cook S, Wang Q, Tiainen M, Tynkkynen T, Kangas AJ, Soininen P, Laitinen J, Viikari J, Kähönen M, Lehtimäki T, Perola M, Blankenberg S, Zeller T, Männistö S, Salomaa V, Järvelin MR, Raitakari OT, Ala-Korpela M, Leon DA
Metabolic profiling of alcohol consumption in 9778 young adults.
Int J Epidemiol ;45(5)1493-1506, 2016
PMID

Suomela E, Oikonen M, Pitkänen N, Ahola-Olli A, Virtanen J, Parkkola R, Jokinen E, Laitinen T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Taittonen L, Tossavainen P, Jula A, Loo BM, Mikkilä V, Telama R, Viikari JSA, Juonala M, Raitakari OT
Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study.
J Hepatol ;65(4)784-790, 2016
PMID

van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I, Eijgelsheim M, Sotoodehnia N, Hayward C, Sorice R, Meirelles O, Lyytikäinen LP, Polašek O, Tanaka T, Arking DE, Ulivi S, Trompet S, Müller-Nurasyid M, Smith AV, Dörr M, Kerr KF, Magnani JW, Del Greco M F, Zhang W, Nolte IM, Silva CT, Padmanabhan S, Tragante V, Esko T, Abecasis GR, Adriaens ME, Andersen K, Barnett P, Bis JC, Bodmer R, Buckley BM, Campbell H, Cannon MV, Chakravarti A, Chen LY, Delitala A, Devereux RB, Doevendans PA, Dominiczak AF, Ferrucci L, Ford I, Gieger C, Harris TB, Haugen E, Heinig M, Hernandez DG, Hillege HL, Hirschhorn JN, Hofman A, Hubner N, Hwang SJ, Iorio A, Kähönen M, Kellis M, Kolcic I, Kooner IK, Kooner JS, Kors JA, Lakatta EG, Lage K, Launer LJ, Levy D, Lundby A, Macfarlane PW, May D, Meitinger T, Metspalu A, Nappo S, Naitza S, Neph S, Nord AS, Nutile T, Okin PM, Olsen JV, Oostra BA, Penninger JM, Pennacchio LA, Pers

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PMID

J Am Coll Cardiol
68(13)
1435-14 ;
PMID



;
PMID

Serlachius A, Elovainio M, Juonala M, Shea S, Sabin M, Lehtimäki T, Raitakari O, Keltikangas-Järvinen L, Pulkki-Råback L
High perceived social support protects against the intergenerational transmission of obesity: The Cardiovascular Risk in Young Finns Study.
Prev Med ;2016
PMID

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJA, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG
Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.
Am J Hum Genet ;99(3)785, 2016
PMID

Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJ, Gibbs RA, Metcalf G, Muzny D, Veeraraghavan N, Walter K, Chen L, Yanek L, Becker LC, Peloso GM, Wakabayashi A, Kals M, Metspalu A, Esko T, Fox K, Wallace R, Franceschini N, Matijevic N, Rice KM, Bartz TM, Lyytikäinen LP, Kähönen M, Lehtimäki T, Raitakari OT, Li-Gao R, Mook-Kanamori DO, Lettre G, van Duijn CM, Franco OH, Rich SS, Rivadeneira F, Hofman A, Uitterlinden AG, Wilson JG, Psaty BM, Soranzo N, Dehghan A, Boerwinkle E, Zhang X, Johnson AD, O'Donnell CJ, Johnsen JM, Reiner AP, Ganesh SK, Sankaran VG
Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.
Am J Hum Genet ;99(2)481-8, 2016
PMID

Pitkänen N, Juonala M, Rönnemaa T, Sabin MA, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT
Role of Conventional Childhood Risk Factors Versus Genetic Risk in the Development of Type 2 Diabetes and Impaired Fasting Glucose in Adulthood: The Cardiovascular Risk in Young Finns Study.
Diabetes Care ;39(8)1393-9, 2016
PMID

Tajuddin SM, Schick UM, Eicher JD, Chami N, Giri A, Brody JA, Hill WD, Kacprowski T, Li J, Lyytikäinen LP, Manichaikul A, Mihailov E, O'Donoghue ML, Pankratz N, Pazoki R, Polfus LM, Smith AV, Schurmann C, Vacchi-Suzzi C, Waterworth DM, Evangelou E, Yanek LR, Burt A, Chen MH, van Rooij FJ, Floyd JS, Greinacher A, Harris TB, Highland HM, Lange LA, Liu Y, Mägi R, Nalls MA, Mathias RA, Nickerson DA, Nikus K, Starr JM, Tardif JC, Tzoulaki I, Velez Edwards DR, Wallentin L, Bartz TM, Becker LC, Denny JC, Raffield LM, Rioux JD, Friedrich N, Fornage M, Gao H, Hirschhorn JN, Liewald DC, Rich SS, Uitterlinden A, Bastarache L, Becker DM, Boerwinkle E, de Denus S, Bottinger EP, Hayward C, Hofman A, Homuth G, Lange E, Launer LJ, Lehtimäki T, Lu Y, Metspalu A, O'Donnell CJ, Quarells RC, Richard M, Torstenson ES, Taylor KD, Vergnaud AC, Zonderman AB, Crosslin DR, Deary IJ, Dörr M, Elliott P, Evans MK, Gudnason V, Kähönen M, Psaty BM, Rotter JI, Slater AJ, Dehgha

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PMID

Am J Hum Genet
99(1)
22-39 ;, 2016
PMID

Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L, Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N, Yanek LR, Manichaikul A, Pazoki R, Mihailov E, Hill WD, Raffield LM, Burt A, Bartz TM, Becker DM, Becker LC, Boerwinkle E, Bork-Jensen J, Bottinger EP, O'Donoghue ML, Crosslin DR, de Denus S, Dubé MP, Elliott P, Engström G, Evans MK, Floyd JS, Fornage M, Gao H, Greinacher A, Gudnason V, Hansen T, Harris TB, Hayward C, Hernesniemi J, Highland HM, Hirschhorn JN, Hofman A, Irvin MR, Kähönen M, Lange E, Launer LJ, Lehtimäki T, Li J, Liewald DC, Linneberg A, Liu Y, Lu Y, Lyytikäinen LP, Mägi R, Mathias RA, Melander O, Metspalu A, Mononen N, Nalls MA, Nickerson DA, Nikus K, O'Donnell CJ, Orho-Melander M, Pedersen O, Petersmann A, Polfus L, Psaty BM, Raitakari OT, Raitoharju E, Richard M, Rice KM, Rivadeneira F, Rotter JI, Schmidt F, Smith AV, Starr JM, Taylor KD, Teumer A, Thuesen BH, To

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PMID

Am J Hum Genet
99(1)
8-21 ;, 2016
PMID

Pappa I, St Pourcain B, Benke K, Cavadino A, Hakulinen C, Nivard MG, Nolte IM, Tiesler CM, Bakermans-Kranenburg MJ, Davies GE, Evans DM, Geoffroy MC, Grallert H, Groen-Blokhuis MM, Hudziak JJ, Kemp JP, Keltikangas-Järvinen L, McMahon G, Mileva-Seitz VR, Motazedi E, Power C, Raitakari OT, Ring SM, Rivadeneira F, Rodriguez A, Scheet PA, Seppälä I, Snieder H, Standl M, Thiering E, Timpson NJ, Veenstra R, Velders FP, Whitehouse AJ, Smith GD, Heinrich J, Hypponen E, Lehtimäki T, Middeldorp CM, Oldehinkel AJ, Pennell CE, Boomsma DI, Tiemeier H
A genome-wide approach to children's aggressive behavior: The EAGLE consortium.
Am J Med Genet B Neuropsychiatr Genet ;171(5)562-72, 2016
PMID

Cichonska A, Rousu J, Marttinen P, Kangas AJ, Soininen P, Lehtimäki T, Raitakari OT, Järvelin MR, Salomaa V, Ala-Korpela M, Ripatti S, Pirinen M
metaCCA: summary statistics-based multivariate meta-analysis of genome-wide association studies using canonical correlation analysis.
Bioinformatics ;32(13)1981-9, 2016
PMID

Rovio SP, Pahkala K, Nevalainen J, Juonala M, Salo P, Kähönen M, Hutri-Kähönen N, Lehtimäki T, Jokinen E, Laitinen T, Taittonen L, Tossavainen P, Viikari J, Rinne JO, Raitakari OT
Cognitive performance in young adulthood and midlife: Relations with age, sex, and education-The Cardiovascular Risk in Young Finns Study.
Neuropsychology ;30(5)532-42, 2016
PMID

Liu RS, Burgner DP, Sabin MA, Magnussen CG, Cheung M, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Jokinen E, Laitinen T, Taittonen L, Dwyer T, Viikari JS, Kivimäki M, Raitakari OT, Juonala M
Childhood Infections, Socioeconomic Status, and Adult Cardiometabolic Risk.
Pediatrics ;2016
PMID

Guclu-Geyik F, Onat A, Yuzbasıogulları AB, Coban N, Can G, Lehtimäki T, Erginel-Unaltuna N
Risk of obesity and metabolic syndrome associated with FTO gene variants discloses clinically relevant gender difference among Turks.
Mol Biol Rep ;43(6)485-94, 2016
PMID

Vähämurto L, Pahkala K, Magnussen CG, Mikkilä V, Hutri-Kähönen N, Kähönen M, Laitinen T, Taittonen L, Tossavainen P, Lehtimäki T, Jokinen E, Telama R, Rönnemaa T, Viikari J, Juonala M, Raitakari O
East-west differences and migration in Finland: Association with cardiometabolic risk markers and IMT. The Cardiovascular Risk in Young Finns Study.
Scand J Public Health ;44(4)402-10, 2016
PMID

Airaksinen J, Hakulinen C, Elovainio M, Pulkki-Råback L, Lehtimäki T, Raitakari OT, Keltikangas-Järvinen L, Jokela M
Moving on: How depressive symptoms, social support, and health behaviors predict residential mobility.
Scand J Public Health ;44(4)394-401, 2016
PMID

Airaksinen J, Hakulinen C, Pulkki-Råback L, Lehtimäki T, Raitakari OT, Keltikangas-Järvinen L, Jokela M
Neighbourhood effects in health behaviours: a test of social causation with repeat-measurement longitudinal data.
Eur J Public Health ;26(3)417-21, 2016
PMID

Aho V, Ollila HM, Kronholm E, Bondia-Pons I, Soininen P, Kangas AJ, Hilvo M, Seppälä I, Kettunen J, Oikonen M, Raitoharju E, Hyötyläinen T, Kähönen M, Viikari JS, Härmä M, Sallinen M, Olkkonen VM, Alenius H, Jauhiainen M, Paunio T, Lehtimäki T, Salomaa V, Orešič M, Raitakari OT, Ala-Korpela M, Porkka-Heiskanen T
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses.
Sci Rep ;2016
PMID

Kettunen J, Demirkan A, Würtz P, Draisma HH, Haller T, Rawal R, Vaarhorst A, Kangas AJ, Lyytikäinen LP, Pirinen M, Pool R, Sarin AP, Soininen P, Tukiainen T, Wang Q, Tiainen M, Tynkkynen T, Amin N, Zeller T, Beekman M, Deelen J, van Dijk KW, Esko T, Hottenga JJ, van Leeuwen EM, Lehtimäki T, Mihailov E, Rose RJ, de Craen AJ, Gieger C, Kähönen M, Perola M, Blankenberg S, Savolainen MJ, Verhoeven A, Viikari J, Willemsen G, Boomsma DI, van Duijn CM, Eriksson J, Jula A, Järvelin MR, Kaprio J, Metspalu A, Raitakari O, Salomaa V, Slagboom PE, Waldenberger M, Ripatti S, Ala-Korpela M
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.
Nat Commun ;2016
PMID

Würtz P, Wang Q, Soininen P, Kangas AJ, Fatemifar G, Tynkkynen T, Tiainen M, Perola M, Tillin T, Hughes AD, Mäntyselkä P, Kähönen M, Lehtimäki T, Sattar N, Hingorani AD, Casas JP, Salomaa V, Kivimäki M, Järvelin MR, Davey Smith G, Vanhala M, Lawlor DA, Raitakari OT, Chaturvedi N, Kettunen J, Ala-Korpela M
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase.
J Am Coll Cardiol ;67(10)1200-1210, 2016
PMID

Seppälä I, Kleber ME, Bevan S, Lyytikäinen LP, Oksala N, Hernesniemi JA, Mäkelä KM, Rothwell PM, Sudlow C, Dichgans M, Mononen N, Vlachopoulou E, Sinisalo J, Delgado GE, Laaksonen R, Koskinen T, Scharnagl H, Kähönen M, Markus HS, März W, Lehtimäki T
Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke.
Sci Rep ;2016
PMID

Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BW, Jansen R, de Geus EJ, Boomsma DI, Wright FA, Sullivan PF, Nikkola E, Alvarez M, Civelek M, Lusis AJ, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Raitakari OT, Kuusisto J, Laakso M, Price AL, Pajukanta P, Pasaniuc B
Integrative approaches for large-scale transcriptome-wide association studies.
Nat Genet ;48(3)245-52, 2016
PMID

Enroth L, Raitanen J, Hervonen A, Lehtimäki T, Jylhävä J, Hurme M, Jylhä M
Cardiometabolic and Inflammatory Biomarkers as Mediators Between Educational Attainment and Functioning at the Age of 90 Years.
J Gerontol A Biol Sci Med Sci ;71(3)412-9, 2016
PMID

Ware JJ, Chen X, Vink J, Loukola A, Minica C, Pool R, Milaneschi Y, Mangino M, Menni C, Chen J, Peterson RE, Auro K, Lyytikäinen LP, Wedenoja J, Stiby AI, Hemani G, Willemsen G, Hottenga JJ, Korhonen T, Heliövaara M, Perola M, Rose RJ, Paternoster L, Timpson N, Wassenaar CA, Zhu AZ, Davey Smith G, Raitakari OT, Lehtimäki T, Kähönen M, Koskinen S, Spector T, Penninx BW, Salomaa V, Boomsma DI, Tyndale RF, Kaprio J, Munafò MR
Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2.
Sci Rep ;2016
PMID

Delcourt C, Korobelnik JF, Buitendijk GH, Foster PJ, Hammond CJ, Piermarocchi S, Peto T, Jansonius N, Mirshahi A, Hogg RE, Bretillon L, Topouzis F, Deak G, Grauslund J, Broe R, Souied EH, Creuzot-Garcher C, Sahel J, Daien V, Lehtimäki T, Hense HW, Prokofyeva E, Oexle K, Rahi JS, Cumberland PM, Schmitz-Valckenberg S, Fauser S, Bertelsen G, Hoyng C, Bergen A, Silva R, Wolf S, Lotery A, Chakravarthy U, Fletcher A, Klaver CC
Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium.
Eur J Epidemiol ;31(2)197-210, 2016
PMID

Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z, Drong AW, Esko T, Evans DM, Falchi M, Feitosa MF, Ferreira T, Hedman ÅK, Haring R, Hysi PG, Iles MM, Justice AE, Kanoni S, Lagou V, Li R, Li X, Locke A, Lu C, Mägi R, Perry JR, Pers TH, Qi Q, Sanna M, Schmidt EM, Scott WR, Shungin D, Teumer A, Vinkhuyzen AA, Walker RW, Westra HJ, Zhang M, Zhang W, Zhao JH, Zhu Z, Afzal U, Ahluwalia TS, Bakker SJ, Bellis C, Bonnefond A, Borodulin K, Buchman AS, Cederholm T, Choh AC, Choi HJ, Curran JE, de Groot LC, De Jager PL, Dhonukshe-Rutten RA, Enneman AW, Eury E, Evans DS, Forsen T, Friedrich N, Fumeron F, Garcia ME, Gärtner S, Han BG, Havulinna AS, Hayward C, Hernandez D, Hillege H, Ittermann T, Kent JW, Kolcic I, Laatikainen T, Lahti J, Mateo Leach I, Lee CG, Lee JY, Liu T, Liu Y, Lobbens S, Loh M, Lyytikäinen LP, Medina-Gomez C, Michaëlsson K, Nalls MA, Nielson CM, Oozageer L, Pascoe L, Paternoster L, Polašek O, Ripatti S, Sarzy

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PMID



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PMID



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PMID

2016

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PMID

Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morr

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PMID



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PMID

Nat Commun
2016
;
PMID

Ruohonen S, Koskenvuo JW, Wendelin-Saarenhovi M, Savontaus M, Kähönen M, Laitinen T, Lehtimäki T, Jokinen E, Viikari J, Juonala M, Taittonen L, Tossavainen P, Kallio M, Bax JJ, Raitakari O
Reference Values for Echocardiography in Middle-Aged Population: The Cardiovascular Risk in Young Finns Study.
Echocardiography ;33(2)193-206, 2016
PMID

Pyysalo MJ, Pyysalo LM, Pessi T, Karhunen PJ, Lehtimäki T, Oksala N, Öhman JE
Bacterial DNA findings in ruptured and unruptured intracranial aneurysms.
Acta Odontol Scand ;74(4)315-20, 2016
PMID

Kaikkonen JE, Kresanov P, Ahotupa M, Jula A, Mikkilä V, Viikari JS, Juonala M, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Kangas AJ, Soininen P, Ala-Korpela M, Raitakari OT
Longitudinal study of circulating oxidized LDL and HDL and fatty liver: the Cardiovascular Risk in Young Finns Study.
Free Radic Res ;50(4)396-404, 2016
PMID

Laurila PP, Soronen J, Kooijman S, Forsström S, Boon MR, Surakka I, Kaiharju E, Coomans CP, Van Den Berg SA, Autio A, Sarin AP, Kettunen J, Tikkanen E, Manninen T, Metso J, Silvennoinen R, Merikanto K, Ruuth M, Perttilä J, Mäkelä A, Isomi A, Tuomainen AM, Tikka A, Ramadan UA, Seppälä I, Lehtimäki T, Eriksson J, Havulinna A, Jula A, Karhunen PJ, Salomaa V, Perola M, Ehnholm C, Lee-Rueckert M, Van Eck M, Roivainen A, Taskinen MR, Peltonen L, Mervaala E, Jalanko A, Hohtola E, Olkkonen VM, Ripatti S, Kovanen PT, Rensen PC, Suomalainen A, Jauhiainen M
USF1 deficiency activates brown adipose tissue and improves cardiometabolic health.
Sci Transl Med ;8(323)323ra13, 2016
PMID

Buscot MJ, Magnussen CG, Juonala M, Pitkänen N, Lehtimäki T, Viikari JS, Kähönen M, Hutri-Kähönen N, Schork NJ, Raitakari OT, Thomson RJ
The Combined Effect of Common Genetic Risk Variants on Circulating Lipoproteins Is Evident in Childhood: A Longitudinal Analysis of the Cardiovascular Risk in Young Finns Study.
PLoS One ;11(1)e0146081, 2016
PMID

2015

Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, Webb TR, Zeng L, Dehghan A, Alver M, Armasu SM, Auro K, Bjonnes A, Chasman DI, Chen S, Ford I, Franceschini N, Gieger C, Grace C, Gustafsson S, Huang J, Hwang SJ, Kim YK, Kleber ME, Lau KW, Lu X, Lu Y, Lyytikäinen LP, Mihailov E, Morrison AC, Pervjakova N, Qu L, Rose LM, Salfati E, Saxena R, Scholz M, Smith AV, Tikkanen E, Uitterlinden A, Yang X, Zhang W, Zhao W, de Andrade M, de Vries PS, van Zuydam NR, Anand SS, Bertram L, Beutner F, Dedoussis G, Frossard P, Gauguier D, Goodall AH, Gottesman O, Haber M, Han BG, Huang J, Jalilzadeh S, Kessler T, König IR, Lannfelt L, Lieb W, Lind L, Lindgren CM, Lokki ML, Magnusson PK, Mallick NH, Mehra N, Meitinger T, Memon FU, Morris AP, Nieminen MS, Pedersen NL, Peters A, Rallidis LS, Rasheed A, Samuel M, Shah SH, Sinisalo J, Stirrups KE, Trompet S, Wang L, Zaman KS, Ardissino D, Boerwinkle E, Borecki IB, Botti

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PMID

Nat Genet
47(10)
1121-1130 ;, 2015
PMID

Elovainio M, Taipale T, Seppälä I, Mononen N, Raitoharju E, Jokela M, Pulkki-Råback L, Illig T, Waldenberger M, Hakulinen C, Hintsa T, Kivimäki M, Kähönen M, Keltikangas-Järvinen L, Raitakari O, Lehtimäki T
Activated immune-inflammatory pathways are associated with long-standing depressive symptoms: Evidence from gene-set enrichment analyses in the Young Finns Study.
J Psychiatr Res ;2015
PMID

Juonala M, Sabin MA, Burgner D, Cheung M, Kähönen M, Hutri-Kähönen N, Lehtimäki T, Jokinen E, Koskinen J, Tossavainen P, Laitinen T, Viikari JS, Raitakari OT, Magnussen CG
Increased Body Mass Index in Parent-Child Dyads Predicts the Offspring Risk of Meeting Bariatric Surgery Criteria.
J Clin Endocrinol Metab ;100(11)4257-63, 2015
PMID

Fretts AM, Follis JL, Nettleton JA, Lemaitre RN, Ngwa JS, Wojczynski MK, Kalafati IP, Varga TV, Frazier-Wood AC, Houston DK, Lahti J, Ericson U, van den Hooven EH, Mikkilä V, Kiefte-de Jong JC, Mozaffarian D, Rice K, Renström F, North KE, McKeown NM, Feitosa MF, Kanoni S, Smith CE, Garcia ME, Tiainen AM, Sonestedt E, Manichaikul A, van Rooij FJ, Dimitriou M, Raitakari O, Pankow JS, Djoussé L, Province MA, Hu FB, Lai CQ, Keller MF, Perälä MM, Rotter JI, Hofman A, Graff M, Kähönen M, Mukamal K, Johansson I, Ordovas JM, Liu Y, Männistö S, Uitterlinden AG, Deloukas P, Seppälä I, Psaty BM, Cupples LA, Borecki IB, Franks PW, Arnett DK, Nalls MA, Eriksson JG, Orho-Melander M, Franco OH, Lehtimäki T, Dedoussis GV, Meigs JB, Siscovick DS
Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians.
Am J Clin Nutr ;102(5)1266-78, 201
PMID



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PMID

Hartiala O, Magnussen CG, Bucci M, Kajander S, Knuuti J, Ukkonen H, Saraste A, Rinta-Kiikka I, Kainulainen S, Kähönen M, Hutri-Kähönen N, Laitinen T, Lehtimäki T, Viikari JS, Hartiala J, Juonala M, Raitakari OT
Coronary heart disease risk factors, coronary artery calcification and epicardial fat volume in the Young Finns Study.
Eur Heart J Cardiovasc Imaging ;16(11)1256-63, 2015
PMID

Ritchie SC, Würtz P, Nath AP, Abraham G, Havulinna AS, Fearnley LG, Sarin AP, Kangas AJ, Soininen P, Aalto K, Seppälä I, Raitoharju E, Salmi M, Maksimow M, Männistö S, Kähönen M, Juonala M, Ripatti S, Lehtimäki T, Jalkanen S, Perola M, Raitakari O, Salomaa V, Ala-Korpela M, Kettunen J, Inouye M
The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection.
Cell Syst ;1(4)293-301, 2015
PMID

Loukola A, Buchwald J, Gupta R, Palviainen T, Hällfors J, Tikkanen E, Korhonen T, Ollikainen M, Sarin AP, Ripatti S, Lehtimäki T, Raitakari O, Salomaa V, Rose RJ, Tyndale RF, Kaprio J
A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.
PLoS Genet ;11(9)e1005498, 2015
PMID

Burgner DP, Sabin MA, Magnussen CG, Cheung M, Kähönen M, Lehtimäki T, Hutri-Kähönen N, Jokinen E, Laitinen T, Taittonen L, Tossavainen P, Dwyer T, Viikari JS, Raitakari OT, Juonala M
Infection-Related Hospitalization in Childhood and Adult Metabolic Outcomes.
Pediatrics ;136(3)e554-62, 2015
PMID

Oksala N, Pärssinen J, Seppälä I, Klopp N, Illig T, Laaksonen R, Levula M, Raitoharju E, Kholova I, Sioris T, Kähönen M, Lehtimäki T, Hytönen VP
Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.
Atherosclerosis ;242(1)145-54, 2015
PMID

Minkkinen M, Nieminen T, Verrier RL, Leino J, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M
Prognostic capacity of a clinically indicated exercise test for cardiovascular mortality is enhanced by combined analysis of exercise capacity, heart rate recovery and T-wave alternans.
Eur J Prev Cardiol ;22(9)1162-70, 2015
PMID

Arnott C, Skilton MR, Ruohonen S, Juonala M, Viikari JS, Kähönen M, Lehtimäki T, Laitinen T, Celermajer DS, Raitakari OT
Subtle increases in heart size persist into adulthood in growth restricted babies: the Cardiovascular Risk in Young Finns Study.
Open Heart ;2(1)e000265, 2015
PMID

Juonala M, Cheung MM, Sabin MA, Burgner D, Skilton MR, Kähönen M, Hutri-Kähönen N, Lehtimäki T, Jula A, Laitinen T, Jokinen E, Taittonen L, Tossavainen P, Viikari JS, Magnussen CG, Raitakari OT
Effect of birth weight on life-course blood pressure levels among children born premature: the Cardiovascular Risk in Young Finns Study.
J Hypertens ;33(8)1542-8, 2015
PMID

Kresanov P, Vasankari T, Ahotupa M, Kaikkonen J, Hutri-Kähönen N, Juonala M, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT
Paraoxonase-1 and oxidized lipoprotein lipids. The Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;241(2)502-6, 2015
PMID

Nettleton JA, Follis JL, Ngwa JS, Smith CE, Ahmad S, Tanaka T, Wojczynski MK, Voortman T, Lemaitre RN, Kristiansson K, Nuotio ML, Houston DK, Perälä MM, Qi Q, Sonestedt E, Manichaikul A, Kanoni S, Ganna A, Mikkilä V, North KE, Siscovick DS, Harald K, Mckeown NM, Johansson I, Rissanen H, Liu Y, Lahti J, Hu FB, Bandinelli S, Rukh G, Rich S, Booij L, Dmitriou M, Ax E, Raitakari O, Mukamal K, Männistö S, Hallmans G, Jula A, Ericson U, Jacobs DR, Van Rooij FJ, Deloukas P, Sjögren P, Kähönen M, Djousse L, Perola M, Barroso I, Hofman A, Stirrups K, Viikari J, Uitterlinden AG, Kalafati IP, Franco OH, Mozaffarian D, Salomaa V, Borecki IB, Knekt P, Kritchevsky SB, Eriksson JG, Dedoussis GV, Qi L, Ferrucci L, Orho-Melander M, Zillikens MC, Ingelsson E, Lehtimäki T, Renström F, Cupples LA, Loos RJ, Franks PW
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry.
Hum Mol Genet ;24(16)4728-38, 2015
PMID

Airaksinen J, Hakulinen C, Elovainio M, Lehtimäki T, Raitakari OT, Keltikangas-Järvinen L, Jokela M
Neighborhood effects in depressive symptoms, social support, and mistrust: Longitudinal analysis with repeated measurements.
Soc Sci Med ;2015
PMID

Rinne P, Ahola-Olli A, Nuutinen S, Koskinen E, Kaipio K, Eerola K, Juonala M, Kähönen M, Lehtimäki T, Raitakari OT, Savontaus E
Deficiency in Melanocortin 1 Receptor Signaling Predisposes to Vascular Endothelial Dysfunction and Increased Arterial Stiffness in Mice and Humans.
Arterioscler Thromb Vasc Biol ;35(7)1678-86, 2015
PMID

Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo X, Chasman DI, O'Connel JR, Corre T, Nongmaithem SS, Chen Y, Mangino M, Ruggiero D, Traglia M, Farmaki AE, Kacprowski T, Bjonnes A, van der Spek A, Wu Y, Giri AK, Yanek LR, Wang L, Hofer E, Rietveld CA, McLeod O, Cornelis MC, Pattaro C, Verweij N, Baumbach C, Abdellaoui A, Warren HR, Vuckovic D, Mei H, Bouchard C, Perry JRB, Cappellani S, Mirza SS, Benton MC, Broeckel U, Medland SE, Lind PA, Malerba G, Drong A, Yengo L, Bielak LF, Zhi D, van der Most PJ, Shriner D, Mägi R, Hemani G, Karaderi T, Wang Z, Liu T, Demuth I, Zhao JH, Meng W, Lataniotis L, van der Laan SW, Bradfield JP, Wood AR, Bonnefond A, Ahluwalia TS, Hall LM, Salvi E, Yazar S, Carstensen L, de Haan HG, Abney M, Afzal U, Allison MA, Amin N, Asselbergs FW, Bakker SJL, Barr RG,

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PMID



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PMID



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PMID



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PMID

Nature
523(7561)
459-462 ;, 2015
PMID

Hernesniemi JA, Lyytikäinen LP, Oksala N, Seppälä I, Kleber ME, Mononen N, März W, Mikkelsson J, Pessi T, Louhelainen AM, Martiskainen M, Nikus K, Klopp N, Waldenberger M, Illig T, Kähönen M, Laaksonen R, Karhunen PJ, Lehtimäki T
Predicting sudden cardiac death using common genetic risk variants for coronary artery disease.
Eur Heart J ;36(26)1669-75, 2015
PMID

Turpeinen H, Seppälä I, Lyytikäinen LP, Raitoharju E, Hutri-Kähönen N, Levula M, Oksala N, Waldenberger M, Klopp N, Illig T, Mononen N, Laaksonen R, Raitakari O, Kähönen M, Lehtimäki T, Pesu M
A genome-wide expression quantitative trait loci analysis of proprotein convertase subtilisin/kexin enzymes identifies a novel regulatory gene variant for FURIN expression and blood pressure.
Hum Genet ;134(6)627-36, 2015
PMID

Hussain SM, Kähönen M, Raitakari OT, Skilton MR, Witt N, Chaturvedi N, Hutri-Kähönen N, Lehtimäki T, Vaahtoranta-Lehtonen H, Juonala M, Wijetunge S, Hughes AD, McG Thom SA, Metha A, Tapp RJ
Impact of fetal growth and preterm birth on the retinal microvasculature in mid-adulthood.
Microcirculation ;22(4)285-93, 2015
PMID

Voipio AJ, Pahkala KA, Viikari JS, Mikkilä V, Magnussen CG, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Männistö S, Loo BM, Jula A, Marniemi J, Juonala M, Raitakari OT
Determinants of serum 25(OH)D concentration in young and middle-aged adults. The Cardiovascular Risk in Young Finns Study.
Ann Med ;47(3)253-62, 2015
PMID

Gorski M, Tin A, Garnaas M, McMahon GM, Chu AY, Tayo BO, Pattaro C, Teumer A, Chasman DI, Chalmers J, Hamet P, Tremblay J, Woodward M, Aspelund T, Eiriksdottir G, Gudnason V, Harris TB, Launer LJ, Smith AV, Mitchell BD, O'Connell JR, Shuldiner AR, Coresh J, Li M, Freudenberger P, Hofer E, Schmidt H, Schmidt R, Holliday EG, Mitchell P, Wang JJ, de Boer IH, Li G, Siscovick DS, Kutalik Z, Corre T, Vollenweider P, Waeber G, Gupta J, Kanetsky PA, Hwang SJ, Olden M, Yang Q, de Andrade M, Atkinson EJ, Kardia SL, Turner ST, Stafford JM, Ding J, Liu Y, Barlassina C, Cusi D, Salvi E, Staessen JA, Ridker PM, Grallert H, Meisinger C, Müller-Nurasyid M, Krämer BK, Kramer H, Rosas SE, Nolte IM, Penninx BW, Snieder H, Fabiola Del Greco M, Franke A, Nöthlings U, Lieb W, Bakker SJ, Gansevoort RT, van der Harst P, Dehghan A, Franco OH, Hofman A, Rivadeneira F, Sedaghat S, Uitterlinden AG, Coassin S, Haun M, Kollerits B, Kronenberg F, Paulweber B, Aumann N, Endlich K, Pi

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PMID

Kidney Int
87(5)
1017-29 ;, 2015
PMID

Wang Q, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Puukka K, Ruokonen A, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Davey Smith G, Raitakari OT, Järvelin MR, Würtz P, Kettunen J, Ala-Korpela M
Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates.
Int J Epidemiol ;44(2)623-37, 2015
PMID

Kaikkonen JE, Mikkilä V, Juonala M, Keltikangas-Järvinen L, Hintsanen M, Pulkki-Råback L, Viikari JS, Kähönen M, Lehtimäki T, Telama R, Raitakari OT
Factors associated with six-year weight change in young and middle-aged adults in the Young Finns Study.
Scand J Clin Lab Invest ;75(2)133-44, 2015
PMID

Pessi T, Viiri LE, Raitoharju E, Astola N, Seppälä I, Waldenberger M, Lounatmaa K, Davies AH, Lehtimäki T, Karhunen PJ, Monaco C
Interleukin-6 and microRNA profiles induced by oral bacteria in human atheroma derived and healthy smooth muscle cells.
Springerplus ;2015
PMID

Burgner DP, Sabin MA, Magnussen CG, Cheung M, Sun C, Kähönen M, Hutri-Kähönen N, Lehtimäki T, Jokinen E, Laitinen T, Viikari JS, Raitakari OT, Juonala M
Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: the Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;239(2)496-502, 2015
PMID

Hagman S, Kolasa M, Basnyat P, Helminen M, Kähönen M, Dastidar P, Lehtimäki T, Elovaara I
Analysis of apoptosis-related genes in patients with clinically isolated syndrome and their association with conversion to multiple sclerosis.
J Neuroimmunol ;2015
PMID

Kautto M, Kampman O, Mononen N, Lehtimäki T, Haraldsson S, Koivisto PA, Leinonen E
Serotonin transporter (5-HTTLPR) and norepinephrine transporter (NET) gene polymorphisms: susceptibility and treatment response of electroconvulsive therapy in treatment resistant depression.
Neurosci Lett ;2015
PMID

Würtz P, Havulinna AS, Soininen P, Tynkkynen T, Prieto-Merino D, Tillin T, Ghorbani A, Artati A, Wang Q, Tiainen M, Kangas AJ, Kettunen J, Kaikkonen J, Mikkilä V, Jula A, Kähönen M, Lehtimäki T, Lawlor DA, Gaunt TR, Hughes AD, Sattar N, Illig T, Adamski J, Wang TJ, Perola M, Ripatti S, Vasan RS, Raitakari OT, Gerszten RE, Casas JP, Chaturvedi N, Ala-Korpela M, Salomaa V
Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts.
Circulation ;131(9)774-85, 2015
PMID

Haataja P, Anttila I, Nikus K, Eskola M, Huhtala H, Nieminen T, Jula A, Salomaa V, Reunanen A, Nieminen MS, Lehtimäki T, Sclarovsky S, Kähönen M
Prognostic implications of intraventricular conduction delays in a general population: the Health 2000 Survey.
Ann Med ;47(1)74-80, 2015
PMID

Tapp RJ, Hussain SM, Battista J, Hutri-Kähönen N, Lehtimäki T, Hughes AD, Thom SA, Metha A, Raitakari OT, Kähönen M
Impact of blood pressure on retinal microvasculature architecture across the lifespan: the Young Finns Study.
Microcirculation ;22(2)146-55, 2015
PMID

Suomela E, Oikonen M, Virtanen J, Parkkola R, Jokinen E, Laitinen T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Taittonen L, Tossavainen P, Jula A, Loo BM, Mikkilä V, Younossi Z, Viikari JS, Juonala M, Raitakari OT
Prevalence and determinants of fatty liver in normal-weight and overweight young adults. The Cardiovascular Risk in Young Finns Study.
Ann Med ;47(1)40-6, 2015
PMID

Martiskainen H, Helisalmi S, Viswanathan J, Kurki M, Hall A, Herukka SK, Sarajärvi T, Natunen T, Kurkinen KM, Huovinen J, Mäkinen P, Laitinen M, Koivisto AM, Mattila KM, Lehtimäki T, Remes AM, Leinonen V, Haapasalo A, Soininen H, Hiltunen M
Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach.
J Alzheimers Dis ;43(2)565-73, 2015
PMID

Helajärvi H, Pahkala K, Heinonen OJ, Juonala M, Oikonen M, Tammelin T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Mikkilä V, Viikari J, Raitakari OT
Television viewing and fatty liver in early midlife. The Cardiovascular Risk in Young Finns Study.
Ann Med ;47(6)519-26, 2015
PMID

Serlachius A, Pulkki-Råback L, Elovainio M, Hintsanen M, Mikkilä V, Laitinen TT, Jokela M, Rosenström T, Josefsson K, Juonala M, Lehtimäki T, Raitakari O, Keltikangas-Järvinen L
Is dispositional optimism or dispositional pessimism predictive of ideal cardiovascular health? The Young Finns Study.
Psychol Health ;30(10)1221-39, 2015
PMID

Andre K, Kampman O, Illi A, Viikki M, Setälä-Soikkeli E, Mononen N, Lehtimäki T, Haraldsson S, Koivisto PA, Leinonen E
SERT and NET polymorphisms, temperament and antidepressant response.
Nord J Psychiatry ;69(7)531-8, 2015
PMID

Sabin MA, Magnussen CG, Juonala M, Shield JP, Kähönen M, Lehtimäki T, Rönnemaa T, Koskinen J, Loo BM, Knip M, Hutri-Kähönen N, Viikari JS, Dwyer T, Raitakari OT
Insulin and BMI as predictors of adult type 2 diabetes mellitus.
Pediatrics ;135(1)e144-51, 2015
PMID

Dashti HS, Follis JL, Smith CE, Tanaka T, Cade BE, Gottlieb DJ, Hruby A, Jacques PF, Lamon-Fava S, Richardson K, Saxena R, Scheer FA, Kovanen L, Bartz TM, Perälä MM, Jonsson A, Frazier-Wood AC, Kalafati IP, Mikkilä V, Partonen T, Lemaitre RN, Lahti J, Hernandez DG, Toft U, Johnson WC, Kanoni S, Raitakari OT, Perola M, Psaty BM, Ferrucci L, Grarup N, Highland HM, Rallidis L, Kähönen M, Havulinna AS, Siscovick DS, Räikkönen K, Jørgensen T, Rotter JI, Deloukas P, Viikari JS, Mozaffarian D, Linneberg A, Seppälä I, Hansen T, Salomaa V, Gharib SA, Eriksson JG, Bandinelli S, Pedersen O, Rich SS, Dedoussis G, Lehtimäki T, Ordovás JM
Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants.
Am J Clin Nutr ;101(1)135-43, 2015
PMID

2014

Roine A, Saviauk T, Kumpulainen P, Karjalainen M, Tuokko A, Aittoniemi J, Vuento R, Lekkala J, Lehtimäki T, Tammela TL, Oksala NK
Rapid and accurate detection of urinary pathogens by mobile IMS-based electronic nose: a proof-of-principle study.
PLoS One ;9(12)e114279, 2014
PMID

Ollila HM, Kettunen J, Pietiläinen O, Aho V, Silander K, Kronholm E, Perola M, Lahti J, Räikkönen K, Widen E, Palotie A, Eriksson JG, Partonen T, Kaprio J, Salomaa V, Raitakari O, Lehtimäki T, Sallinen M, Härmä M, Porkka-Heiskanen T, Paunio T
Genome-wide association study of sleep duration in the Finnish population.
J Sleep Res ;23(6)609-618, 2014
PMID

Würtz P, Wang Q, Kangas AJ, Richmond RC, Skarp J, Tiainen M, Tynkkynen T, Soininen P, Havulinna AS, Kaakinen M, Viikari JS, Savolainen MJ, Kähönen M, Lehtimäki T, Männistö S, Blankenberg S, Zeller T, Laitinen J, Pouta A, Mäntyselkä P, Vanhala M, Elliott P, Pietiläinen KH, Ripatti S, Salomaa V, Raitakari OT, Järvelin MR, Smith GD, Ala-Korpela M
Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change.
PLoS Med ;11(12)e1001765, 2014
PMID

Ahola-Olli AV, Pitkänen N, Kettunen J, Oikonen MK, Mikkilä V, Lehtimäki T, Kähönen M, Pahkala K, Niinikoski H, Kangas AJ, Soininen P, Ala-Korpela M, Viikari JS, Rönnemaa T, Simell O, Raitakari OT
Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children.
Am J Clin Nutr ;100(6)1569-77, 2014
PMID

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renström F, Lin X, Ängquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JM, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao YT, Heppe DH, Holloway JW, Houston DK, Kanoni S, Kim YM, Laaksonen MA, Jääskeläinen T, Lee NR, Lehtimäki T, Lemaitre RN, Lu W, Luben RN, Manichaikul A, Männistö S, Marques-Vidal P, Monda KL, Ngwa JS, Perusse L, van Rooij FJ, Xiang YB, Wen W, Wojczynski MK, Zhu J, Borecki IB, Bouchard C, Cai Q, Cooper C, Dedoussis GV, Deloukas P, Ferrucci L, Forouhi NG, Hansen T, Christiansen L, Hofman A, Johansson I, Jørgensen T, Karasawa S, Khaw KT, Kim MK, Kristiansson K, Li H, Lin X, Liu Y, Lohman KK, Long J, Mikkilä V, Mozaffarian D, North K, Pedersen O, Raitakari O, Rissanen H, Tuomilehto J, van der Schouw YT, Uitterlinden AG, Zillikens MC, Franco OH, Shyong Tai E, Ou Shu X, Siscovick DS, Toft U, Verschuren WM, Vollenweider P,

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PMID

Hum Mol Genet
23(25)
6961-72 ;, 2014
PMID

Herder C, Nuotio ML, Shah S, Blankenberg S, Brunner EJ, Carstensen M, Gieger C, Grallert H, Jula A, Kähönen M, Kettunen J, Kivimäki M, Koenig W, Kristiansson K, Langenberg C, Lehtimäki T, Luotola K, Marzi C, Müller C, Peters A, Prokisch H, Raitakari O, Rathmann W, Roden M, Salmi M, Schramm K, Swerdlow D, Tabak AG, Thorand B, Wareham N, Wild PS, Zeller T, Hingorani AD, Witte DR, Kumari M, Perola M, Salomaa V
Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits.
Diabetes ;63(12)4343-59, 2014
PMID

Hjelt S, Aatola H, Kähönen M, Juonala M, Koivistoinen T, Lehtimäki T, Viikari JS, Raitakari OT, Laitinen T, Hutri-Kähönen N
Association of thyrotropin with arterial pulse wave velocity in young adults: the Cardiovascular Risk in Young Finns Study.
Scand J Clin Lab Invest ;74(8)716-21, 2014
PMID

Nuotio J, Oikonen M, Magnussen CG, Jokinen E, Laitinen T, Hutri-Kähönen N, Kähönen M, Lehtimäki T, Taittonen L, Tossavainen P, Jula A, Loo BM, Viikari JS, Raitakari OT, Juonala M
Cardiovascular risk factors in 2011 and secular trends since 2007: the Cardiovascular Risk in Young Finns Study.
Scand J Public Health ;42(7)563-71, 2014
PMID

Sandell M, Hoppu U, Mikkilä V, Mononen N, Kähönen M, Männistö S, Rönnemaa T, Viikari J, Lehtimäki T, Raitakari OT
Genetic variation in the hTAS2R38 taste receptor and food consumption among Finnish adults.
Genes Nutr ;9(6)433, 2014
PMID

Screen M, Jonson PH, Raheem O, Palmio J, Laaksonen R, Lehtimäki T, Sirito M, Krahe R, Hackman P, Udd B
Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions.
Am J Pathol ;184(8)2322-32, 2014
PMID

Auro K, Joensuu A, Fischer K, Kettunen J, Salo P, Mattsson H, Niironen M, Kaprio J, Eriksson JG, Lehtimäki T, Raitakari O, Jula A, Tiitinen A, Jauhiainen M, Soininen P, Kangas AJ, Kähönen M, Havulinna AS, Ala-Korpela M, Salomaa V, Metspalu A, Perola M
A metabolic view on menopause and ageing.
Nat Commun ;2014
PMID

Solismaa A, Kampman O, Seppälä N, Viikki M, Mäkelä KM, Mononen N, Lehtimäki T, Leinonen E
Polymorphism in alpha 2A adrenergic receptor gene is associated with sialorrhea in schizophrenia patients on clozapine treatment.
Hum Psychopharmacol ;29(4)336-41, 2014
PMID

Helajärvi H, Rosenström T, Pahkala K, Kähönen M, Lehtimäki T, Heinonen OJ, Oikonen M, Tammelin T, Viikari JS, Raitakari OT
Exploring causality between TV viewing and weight change in young and middle-aged adults. The Cardiovascular Risk in Young Finns study.
PLoS One ;9(7)e101860, 2014
PMID

Marttinen P, Pirinen M, Sarin AP, Gillberg J, Kettunen J, Surakka I, Kangas AJ, Soininen P, O'Reilly P, Kaakinen M, Kähönen M, Lehtimäki T, Ala-Korpela M, Raitakari OT, Salomaa V, Järvelin MR, Ripatti S, Kaski S
Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression.
Bioinformatics ;30(14)2026-34, 2014
PMID

Roine A, Veskimäe E, Tuokko A, Kumpulainen P, Koskimäki J, Keinänen TA, Häkkinen MR, Vepsäläinen J, Paavonen T, Lekkala J, Lehtimäki T, Tammela TL, Oksala NK
Detection of prostate cancer by an electronic nose: a proof of principle study.
J Urol ;192(1)230-4, 2014
PMID

van den Berg SM, de Moor MH, McGue M, Pettersson E, Terracciano A, Verweij KJ, Amin N, Derringer J, Esko T, van Grootheest G, Hansell NK, Huffman J, Konte B, Lahti J, Luciano M, Matteson LK, Viktorin A, Wouda J, Agrawal A, Allik J, Bierut L, Broms U, Campbell H, Smith GD, Eriksson JG, Ferrucci L, Franke B, Fox JP, de Geus EJ, Giegling I, Gow AJ, Grucza R, Hartmann AM, Heath AC, Heikkilä K, Iacono WG, Janzing J, Jokela M, Kiemeney L, Lehtimäki T, Madden PA, Magnusson PK, Northstone K, Nutile T, Ouwens KG, Palotie A, Pattie A, Pesonen AK, Polasek O, Pulkkinen L, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Seppälä I, Slutske WS, Smyth DC, Sorice R, Starr JM, Sutin AR, Tanaka T, Verhagen J, Vermeulen S, Vuoksimaa E, Widen E, Willemsen G, Wright MJ, Zgaga L, Rujescu D, Metspalu A, Wilson JF, Ciullo M, Hayward C, Rudan I, Deary IJ, Räikkönen K, Arias Vasquez A, Costa PT, Keltikangas-Järvinen L, van Duijn CM, Penninx BW, Krueger R

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PMID

Behav Genet
44(4)
295-313 ;, 2014
PMID

Koskinen J, Magnussen CG, Sabin MA, Kähönen M, Hutri-Kähönen N, Laitinen T, Taittonen L, Jokinen E, Lehtimäki T, Viikari JS, Raitakari OT, Juonala M
Youth overweight and metabolic disturbances in predicting carotid intima-media thickness, type 2 diabetes, and metabolic syndrome in adulthood: the Cardiovascular Risk in Young Finns study.
Diabetes Care ;37(7)1870-7, 2014
PMID

Forssman L, Peltola MJ, Yrttiaho S, Puura K, Mononen N, Lehtimäki T, Leppänen JM
Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants.
J Child Psychol Psychiatry ;55(7)793-801, 2014
PMID

Raitoharju E, Seppälä I, Oksala N, Lyytikäinen LP, Raitakari O, Viikari J, Ala-Korpela M, Soininen P, Kangas AJ, Waldenberger M, Klopp N, Illig T, Leiviskä J, Loo BM, Hutri-Kähönen N, Kähönen M, Laaksonen R, Lehtimäki T
Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study.
Mol Cell Endocrinol ;391(1-2)41-9, 2014
PMID

Peltola MJ, Yrttiaho S, Puura K, Proverbio AM, Mononen N, Lehtimäki T, Leppänen JM
Motherhood and oxytocin receptor genetic variation are associated with selective changes in electrocortical responses to infant facial expressions.
Emotion ;14(3)469-77, 2014
PMID

Moayyeri A, Hsu YH, Karasik D, Estrada K, Xiao SM, Nielson C, Srikanth P, Giroux S, Wilson SG, Zheng HF, Smith AV, Pye SR, Leo PJ, Teumer A, Hwang JY, Ohlsson C, McGuigan F, Minster RL, Hayward C, Olmos JM, Lyytikäinen LP, Lewis JR, Swart KM, Masi L, Oldmeadow C, Holliday EG, Cheng S, van Schoor NM, Harvey NC, Kruk M, del Greco M F, Igl W, Trummer O, Grigoriou E, Luben R, Liu CT, Zhou Y, Oei L, Medina-Gomez C, Zmuda J, Tranah G, Brown SJ, Williams FM, Soranzo N, Jakobsdottir J, Siggeirsdottir K, Holliday KL, Hannemann A, Go MJ, Garcia M, Polasek O, Laaksonen M, Zhu K, Enneman AW, McEvoy M, Peel R, Sham PC, Jaworski M, Johansson Å, Hicks AA, Pludowski P, Scott R, Dhonukshe-Rutten RA, van der Velde N, Kähönen M, Viikari JS, Sievänen H, Raitakari OT, González-Macías J, Hernández JL, Mellström D, Ljunggren O, Cho YS, Völker U, Nauck M, Homuth G, Völzke H, Haring R, Brown MA, McCloskey E, Nicholson GC, Eastell R, Eisman JA, Jones G, Reid IR, Denni

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PMID

Hum Mol Genet
23(11)
3054-68 ;, 2014
PMID

Pradhapan P, Tarvainen MP, Nieminen T, Lehtinen R, Nikus K, Lehtimäki T, Kähönen M, Viik J
Effect of heart rate correction on pre- and post-exercise heart rate variability to predict risk of mortality-an experimental study on the FINCAVAS cohort.
Front Physiol ;2014
PMID

Ko A, Cantor RM, Weissglas-Volkov D, Nikkola E, Reddy PM, Sinsheimer JS, Pasaniuc B, Brown R, Alvarez M, Rodriguez A, Rodriguez-Guillen R, Bautista IC, Arellano-Campos O, Muñoz-Hernández LL, Salomaa V, Kaprio J, Jula A, Jauhiainen M, Heliövaara M, Raitakari O, Lehtimäki T, Eriksson JG, Perola M, Lohmueller KE, Matikainen N, Taskinen MR, Rodriguez-Torres M, Riba L, Tusie-Luna T, Aguilar-Salinas CA, Pajukanta P
Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.
Nat Commun ;2014
PMID

Saarelainen SK, Staff S, Peltonen N, Lehtimäki T, Isola J, Kujala PM, Vuento MH, Mäenpää JU
Endoglin, VEGF, and its receptors in predicting metastases in endometrial carcinoma.
Tumour Biol ;35(5)4651-7, 2014
PMID

Skilton MR, Siitonen N, Würtz P, Viikari JS, Juonala M, Seppälä I, Laitinen T, Lehtimäki T, Taittonen L, Kähönen M, Celermajer DS, Raitakari OT
High birth weight is associated with obesity and increased carotid wall thickness in young adults: the cardiovascular risk in young Finns study.
Arterioscler Thromb Vasc Biol ;34(5)1064-8, 2014
PMID

Pälve KS, Pahkala K, Magnussen CG, Koivistoinen T, Juonala M, Kähönen M, Lehtimäki T, Rönnemaa T, Viikari JS, Raitakari OT
Association of physical activity in childhood and early adulthood with carotid artery elasticity 21 years later: the cardiovascular risk in Young Finns Study.
J Am Heart Assoc ;3(2)e000594, 2014
PMID

Fan YM, Hernesniemi J, Oksala N, Levula M, Raitoharju E, Collings A, Hutri-Kähönen N, Juonala M, Marniemi J, Lyytikäinen LP, Seppälä I, Mennander A, Tarkka M, Kangas AJ, Soininen P, Salenius JP, Klopp N, Illig T, Laitinen T, Ala-Korpela M, Laaksonen R, Viikari J, Kähönen M, Raitakari OT, Lehtimäki T
Upstream Transcription Factor 1 (USF1) allelic variants regulate lipoprotein metabolism in women and USF1 expression in atherosclerotic plaque.
Sci Rep ;2014
PMID

Chumaeva N, Hintsanen M, Pulkki-Råback L, Jokela M, Juonala M, Lehtimäki T, Raitakari OT, Keltikangas-Järvinen L
Interleukin-6 gene polymorphism, chronic stress and atherosclerosis: interleukin-6-174G>C polymorphism, chronic stress and risk of early atherosclerosis in the Cardiovascular Risk in Young Finns Study.
J Psychosom Res ;76(4)333-8, 2014
PMID

Rizas KD, Nieminen T, Barthel P, Zürn CS, Kähönen M, Viik J, Lehtimäki T, Nikus K, Eick C, Greiner TO, Wendel HP, Seizer P, Schreieck J, Gawaz M, Schmidt G, Bauer A
Sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction.
J Clin Invest ;124(4)1770-80, 2014
PMID

Kemp JP, Sayers A, Paternoster L, Evans DM, Deere K, St Pourcain B, Timpson NJ, Ring SM, Lorentzon M, Lehtimäki T, Eriksson J, Kähönen M, Raitakari O, Laaksonen M, Sievänen H, Viikari J, Lyytikäinen LP, Smith GD, Fraser WD, Vandenput L, Ohlsson C, Tobias JH
Does bone resorption stimulate periosteal expansion? A cross-sectional analysis of β-C-telopeptides of type I collagen (CTX), genetic markers of the RANKL pathway, and periosteal circumference as measured by pQCT.
J Bone Miner Res ;29(4)1015-24, 2014
PMID

Hulkkonen J, Aatola H, Pälve K, Lehtimäki T, Hutri-Kähönen N, Viikari JS, Raitakari OT, Kähönen M
Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study.
BMC Cardiovasc Disord ;2014
PMID

Aatola H, Hutri-Kähönen N, Juonala M, Laitinen TT, Pahkala K, Mikkilä V, Telama R, Koivistoinen T, Lehtimäki T, Viikari JS, Raitakari OT, Kähönen M
Prospective relationship of change in ideal cardiovascular health status and arterial stiffness: the Cardiovascular Risk in Young Finns Study.
J Am Heart Assoc ;3(2)e000532, 2014
PMID

Jylhävä J, Lehtimäki T, Jula A, Moilanen L, Kesäniemi YA, Nieminen MS, Kähönen M, Hurme M
Circulating cell-free DNA is associated with cardiometabolic risk factors: the Health 2000 Survey.
Atherosclerosis ;233(1)268-71, 2014
PMID

Lemaitre RN, Johnson CO, Hesselson S, Sotoodehnia N, Sotoodhenia N, McKnight B, Sitlani CM, Rea TD, King IB, Kwok PY, Mak A, Li G, Brody J, Larson E, Mozaffarian D, Psaty BM, Huertas-Vazquez A, Tardif JC, Albert CM, Lyytikäinen LP, Arking DE, Kääb S, Huikuri HV, Krijthe BP, Eijgelsheim M, Wang YA, Reinier K, Lehtimäki T, Pulit SL, Brugada R, Müller-Nurasyid M, Newton-Cheh CH, Karhunen PJ, Stricker BH, Goyette P, Rotter JI, Chugh SS, Chakravarti A, Jouven X, Siscovick DS
Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest.
Heart Rhythm ;11(3)471-7, 2014
PMID

Skuse DH, Lori A, Cubells JF, Lee I, Conneely KN, Puura K, Lehtimäki T, Binder EB, Young LJ
Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills.
Proc Natl Acad Sci U S A ;111(5)1987-92, 2014
PMID

Silbernagel G, Chapman MJ, Genser B, Kleber ME, Fauler G, Scharnagl H, Grammer TB, Mäkelä KM, Kähönen M, Carmena R, Rietzschel ER, Bruckert E, Deanfield JE, Raitakari OT, Lehtimäki T, März W
Reply: Intestinal cholesterol absorption and cardiovascular risk.
J Am Coll Cardiol ;63(7)696-697, 2014
PMID

Viikki M, Kampman O, Seppälä N, Mononen N, Lehtimäki T, Leinonen E
CYP1A2 polymorphism -1545C > T (rs2470890) is associated with increased side effects to clozapine.
BMC Psychiatry ;2014
PMID

Tukiainen T, Pirinen M, Sarin AP, Ladenvall C, Kettunen J, Lehtimäki T, Lokki ML, Perola M, Sinisalo J, Vlachopoulou E, Eriksson JG, Groop L, Jula A, Järvelin MR, Raitakari OT, Salomaa V, Ripatti S
Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.
PLoS Genet ;10(2)e1004127, 2014
PMID

Immonen H, Hannukainen JC, Iozzo P, Soinio M, Salminen P, Saunavaara V, Borra R, Parkkola R, Mari A, Lehtimäki T, Pham T, Laine J, Kärjä V, Pihlajamäki J, Nelimarkka L, Nuutila P
Effect of bariatric surgery on liver glucose metabolism in morbidly obese diabetic and non-diabetic patients.
J Hepatol ;60(2)377-83, 2014
PMID

Kurki MI, Gaál EI, Kettunen J, Lappalainen T, Menelaou A, Anttila V, van 't Hof FN, von Und Zu Fraunberg M, Helisalmi S, Hiltunen M, Lehto H, Laakso A, Kivisaari R, Koivisto T, Ronkainen A, Rinne J, Kiemeney LA, Vermeulen SH, Kaunisto MA, Eriksson JG, Aromaa A, Perola M, Lehtimäki T, Raitakari OT, Salomaa V, Gunel M, Dermitzakis ET, Ruigrok YM, Rinkel GJ, Niemelä M, Hernesniemi J, Ripatti S, de Bakker PI, Palotie A, Jääskeläinen JE
High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms.
PLoS Genet ;10(1)e1004134, 2014
PMID

2013

Oksala N, Pärssinen J, Seppälä I, Raitoharju E, Kholova I, Ivana K, Hernesniemi J, Lyytikäinen LP, Levula M, Mäkelä KM, Sioris T, Kähönen M, Laaksonen R, Hytönen V, Lehtimäki T
Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s): Tampere Vascular Study (TVS).
Circ Cardiovasc Genet ;6(6)579-87, 2013
PMID

Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen LP, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Fran

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PMID

Genet Epidemiol
37(8)
846-59 ;, 2013
PMID

Häkkinen MR, Roine A, Auriola S, Tuokko A, Veskimäe E, Keinänen TA, Lehtimäki T, Oksala N, Vepsäläinen J
Analysis of free, mono- and diacetylated polyamines from human urine by LC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci ;2013
PMID

Kresanov P, Ahotupa M, Vasankari T, Kaikkonen J, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT
The associations of oxidized high-density lipoprotein lipids with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study.
Free Radic Biol Med ;2013
PMID

Parsa A, Fuchsberger C, Köttgen A, O'Seaghdha CM, Pattaro C, de Andrade M, Chasman DI, Teumer A, Endlich K, Olden M, Chen MH, Tin A, Kim YJ, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster MC, Glazer N, Isaacs A, Rao M, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Couraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra BA, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Döring A, Wichmann HE, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck M, Stracke S, Völker U, Völzk

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PMID

J Am Soc Nephrol
24(12)
2105-17 ;, 2013
PMID

Raitoharju E, Oksala N, Lehtimäki T
MicroRNAs in the atherosclerotic plaque.
Clin Chem ;59(12)1708-21, 2013
PMID

Hakulinen C, Jokela M, Hintsanen M, Merjonen P, Pulkki-Råback L, Seppälä I, Lyytikäinen LP, Lehtimäki T, Kähönen M, Viikari J, Raitakari OT, Keltikangas-Järvinen L
Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study.
J Behav Med ;36(6)583-90, 2013
PMID

Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikäinen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodar

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PMID



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PMID



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PMID

Nat Genet
45(11)
1345-52 ;, 2013
PMID

Würtz P, Kangas AJ, Soininen P, Lehtimäki T, Kähönen M, Viikari JS, Raitakari OT, Järvelin MR, Davey Smith G, Ala-Korpela M
Lipoprotein subclass profiling reveals pleiotropy in the genetic variants of lipid risk factors for coronary heart disease: a note on Mendelian randomization studies.
J Am Coll Cardiol ;62(20)1906-8, 2013
PMID

Koskela JK, Tahvanainen A, Haring A, Tikkakoski AJ, Ilveskoski E, Viitala J, Leskinen MH, Lehtimäki T, Kähönen MA, Kööbi T, Niemelä O, Mustonen JT, Pörsti IH
Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects.
BMC Cardiovasc Disord ;2013
PMID

Kämppä N, Mäkelä KM, Lyytikäinen LP, Peltonen N, Hautamäki J, Seppälä I, Mononen N, Goebeler S, Karhunen PJ, Hervonen A, Hurme M, Jylhä M, Lehtimäki T
Vascular cell adhesion molecule 1, soluble Fas and hepatocyte growth factor as predictors of mortality in nonagenarians: the Vitality 90+ study.
Exp Gerontol ;48(11)1167-72, 2013
PMID

Pessi T, Karhunen V, Karjalainen PP, Ylitalo A, Airaksinen JK, Niemi M, Pietila M, Lounatmaa K, Haapaniemi T, Lehtimäki T, Laaksonen R, Karhunen PJ, Mikkelsson J
Response to letters regarding article, "Bacterial signatures in thrombus aspirates of patients with myocardial infarction".
Circulation ;128(15)e237-8, 2013
PMID

Kleber ME, Seppälä I, Pilz S, Hoffmann MM, Tomaschitz A, Oksala N, Raitoharju E, Lyytikäinen LP, Mäkelä KM, Laaksonen R, Kähönen M, Raitakari OT, Huang J, Kienreich K, Fahrleitner-Pammer A, Drechsler C, Krane V, Boehm BO, Koenig W, Wanner C, Lehtimäki T, März W, Meinitzer A
Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium.
Circ Cardiovasc Genet ;6(5)505-13, 2013
PMID

Stoll G, Pietiläinen OPH, Linder B, Suvisaari J, Brosi C, Hennah W, Leppä V, Torniainen M, Ripatti S, Ala-Mello S, Plöttner O, Rehnström K, Tuulio-Henriksson A, Varilo T, Tallila J, Kristiansson K, Isohanni M, Kaprio J, Eriksson JG, Raitakari OT, Lehtimäki T, Jarvelin MR, Salomaa V, Hurles M, Stefansson H, Peltonen L, Sullivan PF, Paunio T, Lönnqvist J, Daly MJ, Fischer U, Freimer NB, Palotie A
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders.
Nat Neurosci ;16(9)1228-1237, 2013
PMID

Saarelainen SK, Peltonen N, Lehtimäki T, Perheentupa A, Vuento MH, Mäenpää JU
Predictive value of serum human epididymis protein 4 and cancer antigen 125 concentrations in endometrial carcinoma.
Am J Obstet Gynecol ;209(2)142.e1-6, 2013
PMID

Aatola H, Magnussen CG, Koivistoinen T, Hutri-Kähönen N, Juonala M, Viikari JS, Lehtimäki T, Raitakari OT, Kähönen M
Simplified definitions of elevated pediatric blood pressure and high adult arterial stiffness.
Pediatrics ;132(1)e70-6, 2013
PMID

Silbernagel G, Chapman MJ, Genser B, Kleber ME, Fauler G, Scharnagl H, Grammer TB, Boehm BO, Mäkelä KM, Kähönen M, Carmena R, Rietzschel ER, Bruckert E, Deanfield JE, Miettinen TA, Raitakari OT, Lehtimäki T, März W
High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis.
J Am Coll Cardiol ;62(4)291-9, 2013
PMID

Tanaka T, Ngwa JS, van Rooij FJ, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S, Lemaitre RN, Luan J, Mikkilä V, Renstrom F, Sonestedt E, Zhao JH, Chu AY, Qi L, Chasman DI, de Oliveira Otto MC, Dhurandhar EJ, Feitosa MF, Johansson I, Khaw KT, Lohman KK, Manichaikul A, McKeown NM, Mozaffarian D, Singleton A, Stirrups K, Viikari J, Ye Z, Bandinelli S, Barroso I, Deloukas P, Forouhi NG, Hofman A, Liu Y, Lyytikäinen LP, North KE, Dimitriou M, Hallmans G, Kähönen M, Langenberg C, Ordovas JM, Uitterlinden AG, Hu FB, Kalafati IP, Raitakari O, Franco OH, Johnson A, Emilsson V, Schrack JA, Semba RD, Siscovick DS, Arnett DK, Borecki IB, Franks PW, Kritchevsky SB, Lehtimäki T, Loos RJ, Orho-Melander M, Rotter JI, Wareham NJ, Witteman JC, Ferrucci L, Dedoussis G, Cupples LA, Nettleton JA
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.
Am J Clin Nutr ;97(6)1395-402, 2013
PMID

Viikki ML, Järventausta K, Leinonen E, Huuhka M, Mononen N, Lehtimäki T, Kampman O
BDNF polymorphism rs11030101 is associated with the efficacy of electroconvulsive therapy in treatment-resistant depression.
Psychiatr Genet ;23(3)134-6, 2013
PMID

Hällfors J, Loukola A, Pitkäniemi J, Broms U, Männistö S, Salomaa V, Heliövaara M, Lehtimäki T, Raitakari O, Madden PA, Heath AC, Montgomery GW, Martin NG, Korhonen T, Kaprio J
Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study.
Int J Mol Epidemiol Genet ;4(2)109-19, 2013
PMID

Jänis MT, Tarasov K, Ta HX, Suoniemi M, Ekroos K, Hurme R, Lehtimäki T, Päivä H, Kleber ME, März W, Prat A, Seidah NG, Laaksonen R
Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency.
Atherosclerosis ;228(2)380-5, 2013
PMID

Solakivi T, Kunnas T, Jaakkola O, Renko J, Lehtimäki T, Nikkari ST
Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro.
Lipids Health Dis ;2013
PMID

Kaikkonen JE, Jula A, Mikkilä V, Juonala M, Viikari JS, Moilanen T, Nikkari T, Kähönen M, Lehtimäki T, Raitakari OT
Childhood serum fatty acid quality is associated with adult carotid artery intima media thickness in women but not in men.
J Nutr ;143(5)682-9, 2013
PMID

Markus HS, Mäkelä KM, Bevan S, Raitoharju E, Oksala N, Bis JC, O'Donnell C, Hainsworth A, Lehtimäki T
Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis.
Stroke ;44(5)1220-5, 2013
PMID

Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, Esko T, Fall T, Ferreira T, Gentilini D, Jackson AU, Luan J, Randall JC, Vedantam S, Willer CJ, Winkler TW, Wood AR, Workalemahu T, Hu YJ, Lee SH, Liang L, Lin DY, Min JL, Neale BM, Thorleifsson G, Yang J, Albrecht E, Amin N, Bragg-Gresham JL, Cadby G, den Heijer M, Eklund N, Fischer K, Goel A, Hottenga JJ, Huffman JE, Jarick I, Johansson Å, Johnson T, Kanoni S, Kleber ME, König IR, Kristiansson K, Kutalik Z, Lamina C, Lecoeur C, Li G, Mangino M, McArdle WL, Medina-Gomez C, Müller-Nurasyid M, Ngwa JS, Nolte IM, Paternoster L, Pechlivanis S, Perola M, Peters MJ, Preuss M, Rose LM, Shi J, Shungin D, Smith AV, Strawbridge RJ, Surakka I, Teumer A, Trip MD, Tyrer J, Van Vliet-Ostaptchouk JV, Vandenput L, Waite LL, Zhao JH, Absher D, Asselbergs FW, Atalay M, Attwood AP, Balmforth AJ, Basart H, Beilby J, Bonnycastle LL, Brambilla P, Bruinenberg

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PMID



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PMID

Nat Genet
45(5)
501-12 ;, 2013
PMID

Juonala M, Jääskeläinen P, Sabin MA, Viikari JS, Kähönen M, Lehtimäki T, Seppälä I, Hutri-Kähönen N, Taittonen L, Jokinen E, Laitinen T, Magnussen CG, Raitakari OT
Higher maternal body mass index is associated with an increased risk for later type 2 diabetes in offspring.
J Pediatr ;162(5)918-23.e1, 2013
PMID

Tyynelä P, Goebeler S, Ilveskoski E, Mikkelsson J, Perola M, Lehtimäki T, Karhunen PJ
Age-dependent interaction of apolipoprotein E gene with eastern birthplace in Finland affects severity of coronary atherosclerosis and risk of fatal myocardial infarction--Helsinki Sudden Death Study.
Ann Med ;45(3)213-9, 2013
PMID

Laurila PP, Surakka I, Sarin AP, Yetukuri L, Hyötyläinen T, Söderlund S, Naukkarinen J, Tang J, Kettunen J, Mirel DB, Soronen J, Lehtimäki T, Ruokonen A, Ehnholm C, Eriksson JG, Salomaa V, Jula A, Raitakari OT, Järvelin MR, Palotie A, Peltonen L, Oresic M, Jauhiainen M, Taskinen MR, Ripatti S
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol.
Arterioscler Thromb Vasc Biol ;33(4)847-57, 2013
PMID

Andre K, Kampman O, Viikki M, Illi A, Setälä-Soikkeli E, Poutanen O, Mononen N, Leinonen E, Lehtimäki T
TPH1 A218C polymorphism and temperament in major depression.
BMC Psychiatry ;2013
PMID

van der Loos MJ, Rietveld CA, Eklund N, Koellinger PD, Rivadeneira F, Abecasis GR, Ankra-Badu GA, Baumeister SE, Benjamin DJ, Biffar R, Blankenberg S, Boomsma DI, Cesarini D, Cucca F, de Geus EJ, Dedoussis G, Deloukas P, Dimitriou M, Eiriksdottir G, Eriksson J, Gieger C, Gudnason V, Höhne B, Holle R, Hottenga JJ, Isaacs A, Järvelin MR, Johannesson M, Kaakinen M, Kähönen M, Kanoni S, Laaksonen MA, Lahti J, Launer LJ, Lehtimäki T, Loitfelder M, Magnusson PK, Naitza S, Oostra BA, Perola M, Petrovic K, Quaye L, Raitakari O, Ripatti S, Scheet P, Schlessinger D, Schmidt CO, Schmidt H, Schmidt R, Senft A, Smith AV, Spector TD, Surakka I, Svento R, Terracciano A, Tikkanen E, van Duijn CM, Viikari J, Völzke H, Wichmann HE, Wild PS, Willems SM, Willemsen G, van Rooij FJ, Groenen PJ, Uitterlinden AG, Hofman A, Thurik AR
The molecular genetic architecture of self-employment.
PLoS One ;8(4)e60542, 2013
PMID

Pessi T, Karhunen V, Karjalainen PP, Ylitalo A, Airaksinen JK, Niemi M, Pietila M, Lounatmaa K, Haapaniemi T, Lehtimäki T, Laaksonen R, Karhunen PJ, Mikkelsson J
Bacterial signatures in thrombus aspirates of patients with myocardial infarction.
Circulation ;127(11)1219-28, e1-6, 2013
PMID

Hruby A, Ngwa JS, Renström F, Wojczynski MK, Ganna A, Hallmans G, Houston DK, Jacques PF, Kanoni S, Lehtimäki T, Lemaitre RN, Manichaikul A, North KE, Ntalla I, Sonestedt E, Tanaka T, van Rooij FJ, Bandinelli S, Djoussé L, Grigoriou E, Johansson I, Lohman KK, Pankow JS, Raitakari OT, Riserus U, Yannakoulia M, Zillikens MC, Hassanali N, Liu Y, Mozaffarian D, Papoutsakis C, Syvänen AC, Uitterlinden AG, Viikari J, Groves CJ, Hofman A, Lind L, McCarthy MI, Mikkilä V, Mukamal K, Franco OH, Borecki IB, Cupples LA, Dedoussis GV, Ferrucci L, Hu FB, Ingelsson E, Kähönen M, Kao WH, Kritchevsky SB, Orho-Melander M, Prokopenko I, Rotter JI, Siscovick DS, Witteman JC, Franks PW, Meigs JB, McKeown NM, Nettleton JA
Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE Consortium Studies.
J Nutr ;143(3)345-53, 2013
PMID

Würtz P, Soininen P, Kangas AJ, Rönnemaa T, Lehtimäki T, Kähönen M, Viikari JS, Raitakari OT, Ala-Korpela M
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults.
Diabetes Care ;36(3)648-55, 2013
PMID

Oksala N, Seppälä I, Hernesniemi J, Lyytikäinen LP, Kähönen M, Mäkelä KM, Reunanen A, Jula A, Ala-Korpela M, Lehtimäki T
Complementary prediction of cardiovascular events by estimated apo- and lipoprotein concentrations in the working age population. The Health 2000 Study.
Ann Med ;45(2)141-8, 2013
PMID

Illi A, Viikki M, Poutanen O, Setälä-Soikkeli E, Nuolivirta T, Kampman O, Leinonen E, Huhtala H, Mononen N, Lehtimäki T
No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in major depressive disorder or antidepressant response in patients of Finnish origin.
Psychiatr Genet ;23(1)33-5, 2013
PMID

Mäkelä KM, Seppälä I, Hernesniemi JA, Lyytikäinen LP, Oksala N, Kleber ME, Scharnagl H, Grammer TB, Baumert J, Thorand B, Jula A, Hutri-Kähönen N, Juonala M, Laitinen T, Laaksonen R, Karhunen PJ, Nikus KC, Nieminen T, Laurikka J, Kuukasjärvi P, Tarkka M, Viik J, Klopp N, Illig T, Kettunen J, Ahotupa M, Viikari JS, Kähönen M, Raitakari OT, Karakas M, Koenig W, Boehm BO, Winkelmann BR, März W, Lehtimäki T
Genome-wide association study pinpoints a new functional apolipoprotein B variant influencing oxidized low-density lipoprotein levels but not cardiovascular events: AtheroRemo Consortium.
Circ Cardiovasc Genet ;6(1)73-81, 2013
PMID

Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka SK, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FR, Visser PJ, Soininen H, Hiltunen M
Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.
PLoS One ;8(4)e59676, 2013
PMID

Paternoster L, Lorentzon M, Lehtimäki T, Eriksson J, Kähönen M, Raitakari O, Laaksonen M, Sievänen H, Viikari J, Lyytikäinen LP, Mellström D, Karlsson M, Ljunggren O, Grundberg E, Kemp JP, Sayers A, Nethander M, Evans DM, Vandenput L, Tobias JH, Ohlsson C
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.
PLoS Genet ;9(2)e1003247, 2013
PMID

Kujala UM, Mäkinen VP, Heinonen I, Soininen P, Kangas AJ, Leskinen TH, Rahkila P, Würtz P, Kovanen V, Cheng S, Sipilä S, Hirvensalo M, Telama R, Tammelin T, Savolainen MJ, Pouta A, O'Reilly PF, Mäntyselkä P, Viikari J, Kähönen M, Lehtimäki T, Elliott P, Vanhala MJ, Raitakari OT, Järvelin MR, Kaprio J, Kainulainen H, Ala-Korpela M
Long-term leisure-time physical activity and serum metabolome.
Circulation ;127(3)340-8, 2013
PMID

Nettleton JA, Hivert MF, Lemaitre RN, McKeown NM, Mozaffarian D, Tanaka T, Wojczynski MK, Hruby A, Djoussé L, Ngwa JS, Follis JL, Dimitriou M, Ganna A, Houston DK, Kanoni S, Mikkilä V, Manichaikul A, Ntalla I, Renström F, Sonestedt E, van Rooij FJ, Bandinelli S, de Koning L, Ericson U, Hassanali N, Kiefte-de Jong JC, Lohman KK, Raitakari O, Papoutsakis C, Sjogren P, Stirrups K, Ax E, Deloukas P, Groves CJ, Jacques PF, Johansson I, Liu Y, McCarthy MI, North K, Viikari J, Zillikens MC, Dupuis J, Hofman A, Kolovou G, Mukamal K, Prokopenko I, Rolandsson O, Seppälä I, Cupples LA, Hu FB, Kähönen M, Uitterlinden AG, Borecki IB, Ferrucci L, Jacobs DR, Kritchevsky SB, Orho-Melander M, Pankow JS, Lehtimäki T, Witteman JC, Ingelsson E, Siscovick DS, Dedoussis G, Meigs JB, Franks PW
Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from
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PMID

177(2)
103-15
, 2013 ;
PMID

Richardson K, Nettleton JA, Rotllan N, Tanaka T, Smith CE, Lai CQ, Parnell LD, Lee YC, Lahti J, Lemaitre RN, Manichaikul A, Keller M, Mikkilä V, Ngwa J, van Rooij FJ, Ballentyne CM, Borecki IB, Cupples LA, Garcia M, Hofman A, Ferrucci L, Mozaffarian D, Perälä MM, Raitakari O, Tracy RP, Arnett DK, Bandinelli S, Boerwinkle E, Eriksson JG, Franco OH, Kähönen M, Nalls M, Siscovick DS, Houston DK, Psaty BM, Viikari J, Witteman JC, Goodarzi MO, Lehtimäki T, Liu Y, Zillikens MC, Chen YD, Uitterlinden AG, Rotter JI, Fernandez-Hernando C, Ordovas JM
Gain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.
Am J Hum Genet ;92(1)5-14, 2013
PMID

Raitoharju E, Seppälä I, Lyytikäinen LP, Levula M, Oksala N, Klopp N, Illig T, Laaksonen R, Kähönen M, Lehtimäki T
A comparison of the accuracy of Illumina HumanHT-12 v3 Expression BeadChip and TaqMan qRT-PCR gene expression results in patient samples from the Tampere Vascular Study.
Atherosclerosis ;226(1)149-52, 2013
PMID

Raitakari OT, Mäkinen VP, McQueen MJ, Niemi J, Juonala M, Jauhiainen M, Salomaa V, Hannuksela ML, Savolainen MJ, Kesäniemi YA, Kovanen PT, Sundvall J, Solakivi T, Loo BM, Marniemi J, Hernesniemi J, Lehtimäki T, Kähönen M, Peltonen M, Leiviskä J, Jula A, Anand SS, Miller R, Yusuf S, Viikari JS, Ala-Korpela M
Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk.
Atherosclerosis ;226(1)245-51, 2013
PMID

Viiri LE, Full LE, Navin TJ, Begum S, Didangelos A, Astola N, Berge RK, Seppälä I, Shalhoub J, Franklin IJ, Perretti M, Lehtimäki T, Davies AH, Wait R, Monaco C
Smooth muscle cells in human atherosclerosis: proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease.
J Mol Cell Cardiol ;2013
PMID

Skilton MR, Mikkilä V, Würtz P, Ala-Korpela M, Sim KA, Soininen P, Kangas AJ, Viikari JS, Juonala M, Laitinen T, Lehtimäki T, Taittonen L, Kähönen M, Celermajer DS, Raitakari OT
Fetal growth, omega-3 (n-3) fatty acids, and progression of subclinical atherosclerosis: preventing fetal origins of disease? The Cardiovascular Risk in Young Finns Study.
Am J Clin Nutr ;97(1)58-65, 2013
PMID

2012

Koskinen J, Magnussen CG, Würtz P, Soininen P, Kangas AJ, Viikari JS, Kähönen M, Loo BM, Jula A, Ahotupa M, Lehtimäki T, Ala-Korpela M, Juonala M, Raitakari OT
Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle size in predicting the incidence of metabolic syndrome: the Cardiovascular Risk in Young Finns study.
Eur J Prev Cardiol ;19(6)1296-303, 2012
PMID

Oikonen M, Wendelin-Saarenhovi M, Siitonen N, Sainio A, Juonala M, Kähönen M, Lyytikäinen LP, Seppälä I, Lehtimäki T, Viikari JS, Järveläinen H, Raitakari OT
Tissue inhibitor of matrix metalloproteinases 4 (TIMP4) in a population of young adults: relations to cardiovascular risk markers and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study.
Scand J Clin Lab Invest ;72(7)540-6, 2012
PMID

van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, Al-Hussani A, Asselbergs FW, Ciullo M, Danjou F, Dina C, Esko T, Evans DM, Franke L, Gögele M, Hartiala J, Hersch M, Holm H, Hottenga JJ, Kanoni S, Kleber ME, Lagou V, Langenberg C, Lopez LM, Lyytikäinen LP, Melander O, Murgia F, Nolte IM, O'Reilly PF, Padmanabhan S, Parsa A, Pirastu N, Porcu E, Portas L, Prokopenko I, Ried JS, Shin SY, Tang CS, Teumer A, Traglia M, Ulivi S, Westra HJ, Yang J, Zhao JH, Anni F, Abdellaoui A, Attwood A, Balkau B, Bandinelli S, Bastardot F, Benyamin B, Boehm BO, Cookson WO, Das D, de Bakker PI, de Boer RA, de Geus EJ, de Moor MH, Dimitriou M, Domingues FS, Döring A, Engström G, Eyjolfsson GI, Ferrucci L, Fischer K, Galanello R, Garner SF, Genser B, Gibson QD, Girotto G, Gudbjartsson DF, Harris SE, Hartikainen AL, Hastie CE, Hedblad B, Illig T, Joll

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PMID



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PMID

Nature
492(7429)
369-75 ;, 2012
PMID

Magnussen CG, Koskinen J, Juonala M, Chen W, Srinivasan SR, Sabin MA, Thomson R, Schmidt MD, Nguyen QM, Xu JH, Skilton MR, Kähönen M, Laitinen T, Taittonen L, Lehtimäki T, Rönnemaa T, Viikari JS, Berenson GS, Raitakari OT
A diagnosis of the metabolic syndrome in youth that resolves by adult life is associated with a normalization of high carotid intima-media thickness and type 2 diabetes mellitus risk: the Bogalusa heart and cardiovascular risk in young Finns studies.
J Am Coll Cardiol ;60(17)1631-9, 2012
PMID

Hartiala O, Magnussen CG, Kajander S, Knuuti J, Ukkonen H, Saraste A, Rinta-Kiikka I, Kainulainen S, Kähönen M, Hutri-Kähönen N, Laitinen T, Lehtimäki T, Viikari JS, Hartiala J, Juonala M, Raitakari OT
Adolescence risk factors are predictive of coronary artery calcification at middle age: the cardiovascular risk in young Finns study.
J Am Coll Cardiol ;60(15)1364-70, 2012
PMID

Isotalo K, Kok EH, Luoto TM, Haikonen S, Haapasalo H, Lehtimäki T, Karhunen PJ
Upstream transcription factor 1 (USF1) polymorphisms associate with Alzheimer's disease-related neuropathological lesions: Tampere Autopsy Study.
Brain Pathol ;22(6)765-75, 2012
PMID

Mansikkaniemi K, Juonala M, Taimela S, Hirvensalo M, Telama R, Huupponen R, Saarikoski L, Hurme M, Mallat Z, Benessiano J, Jula A, Taittonen L, Marniemi J, Kähönen M, Lehtimäki T, Rönnemaa T, Viikari J, Raitakari OT
Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study.
Ann Med ;44(7)733-44, 2012
PMID

Roine A, Tolvanen M, Sipiläinen M, Kumpulainen P, Helenius MA, Lehtimäki T, Vepsäläinen J, Keinänen TA, Häkkinen MR, Koskimäki J, Veskimäe E, Tuokko A, Visakorpi T, Tammela TL, Sioris T, Paavonen T, Lekkala J, Helle H, Oksala NK
Detection of smell print differences between nonmalignant and malignant prostate cells with an electronic nose.
Future Oncol ;8(9)1157-65, 2012
PMID

Elovainio M, Hurme M, Jokela M, Pulkki-Råback L, Kivimäki M, Hintsanen M, Hintsa T, Lehtimäki T, Viikari J, Raitakari OT, Keltikangas-Järvinen L
Indoleamine 2,3-dioxygenase activation and depressive symptoms: results from the Young Finns Study.
Psychosom Med ;74(7)675-81, 2012
PMID

Verhoeven VJ, Hysi PG, Saw SM, Vitart V, Mirshahi A, Guggenheim JA, Cotch MF, Yamashiro K, Baird PN, Mackey DA, Wojciechowski R, Ikram MK, Hewitt AW, Duggal P, Janmahasatian S, Khor CC, Fan Q, Zhou X, Young TL, Tai ES, Goh LK, Li YJ, Aung T, Vithana E, Teo YY, Tay W, Sim X, Rudan I, Hayward C, Wright AF, Polasek O, Campbell H, Wilson JF, Fleck BW, Nakata I, Yoshimura N, Yamada R, Matsuda F, Ohno-Matsui K, Nag A, McMahon G, St Pourcain B, Lu Y, Rahi JS, Cumberland PM, Bhattacharya S, Simpson CL, Atwood LD, Li X, Raffel LJ, Murgia F, Portas L, Despriet DD, van Koolwijk LM, Wolfram C, Lackner KJ, Tönjes A, Mägi R, Lehtimäki T, Kähönen M, Esko T, Metspalu A, Rantanen T, Pärssinen O, Klein BE, Meitinger T, Spector TD, Oostra BA, Smith AV, de Jong PT, Hofman A, Amin N, Karssen LC, Rivadeneira F, Vingerling JR, Eiríksdóttir G, Gudnason V, Döring A, Bettecken T, Uitterlinden AG, Williams C, Zeller T, Castagné R, Oexle K, van Duijn CM, Iyengar SK, Mi

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PMID

Hum Genet
131(9)
1467-80 ;, 2012
PMID

Verweij KJ, Yang J, Lahti J, Veijola J, Hintsanen M, Pulkki-Råback L, Heinonen K, Pouta A, Pesonen AK, Widen E, Taanila A, Isohanni M, Miettunen J, Palotie A, Penke L, Service SK, Heath AC, Montgomery GW, Raitakari O, Kähönen M, Viikari J, Räikkönen K, Eriksson JG, Keltikangas-Järvinen L, Lehtimäki T, Martin NG, Järvelin MR, Visscher PM, Keller MC, Zietsch BP
Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding.
Evolution ;66(10)3238-51, 2012
PMID

Lisko I, Tiainen K, Stenholm S, Luukkaala T, Hurme M, Lehtimäki T, Hervonen A, Jylhä M
Inflammation, adiposity, and mortality in the oldest old.
Rejuvenation Res ;15(5)445-52, 2012
PMID

Sinner MF, Porthan K, Noseworthy PA, Havulinna AS, Tikkanen JT, Müller-Nurasyid M, Peloso G, Ulivi S, Beckmann BM, Brockhaus AC, Cooper RR, Gasparini P, Hengstenberg C, Hwang SJ, Iorio A, Junttila MJ, Klopp N, Kähönen M, Laaksonen MA, Lehtimäki T, Lichtner P, Lyytikäinen LP, Martens E, Meisinger C, Meitinger T, Merchant FM, Nieminen MS, Peters A, Pietilä A, Perz S, Oikarinen L, Raitakari O, Reinhard W, Silander K, Thorand B, Wichmann HE, Sinagra G, Viikari J, O'Donnell CJ, Ellinor PT, Huikuri HV, Kääb S, Newton-Cheh C, Salomaa V
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
Heart Rhythm ;9(10)1627-34, 2012
PMID

Koskinen J, Magnussen CG, Viikari JS, Kähönen M, Laitinen T, Hutri-Kähönen N, Lehtimäki T, Jokinen E, Raitakari OT, Juonala M
Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6-year follow-up. The cardiovascular risk in Young Finns study.
Atherosclerosis ;224(2)474-9, 2012
PMID

Hartz SM, Short SE, Saccone NL, Culverhouse R, Chen L, Schwantes-An TH, Coon H, Han Y, Stephens SH, Sun J, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Geller F, Gubjartsson D, Hansel NN, Jiang C, Keskitalo-Vuokko K, Liu Z, Lyytikäinen LP, Michel M, Rawal R, Rosenberger A, Scheet P, Shaffer JR, Teumer A, Thompson JR, Vink JM, Vogelzangs N, Wenzlaff AS, Wheeler W, Xiao X, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty T, Bennett S, Bergen AW, Boyd HA, Broms U, Campbell H, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick DM, Foroud T, Furberg H, Giegling I, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Hayward C, Heikkilä K, Hewitt JK, Hottenga JJ, Jensen MK, Jousilahti P, Kaakinen M, Kittner SJ, Konte B, Korhonen T, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Muley T, Murray T, Nauck M, North K, Pergadia M, Polasek O, Ramos EM, Ripatti S, Risch A, Ruczinski I, Rudan I, Sa

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PMID

Arch Gen Psychiatry
69(8)
854-60 ;, 2012
PMID

Salagianni M, Galani IE, Lundberg AM, Davos CH, Varela A, Gavriil A, Lyytikäinen LP, Lehtimäki T, Sigala F, Folkersen L, Gorgoulis V, Lenglet S, Montecucco F, Mach F, Hedin U, Hansson GK, Monaco C, Andreakos E
Toll-like receptor 7 protects from atherosclerosis by constraining "inflammatory" macrophage activation.
Circulation ;126(8)952-62, 2012
PMID

Oikonen M, Wendelin-Saarenhovi M, Lyytikäinen LP, Siitonen N, Loo BM, Jula A, Seppälä I, Saarikoski L, Lehtimäki T, Hutri-Kähönen N, Juonala M, Kähönen M, Huupponen R, Viikari JS, Raitakari OT
Associations between serum uric acid and markers of subclinical atherosclerosis in young adults. The cardiovascular risk in Young Finns study.
Atherosclerosis ;223(2)497-503, 2012
PMID

Raiko JR, Oikonen M, Wendelin-Saarenhovi M, Siitonen N, Kähönen M, Lehtimäki T, Viikari J, Jula A, Loo BM, Huupponen R, Saarikoski L, Juonala M, Raitakari OT
Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;224(1)208-12, 2012
PMID

Jääskeläinen P, Magnussen CG, Pahkala K, Mikkilä V, Kähönen M, Sabin MA, Fogelholm M, Hutri-Kähönen N, Taittonen L, Telama R, Laitinen T, Jokinen E, Lehtimäki T, Viikari JS, Raitakari OT, Juonala M
Childhood nutrition in predicting metabolic syndrome in adults: the cardiovascular risk in Young Finns Study.
Diabetes Care ;35(9)1937-43, 2012
PMID

Natarajan R, Einarsdottir E, Riutta A, Hagman S, Raunio M, Mononen N, Lehtimäki T, Elovaara I
Melatonin pathway genes are associated with progressive subtypes and disability status in multiple sclerosis among Finnish patients.
J Neuroimmunol ;250(1-2)106-10, 2012
PMID

Würtz P, Raiko JR, Magnussen CG, Soininen P, Kangas AJ, Tynkkynen T, Thomson R, Laatikainen R, Savolainen MJ, Laurikka J, Kuukasjärvi P, Tarkka M, Karhunen PJ, Jula A, Viikari JS, Kähönen M, Lehtimäki T, Juonala M, Ala-Korpela M, Raitakari OT
High-throughput quantification of circulating metabolites improves prediction of subclinical atherosclerosis.
Eur Heart J ;33(18)2307-16, 2012
PMID

Zheng HF, Tobias JH, Duncan E, Evans DM, Eriksson J, Paternoster L, Yerges-Armstrong LM, Lehtimäki T, Bergström U, Kähönen M, Leo PJ, Raitakari O, Laaksonen M, Nicholson GC, Viikari J, Ladouceur M, Lyytikäinen LP, Medina-Gomez C, Rivadeneira F, Prince RL, Sievanen H, Leslie WD, Mellström D, Eisman JA, Movérare-Skrtic S, Goltzman D, Hanley DA, Jones G, St Pourcain B, Xiao Y, Timpson NJ, Smith GD, Reid IR, Ring SM, Sambrook PN, Karlsson M, Dennison EM, Kemp JP, Danoy P, Sayers A, Wilson SG, Nethander M, McCloskey E, Vandenput L, Eastell R, Liu J, Spector T, Mitchell BD, Streeten EA, Brommage R, Pettersson-Kymmer U, Brown MA, Ohlsson C, Richards JB, Lorentzon M
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.
PLoS Genet ;8(7)e1002745, 2012
PMID

Juhola J, Oikonen M, Magnussen CG, Mikkilä V, Siitonen N, Jokinen E, Laitinen T, Würtz P, Gidding SS, Taittonen L, Seppälä I, Jula A, Kähönen M, Hutri-Kähönen N, Lehtimäki T, Viikari JS, Juonala M, Raitakari OT
Childhood physical, environmental, and genetic predictors of adult hypertension: the cardiovascular risk in young Finns study.
Circulation ;126(4)402-9, 2012
PMID

Lähteelä K, Kunnas T, Lyytikäinen LP, Mononen N, Taittonen L, Laitinen T, Kettunen J, Juonala M, Hutri-Kähönen N, Kähönen M, Viikari JS, Raitakari OT, Lehtimäki T, Nikkari ST
No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study.
BMC Med Genet ;2012
PMID

Kenttä T, Viik J, Karsikas M, Seppänen T, Nieminen T, Lehtimäki T, Nikus K, Lehtinen R, Kähönen M, Huikuri HV
Postexercise recovery of the spatial QRS/T angle as a predictor of sudden cardiac death.
Heart Rhythm ;9(7)1083-9, 2012
PMID

Würtz P, Tiainen M, Mäkinen VP, Kangas AJ, Soininen P, Saltevo J, Keinänen-Kiukaanniemi S, Mäntyselkä P, Lehtimäki T, Laakso M, Jula A, Kähönen M, Vanhala M, Ala-Korpela M
Circulating metabolite predictors of glycemia in middle-aged men and women.
Diabetes Care ;35(8)1749-56, 2012
PMID

Würtz P, Mäkinen VP, Soininen P, Kangas AJ, Tukiainen T, Kettunen J, Savolainen MJ, Tammelin T, Viikari JS, Rönnemaa T, Kähönen M, Lehtimäki T, Ripatti S, Raitakari OT, Järvelin MR, Ala-Korpela M
Metabolic signatures of insulin resistance in 7,098 young adults.
Diabetes ;61(6)1372-80, 2012
PMID

Jylhävä J, Jylhä M, Lehtimäki T, Hervonen A, Hurme M
Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: the Vitality 90+ Study.
Exp Gerontol ;47(5)372-8, 2012
PMID

Kaikkonen JE, Jula A, Mikkilä V, Viikari JS, Moilanen T, Nikkari T, Kähönen M, Lehtimäki T, Raitakari OT
Childhood serum cholesterol ester fatty acids are associated with blood pressure 27 y later in the Cardiovascular Risk in Young Finns Study.
Am J Clin Nutr ;95(6)1422-31, 2012
PMID

Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OM, Amin N, Kemp JP, Koller DL, Li G, Liu CT, Minster RL, Moayyeri A, Vandenput L, Willner D, Xiao SM, Yerges-Armstrong LM, Zheng HF, Alonso N, Eriksson J, Kammerer CM, Kaptoge SK, Leo PJ, Thorleifsson G, Wilson SG, Wilson JF, Aalto V, Alen M, Aragaki AK, Aspelund T, Center JR, Dailiana Z, Duggan DJ, Garcia M, Garcia-Giralt N, Giroux S, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Khusainova R, Kim GS, Kooperberg C, Koromila T, Kruk M, Laaksonen M, Lacroix AZ, Lee SH, Leung PC, Lewis JR, Masi L, Mencej-Bedrac S, Nguyen TV, Nogues X, Patel MS, Prezelj J, Rose LM, Scollen S, Siggeirsdottir K, Smith AV, Svensson O, Trompet S, Trummer O, van Schoor NM, Woo J, Zhu K, Balcells S, Brandi ML, Buckley BM, Cheng S, Christiansen C, Cooper C, Dedoussis G, Ford I, Frost M, Goltzman D, González-Macías J, Kähönen M, Karlsson M, Khusnutdinova E, Koh JM, Kollia P, Langdahl BL, Le

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PMID



;
PMID

Nat Genet
44(5)
491-501 ;, 2012
PMID

Koskela J, Kähönen M, Nieminen T, Lehtinen R, Viik J, Nikus K, Niemelä K, Kööbi T, Tobin MD, Samani NJ, Turjanmaa V, Pörsti I, Lehtimäki T
Allelic variant of NOS1AP effects on cardiac alternans of repolarization during exercise testing.
Scand J Clin Lab Invest ;72(2)100-7, 2012
PMID

Laitinen TT, Pahkala K, Magnussen CG, Viikari JS, Oikonen M, Taittonen L, Mikkilä V, Jokinen E, Hutri-Kähönen N, Laitinen T, Kähönen M, Lehtimäki T, Raitakari OT, Juonala M
Ideal cardiovascular health in childhood and cardiometabolic outcomes in adulthood: the Cardiovascular Risk in Young Finns Study.
Circulation ;125(16)1971-8, 2012
PMID

Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna AS, Stancáková A, Barnes C, Widen E, Kajantie E, Eriksson JG, Viikari J, Kähönen M, Lehtimäki T, Raitakari OT, Hartikainen AL, Ruokonen A, Pouta A, Jula A, Kangas AJ, Soininen P, Ala-Korpela M, Männistö S, Jousilahti P, Bonnycastle LL, Järvelin MR, Kuusisto J, Collins FS, Laakso M, Hurles ME, Palotie A, Peltonen L, Ripatti S, Salomaa V
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
Circ Cardiovasc Genet ;5(2)242-9, 2012
PMID

Juonala M, Magnussen CG, Venn A, Gall S, Kähönen M, Laitinen T, Taittonen L, Lehtimäki T, Jokinen E, Sun C, Viikari JS, Dwyer T, Raitakari OT
Parental smoking in childhood and brachial artery flow-mediated dilatation in young adults: the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health study.
Arterioscler Thromb Vasc Biol ;32(4)1024-31, 2012
PMID

Koivistoinen T, Virtanen M, Hutri-Kähönen N, Lehtimäki T, Jula A, Juonala M, Moilanen L, Aatola H, Hyttinen J, Viikari JS, Raitakari OT, Kähönen M
Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey.
Atherosclerosis ;220(2)387-93, 2012
PMID

Kestilä P, Magnussen CG, Viikari JS, Kähönen M, Hutri-Kähönen N, Taittonen L, Jula A, Loo BM, Pietikäinen M, Jokinen E, Lehtimäki T, Kivimäki M, Juonala M, Raitakari OT
Socioeconomic status, cardiovascular risk factors, and subclinical atherosclerosis in young adults: the cardiovascular risk in Young Finns Study.
Arterioscler Thromb Vasc Biol ;32(3)815-21, 2012
PMID

Tukiainen T, Kettunen J, Kangas AJ, Lyytikäinen LP, Soininen P, Sarin AP, Tikkanen E, O'Reilly PF, Savolainen MJ, Kaski K, Pouta A, Jula A, Lehtimäki T, Kähönen M, Viikari J, Taskinen MR, Jauhiainen M, Eriksson JG, Raitakari O, Salomaa V, Järvelin MR, Perola M, Palotie A, Ala-Korpela M, Ripatti S
Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci.
Hum Mol Genet ;21(6)1444-55, 2012
PMID

Jylhävä J, Lyytikäinen LP, Kähönen M, Hutri-Kähönen N, Kettunen J, Viikari J, Raitakari OT, Lehtimäki T, Hurme M
A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.
PLoS One ;7(4)e35426, 2012
PMID

Levula M, Oksala N, Airla N, Zeitlin R, Salenius JP, Järvinen O, Venermo M, Partio T, Saarinen J, Somppi T, Suominen V, Virkkunen J, Hautalahti J, Laaksonen R, Kähönen M, Mennander A, Kytömäki L, Soini JT, Parkkinen J, Pelto-Huikko M, Lehtimäki T
Genes involved in systemic and arterial bed dependent atherosclerosis--Tampere Vascular study.
PLoS One ;7(4)e33787, 2012
PMID

Hernesniemi JA, Seppälä I, Lyytikäinen LP, Mononen N, Oksala N, Hutri-Kähönen N, Juonala M, Taittonen L, Smith EN, Schork NJ, Chen W, Srinivasan SR, Berenson GS, Murray SS, Laitinen T, Jula A, Kettunen J, Ripatti S, Laaksonen R, Viikari J, Kähönen M, Raitakari OT, Lehtimäki T
Genetic profiling using genome-wide significant coronary artery disease risk variants does not improve the prediction of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study, the Bogalusa Heart Study and the Health 2000 Survey--a meta-analysis of three independent studies.
PLoS One ;7(1)e28931, 2012
PMID

Kettunen J, Tukiainen T, Sarin AP, Ortega-Alonso A, Tikkanen E, Lyytikäinen LP, Kangas AJ, Soininen P, Würtz P, Silander K, Dick DM, Rose RJ, Savolainen MJ, Viikari J, Kähönen M, Lehtimäki T, Pietiläinen KH, Inouye M, McCarthy MI, Jula A, Eriksson J, Raitakari OT, Salomaa V, Kaprio J, Järvelin MR, Peltonen L, Perola M, Freimer NB, Ala-Korpela M, Palotie A, Ripatti S
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
Nat Genet ;44(3)269-76, 2012
PMID

Inouye M, Ripatti S, Kettunen J, Lyytikäinen LP, Oksala N, Laurila PP, Kangas AJ, Soininen P, Savolainen MJ, Viikari J, Kähönen M, Perola M, Salomaa V, Raitakari O, Lehtimäki T, Taskinen MR, Järvelin MR, Ala-Korpela M, Palotie A, de Bakker PI
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
PLoS Genet ;8(8)e1002907, 2012
PMID

Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, Mangino M, Onland-Moret NC, Chen B, Eriksson J, Garcia M, Liu YM, Koster A, Lohman K, Lyytikäinen LP, Petersen AK, Prescott J, Stolk L, Vandenput L, Wood AR, Zhuang WV, Ruokonen A, Hartikainen AL, Pouta A, Bandinelli S, Biffar R, Brabant G, Cox DG, Chen Y, Cummings S, Ferrucci L, Gunter MJ, Hankinson SE, Martikainen H, Hofman A, Homuth G, Illig T, Jansson JO, Johnson AD, Karasik D, Karlsson M, Kettunen J, Kiel DP, Kraft P, Liu J, Ljunggren Ö, Lorentzon M, Maggio M, Markus MR, Mellström D, Miljkovic I, Mirel D, Nelson S, Morin Papunen L, Peeters PH, Prokopenko I, Raffel L, Reincke M, Reiner AP, Rexrode K, Rivadeneira F, Schwartz SM, Siscovick D, Soranzo N, Stöckl D, Tworoger S, Uitterlinden AG, van Gils CH, Vasan RS, Wichmann HE, Zhai G, Bhasin S, Bidlingmaier M, Chanock SJ, De Vivo I, Harris TB, Hunter DJ, Kähönen M, Liu S, Ouyang P, Specto

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PMID

PLoS Genet
8(7)
e1002805 ;, 2012
PMID

2011

Oikonen M, Tikkanen E, Juhola J, Tuovinen T, Seppälä I, Juonala M, Taittonen L, Mikkilä V, Kähönen M, Ripatti S, Viikari J, Lehtimäki T, Havulinna AS, Kee F, Newton-Cheh C, Peltonen L, Schork NJ, Murray SS, Berenson GS, Chen W, Srinivasan SR, Salomaa V, Raitakari OT
Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study.
Hypertension ;58(6)1079-85, 2011
PMID

Tikkanen E, Tuovinen T, Widén E, Lehtimäki T, Viikari J, Kähönen M, Peltonen L, Raitakari OT, Ripatti S
Association of known loci with lipid levels among children and prediction of dyslipidemia in adults.
Circ Cardiovasc Genet ;4(6)673-80, 2011
PMID

Skilton MR, Viikari JS, Juonala M, Laitinen T, Lehtimäki T, Taittonen L, Kähönen M, Celermajer DS, Raitakari OT
Fetal growth and preterm birth influence cardiovascular risk factors and arterial health in young adults: the Cardiovascular Risk in Young Finns Study.
Arterioscler Thromb Vasc Biol ;31(12)2975-81, 2011
PMID

Conde L, Bevan S, Sitzer M, Klopp N, Illig T, Thiery J, Seissler J, Baumert J, Raitakari O, Kähönen M, Lyytikäinen LP, Laaksonen R, Viikari J, Lehtimäki T, Koernig W, Halperin E, Markus HS
Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling.
Atherosclerosis ;219(2)684-9, 2011
PMID

Koivistoinen T, Kööbi T, Moilanen L, Jula A, Lehtimäki T, Hyttinen J, Kähönen M
Arterial tension time reflects subclinical atherosclerosis, arterial stiffness and stroke volume.
Clin Physiol Funct Imaging ;31(6)464-71, 2011
PMID

Vuohelainen V, Raitoharju E, Levula M, Lehtimaki T, Pelto-Huikko M, Honkanen T, Huovila A, Paavonen T, Tarkka M, Mennander A
Myocardial infarction induces early increased remote ADAM8 expression of rat hearts after cardiac arrest.
Scand J Clin Lab Invest ;71(7)553-62, 2011
PMID

Leppänen JM, Peltola MJ, Puura K, Mäntymaa M, Mononen N, Lehtimäki T
Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants.
J Child Psychol Psychiatry ;52(11)1144-52, 2011
PMID

Levula M, Paavonen T, Valo T, Pelto-Huikko M, Laaksonen R, Kahonen M, Huovila A, Lehtimaki T, Tarkka M, Mennander AA
A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection.
Scand J Clin Lab Invest ;71(6)515-22, 2011
PMID

Elovainio M, Hurme M, Jokela M, Pulkki-Råback L, Kivimäki M, Hintsanen M, Hintsa T, Lehtimäki T, Viikari J, Raitakari OT, Keltikangas-Järvinen L
Moderating effect of indoleamine 2,3-dioxygenase (IDO) activation in the association between depressive symptoms and carotid atherosclerosis: evidence from the Young Finns study.
J Affect Disord ;133(3)611-4, 2011
PMID

Juhola J, Magnussen CG, Viikari JS, Kähönen M, Hutri-Kähönen N, Jula A, Lehtimäki T, Åkerblom HK, Pietikäinen M, Laitinen T, Jokinen E, Taittonen L, Raitakari OT, Juonala M
Tracking of serum lipid levels, blood pressure, and body mass index from childhood to adulthood: the Cardiovascular Risk in Young Finns Study.
J Pediatr ;159(4)584-90, 2011
PMID

Anttila I, Nikus K, Nieminen T, Jula A, Salomaa V, Reunanen A, Nieminen MS, Lehtimäki T, Virtanen V, Kähönen M
Relation of positive T wave in lead aVR to risk of cardiovascular mortality.
Am J Cardiol ;108(12)1735-40, 2011
PMID

Turpeinen H, Raitoharju E, Oksanen A, Oksala N, Levula M, Lyytikäinen LP, Järvinen O, Creemers JW, Kähönen M, Laaksonen R, Pelto-Huikko M, Lehtimäki T, Pesu M
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.
Atherosclerosis ;219(2)799-806, 2011
PMID

Lindroos MM, Borra R, Mononen N, Lehtimäki T, Virtanen KA, Lepomäki V, Guiducci L, Iozzo P, Majamaa K, Nuutila P
Mitochondrial diabetes is associated with insulin resistance in subcutaneous adipose tissue but not with increased liver fat content.
J Inherit Metab Dis ;34(6)1205-12, 2011
PMID

Juonala M, Juhola J, Magnussen CG, Würtz P, Viikari JS, Thomson R, Seppälä I, Hernesniemi J, Kähönen M, Lehtimäki T, Hurme M, Telama R, Mikkilä V, Eklund C, Räsänen L, Hintsanen M, Keltikangas-Järvinen L, Kivimäki M, Raitakari OT
Childhood environmental and genetic predictors of adulthood obesity: the cardiovascular risk in young Finns study.
J Clin Endocrinol Metab ;96(9)E1542-9, 2011
PMID

Kettunen T, Eklund C, Kähönen M, Jula A, Päivä H, Lyytikäinen LP, Hurme M, Lehtimäki T
Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey.
Scand J Clin Lab Invest ;71(5)353-61, 2011
PMID

Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, Ahmad T, Mora S, Kaakinen M, Sandholt CH, Holzapfel C, Autenrieth CS, Hyppönen E, Cauchi S, He M, Kutalik Z, Kumari M, Stančáková A, Meidtner K, Balkau B, Tan JT, Mangino M, Timpson NJ, Song Y, Zillikens MC, Jablonski KA, Garcia ME, Johansson S, Bragg-Gresham JL, Wu Y, van Vliet-Ostaptchouk JV, Onland-Moret NC, Zimmermann E, Rivera NV, Tanaka T, Stringham HM, Silbernagel G, Kanoni S, Feitosa MF, Snitker S, Ruiz JR, Metter J, Larrad MT, Atalay M, Hakanen M, Amin N, Cavalcanti-Proença C, Grøntved A, Hallmans G, Jansson JO, Kuusisto J, Kähönen M, Lutsey PL, Nolan JJ, Palla L, Pedersen O, Pérusse L, Renström F, Scott RA, Shungin D, Sovio U, Tammelin TH, Rönnemaa T, Lakka TA, Uusitupa M, Rios MS, Ferrucci L, Bouchard C, Meirhaeghe A, Fu M, Walker M, Borecki IB, Dedoussis GV, Fritsche A, Ohlsson C, Boehnke M, Bandinelli S, van Duijn CM, Ebrahim S, Lawlor DA, Gudnason V, Harris

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PMID

PLoS Med
8(11)
e1001116 ;, 2011
PMID

Raitoharju E, Lyytikäinen LP, Levula M, Oksala N, Mennander A, Tarkka M, Klopp N, Illig T, Kähönen M, Karhunen PJ, Laaksonen R, Lehtimäki T
miR-21, miR-210, miR-34a, and miR-146a/b are up-regulated in human atherosclerotic plaques in the Tampere Vascular Study.
Atherosclerosis ;219(1)211-7, 2011
PMID

Juonala M, Saarikoski LA, Viikari JS, Oikonen M, Lehtimäki T, Lyytikäinen LP, Huupponen R, Magnussen CG, Koskinen J, Laitinen T, Taittonen L, Kähönen M, Kivimäki M, Raitakari OT
A longitudinal analysis on associations of adiponectin levels with metabolic syndrome and carotid artery intima-media thickness. The Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;217(1)234-9, 2011
PMID

Raitoharju E, Seppälä I, Levula M, Kuukasjärvi P, Laurikka J, Nikus K, Huovila AP, Oksala N, Klopp N, Illig T, Laaksonen R, Karhunen PJ, Viik J, Lehtinen R, Pelto-Huikko M, Tarkka M, Kähönen M, Lehtimäki T
Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts.
Atherosclerosis ;218(1)127-33, 2011
PMID

Haarala A, Kähönen M, Eklund C, Jylhävä J, Koskinen T, Taittonen L, Huupponen R, Lehtimäki T, Viikari J, Raitakari OT, Hurme M
Heart rate variability is independently associated with C-reactive protein but not with Serum amyloid A. The Cardiovascular Risk in Young Finns Study.
Eur J Clin Invest ;41(9)951-7, 2011
PMID

Viikki M, Huuhka K, Leinonen E, Illi A, Setälä-Soikkeli E, Huuhka M, Mononen N, Lehtimäki T, Kampman O
Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD.
Neurosci Lett ;501(1)20-4, 2011
PMID

Komurcu-Bayrak E, Onat A, Yuzbasiogullari B, Mononen N, Laaksonen R, Kähönen M, Hergenc G, Lehtimäki T, Erginel-Unaltuna N
The APOE -219G/T and +113G/C polymorphisms affect insulin resistance among Turks.
Metabolism ;60(5)655-63, 2011
PMID

Koivistoinen T, Jula A, Aatola H, Kööbi T, Moilanen L, Lehtimäki T, Kähönen M
Systemic hemodynamics in relation to glucose tolerance: the Health 2000 Survey.
Metabolism ;60(4)557-63, 2011
PMID

Koivistoinen T, Hutri-Kähönen N, Juonala M, Aatola H, Kööbi T, Lehtimäki T, Viikari JS, Raitakari OT, Kähönen M
Metabolic syndrome in childhood and increased arterial stiffness in adulthood: the Cardiovascular Risk In Young Finns Study.
Ann Med ;43(4)312-9, 2011
PMID

Solakivi T, Kaukinen K, Kunnas T, Lehtimäki T, Mäki M, Nikkari ST
Serum fatty acid profile in subjects with irritable bowel syndrome.
Scand J Gastroenterol ;46(3)299-303, 2011
PMID

Tolonen S, Mikkilä V, Laaksonen M, Sievänen H, Mononen N, Hernesniemi J, Vehkalahti K, Viikari J, Raitakari O, Kähönen M, Lehtimäki T
Association of apolipoprotein E promoter polymorphisms with bone structural traits is modified by dietary saturated fat intake - the Cardiovascular Risk in Young Finns study.
Bone ;48(5)1058-65, 2011
PMID

Kenttä T, Karsikas M, Junttila MJ, Perkiömäki JS, Seppänen T, Kiviniemi A, Nieminen T, Lehtimäki T, Nikus K, Lehtinen R, Viik J, Kähönen M, Huikuri HV
QRS-T morphology measured from exercise electrocardiogram as a predictor of cardiac mortality.
Europace ;13(5)701-7, 2011
PMID

Viikki M, Kampman O, Anttila S, Illi A, Setälä-Soikkeli E, Huuhka M, Mononen N, Lehtimäki T, Leinonen E
P2RX7 polymorphisms Gln460Arg and His155Tyr are not associated with major depressive disorder or remission after SSRI or ECT.
Neurosci Lett ;493(3)127-30, 2011
PMID

Kivimäki M, Magnussen CG, Juonala M, Kähönen M, Kettunen J, Loo BM, Lehtimäki T, Viikari J, Raitakari OT
Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the Young Finns Study.
Int J Epidemiol ;40(2)470-8, 2011
PMID

Liu M, Rogers L, Cheng Q, Shao Y, Fernandez-Beros ME, Hirschhorn JN, Lyon HN, Gajdos ZK, Vedantam S, Gregersen P, Seldin MF, Bleck B, Ramasamy A, Hartikainen AL, Jarvelin MR, Kuokkanen M, Laitinen T, Eriksson J, Lehtimäki T, Raitakari OT, Reibman J
Genetic variants of TSLP and asthma in an admixed urban population.
PLoS One ;6(9)e25099, 2011
PMID

Hannukainen JC, Borra R, Linderborg K, Kallio H, Kiss J, Lepomäki V, Kalliokoski KK, Kujala UM, Kaprio J, Heinonen OJ, Komu M, Parkkola R, Ahotupa M, Lehtimäki T, Huupponen R, Iozzo P, Nuutila P
Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity.
J Hepatol ;54(3)545-52, 2011
PMID

Leino J, Verrier RL, Minkkinen M, Lehtimäki T, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M, Nieminen T
Importance of regional specificity of T-wave alternans in assessing risk for cardiovascular mortality and sudden cardiac death during routine exercise testing.
Heart Rhythm ;8(3)385-90, 2011
PMID

Illi A, Poutanen O, Setälä-Soikkeli E, Kampman O, Viikki M, Huhtala H, Mononen N, Haraldsson S, Koivisto PA, Leinonen E, Lehtimäki T
Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD?
Eur Arch Psychiatry Clin Neurosci ;261(2)95-102, 2011
PMID

Würtz P, Soininen P, Kangas AJ, Mäkinen VP, Groop PH, Savolainen MJ, Juonala M, Viikari JS, Kähönen M, Lehtimäki T, Raitakari OT, Ala-Korpela M
Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis.
Mol Biosyst ;7(2)385-93, 2011
PMID

Koivistoinen T, Hutri-Kähönen N, Juonala M, Kööbi T, Aatola H, Lehtimäki T, Viikari JS, Raitakari OT, Kähönen M
Apolipoprotein B is related to arterial pulse wave velocity in young adults: the Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;214(1)220-4, 2011
PMID

2010

Andre K, Kampman O, Setälä-Soikkeli E, Viikki M, Poutanen O, Nuolivirta T, Mononen N, Lehtimäki T, Leinonen E, Illi A
Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.
J Neural Transm (Vienna) ;117(12)1431-4, 2010
PMID

Aatola H, Koivistoinen T, Hutri-Kähönen N, Juonala M, Mikkilä V, Lehtimäki T, Viikari JS, Raitakari OT, Kähönen M
Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the Cardiovascular Risk in Young Finns Study.
Circulation ;122(24)2521-8, 2010
PMID

Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, Kähönen M, Mayosi BM, Jula A, Moilanen L, Willeit J, Watkins H, Samani NJ, Lehtimäki TJ, Keavney B, Xu Q, Ye S
Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.
Arterioscler Thromb Vasc Biol ;30(12)2678-83, 2010
PMID

Koivistoinen T, Aatola H, Hutri-Kähönen N, Juonala M, Viikari JS, Laitinen T, Taittonen L, Lehtimäki T, Kööbi T, Raitakari OT, Kähönen M
Systemic hemodynamics in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study.
Ann Med ;42(8)612-21, 2010
PMID

Salo J, Pulkki-Råback L, Hintsanen M, Lehtimäki T, Keltikangas-Järvinen L
The interaction between serotonin receptor 2A and catechol-O-methyltransferase gene polymorphisms is associated with the novelty-seeking subscale impulsiveness.
Psychiatr Genet ;20(6)273-81, 2010
PMID

Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, Ferreira T, Wood AR, Weyant RJ, Segrè AV, Speliotes EK, Wheeler E, Soranzo N, Park JH, Yang J, Gudbjartsson D, Heard-Costa NL, Randall JC, Qi L, Vernon Smith A, Mägi R, Pastinen T, Liang L, Heid IM, Luan J, Thorleifsson G, Winkler TW, Goddard ME, Sin Lo K, Palmer C, Workalemahu T, Aulchenko YS, Johansson A, Zillikens MC, Feitosa MF, Esko T, Johnson T, Ketkar S, Kraft P, Mangino M, Prokopenko I, Absher D, Albrecht E, Ernst F, Glazer NL, Hayward C, Hottenga JJ, Jacobs KB, Knowles JW, Kutalik Z, Monda KL, Polasek O, Preuss M, Rayner NW, Robertson NR, Steinthorsdottir V, Tyrer JP, Voight BF, Wiklund F, Xu J, Zhao JH, Nyholt DR, Pellikka N, Perola M, Perry JR, Surakka I, Tammesoo ML, Altmaier EL, Amin N, Aspelund T, Bhangale T, Boucher G, Chasman DI, Chen C, Coin L, Cooper MN, Dixon AL, Gibson Q, Grundberg E, Hao K, Juhani Junttila

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PMID



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PMID



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PMID

Nature
467(7317)
832-8 ;, 2010
PMID

Raiko JR, Magnussen CG, Kivimäki M, Taittonen L, Laitinen T, Kähönen M, Hutri-Kähönen N, Jula A, Loo BM, Thomson RJ, Lehtimäki T, Viikari JS, Raitakari OT, Juonala M
Cardiovascular risk scores in the prediction of subclinical atherosclerosis in young adults: evidence from the cardiovascular risk in a young Finns study.
Eur J Cardiovasc Prev Rehabil ;17(5)549-55, 2010
PMID

Ozsait B, Komurcu-Bayrak E, Levula M, Erginel-Unaltuna N, Kähönen M, Rai M, Lehtimäki T, Laaksonen R
Niemann-Pick type C fibroblasts have a distinct microRNA profile related to lipid metabolism and certain cellular components.
Biochem Biophys Res Commun ;403(3-4)316-21, 2010
PMID

Smith EN, Chen W, Kähönen M, Kettunen J, Lehtimäki T, Peltonen L, Raitakari OT, Salem RM, Schork NJ, Shaw M, Srinivasan SR, Topol EJ, Viikari JS, Berenson GS, Murray SS
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
PLoS Genet ;6(9)e1001094, 2010
PMID

Hernesniemi JA, Anttila K, Nieminen T, Kähönen M, Mononen N, Nikus K, Turjanmaa V, Viik J, Lehtinen R, Lehtimäki T
IL-18 gene polymorphism, cardiovascular mortality and coronary artery disease.
Eur J Clin Invest ;40(11)994-1001, 2010
PMID

Anttila I, Nikus K, Kähönen M, Jula A, Reunanen A, Salomaa V, Nieminen MS, Lehtimäki T, Virtanen V, Verrier RL, Varis J, Sclarovsky S, Nieminen T
Prognostic implications of quantitative ST-segment characteristics and T-wave amplitude for cardiovascular mortality in a general population from the Health 2000 Survey.
Ann Med ;42(7)502-11, 2010
PMID

Päivä H, Kähönen M, Lehtimäki T, Alfthan G, Viikari J, Laaksonen R, Hutri-Kähönen N, Laitinen T, Taittonen L, Raitakari OT, Juonala M
Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;212(2)512-5, 2010
PMID

Oksala N, Levula M, Pelto-Huikko M, Kytömäki L, Soini JT, Salenius J, Kähönen M, Karhunen PJ, Laaksonen R, Parkkila S, Lehtimäki T
Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study.
Ann Med ;42(5)360-70, 2010
PMID

Kiviniemi TO, Saraste A, Lehtimäki T, Toikka JO, Saraste M, Raitakari OT, Hartiala JJ, Viikari J, Koskenvuo JW
Decreased endothelin-1 levels after acute consumption of red wine and de-alcoholized red wine.
Atherosclerosis ;211(1)283-6, 2010
PMID

Okser S, Lehtimäki T, Elo LL, Mononen N, Peltonen N, Kähönen M, Juonala M, Fan YM, Hernesniemi JA, Laitinen T, Lyytikäinen LP, Rontu R, Eklund C, Hutri-Kähönen N, Taittonen L, Hurme M, Viikari JS, Raitakari OT, Aittokallio T
Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study.
PLoS Genet ;6(9)e1001146, 2010
PMID

Leino J, Virtanen M, Kähönen M, Nikus K, Lehtimäki T, Kööbi T, Lehtinen R, Turjanmaa V, Viik J, Nieminen T
Exercise-test-related heart rate variability and mortality: the Finnish Cardiovascular Study.
Int J Cardiol ;144(1)154-5, 2010
PMID

Viikki M, Anttila S, Kampman O, Illi A, Huuhka M, Setälä-Soikkeli E, Mononen N, Lehtimäki T, Leinonen E
Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment resistant depression.
Neurosci Lett ;477(3)105-8, 2010
PMID

Widén E, Ripatti S, Cousminer DL, Surakka I, Lappalainen T, Järvelin MR, Eriksson JG, Raitakari O, Salomaa V, Sovio U, Hartikainen AL, Pouta A, McCarthy MI, Osmond C, Kajantie E, Lehtimäki T, Viikari J, Kähönen M, Tyler-Smith C, Freimer N, Hirschhorn JN, Peltonen L, Palotie A
Distinct variants at LIN28B influence growth in height from birth to adulthood.
Am J Hum Genet ;86(5)773-82, 2010
PMID

Skilton MR, Bonnet F, Begg LM, Juonala M, Kähönen M, Lehtimäki T, Viikari JS, Raitakari OT
Childbearing, child-rearing, cardiovascular risk factors, and progression of carotid intima-media thickness: the Cardiovascular Risk in Young Finns study.
Stroke ;41(7)1332-7, 2010
PMID

Juonala M, Viikari JS, Kähönen M, Taittonen L, Laitinen T, Hutri-Kähönen N, Lehtimäki T, Jula A, Pietikäinen M, Jokinen E, Telama R, Räsänen L, Mikkilä V, Helenius H, Kivimäki M, Raitakari OT
Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study.
Eur Heart J ;31(14)1745-51, 2010
PMID

Puurtinen M, Nieminen T, Kähönen M, Lehtimäki T, Lehtinen R, Nikus K, Hyttinen J, Viik J
Value of leads V4R and CM5 in the detection of coronary artery disease during exercise electrocardiographic test.
Clin Physiol Funct Imaging ;30(4)308-12, 2010
PMID

Hernesniemi JA, Heikkilä A, Raitakari OT, Kähönen M, Juonala M, Hutri-Kähönen N, Marniemi J, Viikari J, Lehtimäki T
Interleukin-18 gene polymorphism and markers of subclinical atherosclerosis. The Cardiovascular Risk in Young Finns Study.
Ann Med ;42(3)223-30, 2010
PMID

Svart K, Lehtinen R, Nieminen T, Nikus K, Lehtimäki T, Kööbi T, Niemelä K, Niemi M, Turjanmaa V, Kähönen M, Viik J
Exercise electrocardiography detection of coronary artery disease by ST-segment depression/heart rate hysteresis in women: the Finnish Cardiovascular Study.
Int J Cardiol ;140(2)182-8, 2010
PMID

Nieminen T, Verrier RL, Leino J, Nikus K, Lehtinen R, Lehtimäki T, Minkkinen M, Kööbi T, Turjanmaa V, Viik J, Kähönen M
Atrioventricular conduction and cardiovascular mortality: assessment of recovery PR interval is superior to pre-exercise measurement.
Heart Rhythm ;7(6)796-801, 2010
PMID

Anttila I, Nikus K, Nieminen T, Jula A, Reunanen A, Salomaa V, Kattainen A, Nieminen MS, Lehtimäki T, Virtanen V, Sclarovsky S, Kähönen M
Prevalence and prognostic value of poor R-wave progression in standard resting electrocardiogram in a general adult population. The Health 2000 Survey.
Ann Med ;42(2)123-30, 2010
PMID

Aatola H, Hutri-Kähönen N, Juonala M, Viikari JS, Hulkkonen J, Laitinen T, Taittonen L, Lehtimäki T, Raitakari OT, Kähönen M
Lifetime risk factors and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study.
Hypertension ;55(3)806-11, 2010
PMID

Niinisalo P, Oksala N, Levula M, Pelto-Huikko M, Järvinen O, Salenius JP, Kytömäki L, Soini JT, Kähönen M, Laaksonen R, Hurme M, Lehtimäki T
Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study.
Ann Med ;42(1)55-63, 2010
PMID

Heiskanen M, Kähönen M, Hurme M, Lehtimäki T, Mononen N, Juonala M, Hutri-Kähönen N, Viikari J, Raitakari O, Hulkkonen J
Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;208(1)190-6, 2010
PMID

Illi A, Setälä-Soikkeli E, Kampman O, Viikki M, Nuolivirta T, Poutanen O, Huhtala H, Mononen N, Lehtimäki T, Leinonen E
Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder.
Psychiatry Res ;176(1)85-7, 2010
PMID

Kettunen J, Silander K, Saarela O, Amin N, Müller M, Timpson N, Surakka I, Ripatti S, Laitinen J, Hartikainen AL, Pouta A, Lahermo P, Anttila V, Männistö S, Jula A, Virtamo J, Salomaa V, Lehtimäki T, Raitakari O, Gieger C, Wichmann EH, Van Duijn CM, Smith GD, McCarthy MI, Järvelin MR, Perola M, Peltonen L
European lactase persistence genotype shows evidence of association with increase in body mass index.
Hum Mol Genet ;19(6)1129-36, 2010
PMID

Viikki M, Kampman O, Illi A, Setälä-Soikkeli E, Anttila S, Huuhka M, Nuolivirta T, Poutanen O, Mononen N, Lehtimäki T, Leinonen E
TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response.
Neurosci Lett ;468(1)80-4, 2010
PMID

2009

2008

Viiri LE, Viiri KM, Ilveskoski E, Huhtala H, Mäki M, Tienari PJ, Perola M, Lehtimäki T, Karhunen PJ
Interactions of functional apolipoprotein E gene promoter polymorphisms with smoking on aortic atherosclerosis.
Circ Cardiovasc Genet ;1(2)107-16, 2008
PMID

Fan YM, Karhunen PJ, Levula M, Ilveskoski E, Mikkelsson J, Kajander OA, Järvinen O, Oksala N, Thusberg J, Vihinen M, Salenius JP, Kytömäki L, Soini JT, Laaksonen R, Lehtimäki T
Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.
Thromb J ;2008
PMID

Rinta S, Kuusisto H, Raunio M, Paalavuo R, Levula M, Lehtimäki T, Elovaara I
Apoptosis-related molecules in blood in multiple sclerosis.
J Neuroimmunol ;205(1-2)135-41, 2008
PMID

Nikkari ST, Henttonen A, Kunnas T, Kähönen M, Hutri-Kähönen N, Juonala M, Marniemi J, Viikari J, Raitakari OT, Lehtimäki T
Estrogen receptor 2 polymorphism and carotid intima-media thickness.
Genet Test ;12(4)537-40, 2008
PMID

Huuhka K, Anttila S, Huuhka M, Hietala J, Huhtala H, Mononen N, Lehtimäki T, Leinonen E
Dopamine 2 receptor C957T and catechol-o-methyltransferase Val158Met polymorphisms are associated with treatment response in electroconvulsive therapy.
Neurosci Lett ;448(1)79-83, 2008
PMID

Salminen M, Lehtimäki T, Fan YM, Vahlberg T, Kivelä SL
Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene and changes in serum lipids during a family-based counselling intervention among school-aged children with a family history of CVD.
Public Health Nutr ;11(11)1156-62, 2008
PMID

Nieminen T, Kähönen M, Viiri LE, Grönroos P, Lehtimäki T
Pharmacogenetics of apolipoprotein E gene during lipid-lowering therapy: lipid levels and prevention of coronary heart disease.
Pharmacogenomics ;9(10)1475-86, 2008
PMID

Raitakari OT, Juonala M, Rönnemaa T, Keltikangas-Järvinen L, Räsänen L, Pietikäinen M, Hutri-Kähönen N, Taittonen L, Jokinen E, Marniemi J, Jula A, Telama R, Kähönen M, Lehtimäki T, Akerblom HK, Viikari JS
Cohort profile: the cardiovascular risk in Young Finns Study.
Int J Epidemiol ;37(6)1220-6, 2008
PMID

Service HM, Hintsanen M, Hintsa T, Lehtimäki T, Raitakari OT, Viikari JS, Keltikangas-Järvinen L
Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study.
Behav Brain Funct ;2008
PMID

Lehtimäki T, Hutri-Kähönen N, Kähönen M, Hemminki J, Mikkilä V, Laaksonen M, Räsänen L, Mononen N, Juonala M, Marniemi J, Viikari J, Raitakari O
Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study.
Clin Sci (Lond) ;115(9)265-71, 2008
PMID

Koskela J, Kähönen M, Fan M, Nieminen T, Lehtinen R, Viik J, Nikus K, Niemelä K, Kööbi T, Turjanmaa V, Pörsti I, Lehtimäki T
Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study.
Transl Res ;152(2)49-58, 2008
PMID

Päivä H, Kähönen M, Lehtimäki T, Raitakari OT, Jula A, Viikari J, Alfthan G, Juonala M, Laaksonen R, Hutri-Kähönen N
Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.
Am J Hypertens ;21(8)873-8, 2008
PMID

Ilveskoski E, Viiri LE, Mikkelsson J, Pörsti I, Lehtimäki T, Karhunen PJ
Neuropeptide Y signal peptide Pro7 substitution protects against coronary artery atherosclerosis: the Helsinki Sudden Death Study.
Atherosclerosis ;199(2)445-50, 2008
PMID

Kivimäki M, Smith GD, Timpson NJ, Lawlor DA, Batty GD, Kähönen M, Juonala M, Rönnemaa T, Viikari JS, Lehtimäki T, Raitakari OT
Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study.
Eur Heart J ;29(20)2552-60, 2008
PMID

Tobin MD, Kähönen M, Braund P, Nieminen T, Hajat C, Tomaszewski M, Viik J, Lehtinen R, Ng GA, Macfarlane PW, Burton PR, Lehtimäki T, Samani NJ
Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.
Int J Epidemiol ;37(5)1132-41, 2008
PMID

Collings A, Höyssä S, Fan M, Kähönen M, Hutri-Kähönen N, Marniemi J, Juonala M, Viikari JS, Raitakari OT, Lehtimäki TJ
Allelic variants of upstream transcription factor 1 associate with carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns study.
Circ J ;72(7)1158-64, 2008
PMID

Samani NJ, Raitakari OT, Sipilä K, Tobin MD, Schunkert H, Juonala M, Braund PS, Erdmann J, Viikari J, Moilanen L, Taittonen L, Jula A, Jokinen E, Laitinen T, Hutri-Kähönen N, Nieminen MS, Kesäniemi YA, Hall AS, Hulkkonen J, Kähönen M, Lehtimäki T
Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis.
Arterioscler Thromb Vasc Biol ;28(9)1679-83, 2008
PMID

Miettinen TA, Gylling H, Viikari J, Lehtimäki T, Raitakari OT
Synthesis and absorption of cholesterol in Finnish boys by serum non-cholesterol sterols: the cardiovascular risk in Young Finns Study.
Atherosclerosis ;200(1)177-83, 2008
PMID

Hintsanen M, Elovainio M, Puttonen S, Kivimäki M, Lehtimäki T, Kähönen M, Juonala M, Rontu R, Viikari JS, Raitakari OT, Keltikangas-Järvinen L
Val/Met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men.
J Occup Environ Med ;50(6)649-57, 2008
PMID

Lee JC, Weissglas-Volkov D, Kyttälä M, Dastani Z, Cantor RM, Sobel EM, Plaisier CL, Engert JC, van Greevenbroek MM, Kane JP, Malloy MJ, Pullinger CR, Huertas-Vazquez A, Aguilar-Salinas CA, Tusie-Luna T, de Bruin TW, Aouizerat BE, van der Kallen CC, Croce CM, Aqeilan RI, Marcil M, Viikari JS, Lehtimäki T, Raitakari OT, Kuusisto J, Laakso M, Taskinen MR, Genest J, Pajukanta P
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
Am J Hum Genet ;83(2)180-92, 2008
PMID

Abboud S, Viiri LE, Lütjohann D, Goebeler S, Luoto T, Friedrichs S, Desfontaines P, Gazagnes MD, Laloux P, Peeters A, Seeldrayers P, Lehtimaki T, Karhunen P, Pandolfo M, Laaksonen R
Associations of apolipoprotein E gene with ischemic stroke and intracranial atherosclerosis.
Eur J Hum Genet ;16(8)955-60, 2008
PMID

Mäkelä R, Loimaala A, Nenonen A, Mercuri M, Vuori I, Huhtala H, Oja P, Bond G, Koivula T, Lehtimäki T
The association of myeloperoxidase promoter polymorphism with carotid atherosclerosis is abolished in patients with type 2 diabetes.
Clin Biochem ;41(7-8)532-7, 2008
PMID

Hernesniemi JA, Raitakari OT, Kähönen M, Juonala M, Hutri-Kähönen N, Marniemi J, Viikari J, Lehtimäki T
Toll-like receptor 4 gene (Asp299Gly) polymorphism associates with carotid artery elasticity. The cardiovascular risk in young Finns study.
Atherosclerosis ;198(1)152-9, 2008
PMID

Anttila S, Huuhka K, Huuhka M, Illi A, Rontu R, Leinonen E, Lehtimäki T
Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy.
Pharmacogenomics J ;8(2)113-6, 2008
PMID

Kiviniemi TO, Saraste A, Toikka JO, Saraste M, Raitakari OT, Pärkkä JP, Lehtimäki T, Hartiala JJ, Viikari J, Koskenvuo JW
Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men.
Cardiovasc Ultrasound ;2008
PMID

Huuhka K, Kampman O, Anttila S, Huuhka M, Rontu R, Mattila KM, Hurme M, Lehtimäki T, Leinonen E
RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder.
Neurosci Lett ;437(1)25-8, 2008
PMID

Kristiansson K, Ilveskoski E, Lehtimäki T, Peltonen L, Perola M, Karhunen PJ
Association analysis of allelic variants of USF1 in coronary atherosclerosis.
Arterioscler Thromb Vasc Biol ;28(5)983-9, 2008
PMID

Siirtola A, Virtanen SM, Ala-Houhala M, Koivisto AM, Solakivi T, Lehtimäki T, Holmberg C, Antikainen M, Salo MK
Diet does not explain the high prevalence of dyslipidaemia in paediatric renal transplant recipients.
Pediatr Nephrol ;23(2)297-305, 2008
PMID

Hernesniemi JA, Karhunen PJ, Rontu R, Ilveskoski E, Kajander O, Goebeler S, Viiri LE, Pessi T, Hurme M, Lehtimäki T
Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study.
Atherosclerosis ;196(2)643-9, 2008
PMID

Elovainio M, Puttonen S, Pulkki-Råback L, Kivimaki M, Viiri LE, Lehtimaki T, Karhunen P, Viikari J, Raitakari OT, Keltikangas-Jarvinen L
Association of the apolipoprotein E gene, its promoter polymorphisms and haplotypes with depressive symptoms. The Cardiovascular Risk in Young Finns Study.
Neuropsychobiology ;58(2)91-6, 2008
PMID

Mennander A, Kuukasjärvi P, Laurikka J, Nikus K, Karhunen PJ, Tarkka M, Lehtimäki T
Diagnostic performance of plasma high sensitive C-reactive protein in detecting three-vessel coronary artery disease: modification by apolipoprotein E genotype.
Scand J Clin Lab Invest ;68(8)714-9, 2008
PMID

Collings A, Raitakari OT, Juonala M, Mansikkaniemi K, Kähönen M, Hutri-Kähönen N, Marniemi J, Viikari JS, Lehtimäki TJ
The influence of smoking and homocysteine on subclinical atherosclerosis is modified by the connexin37 C1019T polymorphism - The Cardiovascular Risk in Young Finns Study.
Clin Chem Lab Med ;46(8)1102-8, 2008
PMID

Grönroos P, Raitakari OT, Kähönen M, Hutri-Kähönen N, Juonala M, Marniemi J, Viikari J, Lehtimäki T
Relation of apolipoprotein E polymorphism to markers of early atherosclerotic changes in young adults--the Cardiovascular Risk in Young Finns Study.
Circ J ;72(1)29-34, 2008
PMID

Hänninen K, Katila H, Saarela M, Rontu R, Mattila KM, Fan M, Hurme M, Lehtimäki T
Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia.
Eur Arch Psychiatry Clin Neurosci ;258(1)10-5, 2008
PMID

Karstila K, Harmoinen AP, Lehtimäki TJ, Korpela MM, Mustonen JT, Saha HH
Measurement of the kidney function in patients with rheumatoid arthritis: plasma cystatin C versus 51Cr-EDTA clearance.
Nephron Clin Pract ;108(4)c284-90, 2008
PMID

Grönroos P, Raitakari OT, Kähönen M, Hutri-Kähönen N, Marniemi J, Viikari J, Lehtimäki T
Association of high sensitive C-reactive protein with apolipoprotein E polymorphism in children and young adults: the Cardiovascular Risk in Young Finns Study.
Clin Chem Lab Med ;46(2)179-86, 2008
PMID

2007

2006

2005

2004

2003

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1999

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1995

1994

1993

1992

1991