Bal-Price Anna, Hogberg Helena T, Crofton Kevin M,  Danieshan Mardas, FrizGerald Rex E, Crofton Kevin M, Fritsche Ellen, Heinonen Tuula, Hougaard Bennekou Susanne, Klima Stefanie, Piersma Aldert H, Sachana Magdaliini, Shaefer Timothy J, Terron Andrea, Monnet-Tschudi Florianne, Viviani Barbara, Waldmann Tanja, Westerink Remco H.S., Wilks Martin F., Witters Hilda, Zurich Marie-Gabrielle and Leist Marcel. t4 Workshop Report. Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX preprint published February 23, 2018, version 2.

Sharon Buring Stuard and Tuula Heinonen. Relevance and Application of Read‐Across – Mini Review of European Consensus Platform for Alternatives and Scandinavian Society for Cell Toxicology 2017 Workshop Session. Basic Clin Pharmacol Toxicol. 2018. https://doi.org/10.1111/bcpt.13006

Huttala O, Palmroth M, Hemminki P, Toimela T, Heinonen T, Ylikomi T, Sarkanen JR. Development of Versatile Human In Vitro Vascularized Adipose Tissue Model with Serum-Free Angiogenesis and Natural Adipogenesis Induction. Basic Clin Pharmacol Toxicol. 2018 Feb 14. doi: 10.1111/bcpt.12987. [Epub ahead of print]

Mannerström M, Toimela T, Sarkanen JR, Heinonen T 2017: Human BJ Fibroblasts is an Alternative to Mouse BALB/c 3T3 Cells in In Vitro Neutral Red Uptake Assay. Basic Clin Pharmacol Toxicol. 2017 Apr 4. doi: 10.1111/bcpt.12790.

Vuorenpää Hanna, Penttinen Kirsi, Heinonen Tuula, Pekkanen-Mattila Mari, Sarkanen Jertta-Riina, Ylikomi Timo and Aalto-Setälä Katriina. Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes Is Improved in Cardiovascular Construct. Cytotechnology, 2017. 69(5), 785-800.

Senn P(1), Roccio M, Hahnewald S, Frick C, Kwiatkowska M, Ishikawa M, Bako P, Li H, Edin F, Liu W, Rask-Andersen H, Pyykkö I, Zou J, Mannerström M, Keppner H, Homsy A, Laux E, Llera M, Lellouche JP, Ostrovsky S, Banin E, Gedanken A, Perkas N, Wank U, Wiesmüller KH, Mistrík P, Benav H, Garnham C, Jolly C, Gander F, Ulrich P, Müller M, Löwenheim H. NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons. Otol Neurotol. 2017 Sep;38(8):e224-e231.

Toimela T, Huttala O, Sabell E, Mannerström M, Sarkanen JR, Ylikomi T, Heinonen T: Intra-laboratory validated human cell-based in vitro vasculogenesis/angiogenesis test with serum-free medium. Reproductive Toxicology, DOI: 10.1016/j.reprotox.2016.11.015, 2016.

Virtanen A, Toimela T, Tihtonen K, Sarkanen JR, Huttala O, Heinonen T and Uotila J: Strong inhibitory effect of preeclampsia serum on angiogenesis detected in vitro by human cell based angiogenesis  tests. DOI:10.1016/j.preghy.2016.08.239, 2016.

Huttala O, Mysore R, Sarkanen JR, Heinonen T, Olkkonen VM, Ylikomi T. Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes. Cell Tissue Res 366(1):63-74, 2016.

Gillian R. Langley, Ian Adcock, François Busquet, Kevin M. Crofton, Elena Csernok, Christoph Giese, Tuula Heinonen, Kathrin Herrmann, Martin Hofmann-Apitius, Brigitte Landesmann, Lindsay Marshall, Emily McIvor, Alysson Muotri, Fozia Noor, Katrin Schutte, Troy Seidle, Anja van de Stolpe, Hilde Van Esch, Catherine Willett, Grzegorz Woszczek. Towards a 21st-century roadmap for biomedical research and drug discovery: Consensus report and recommendations. Drug Discovery Today, November 2016. DOI  http://dx.doi.org/10.1016/j.drudis.2016.10.01

Mannerström M, Zou J, Toimela T, Pyykkö I, Heinonen T. The applicability of conventional cytotoxicity assays to predict safety/toxicity of mesoporous silica nanoparticles, silver and gold nanoparticles and multi-walled carbon nanotubes. Toxicology in Vitro 37:113-120, 2016. DOI:10.1016/j.tiv.2016.09.012.

Bondarenko OM, Heinlaan M, Sihtmäe M, Ivask A, Kurvet I, Joonas E, Jemec A, Mannerström M, Heinonen T, Rekulapelly R, Singh S, Zou J, Pyykkö I, Drobne D,    Kahru A. Multilaboratory evaluation of 15 bioassays for (eco)toxicity screening and hazard ranking of engineered nanomaterials: FP7 project NANOVALID. Nanotoxicology 10(9):1-45, 2016.

Laitinen Anita, Lampinen Milla, Liedtke Stefanie, Kilpinen Lotta, Kerkelä Erja, Sarkanen Jertta-Riina, Heinonen Tuula, Kögler Gesine, Laitinen Saara. The effects of culture conditions on the functionality of efficiently obtained mesenchymal stromal cells from human cord blood. Cytotherapy 18, 423-437, 2016 DOI: 10.1016/j.jcyt.2015.11.014.

Huttala O, Vuorenpää H, Toimela T, Uotila J, Kuokkanen H, Ylikomi T, Sarkanen JR, Heinonen T. Human vascular model with defined stimulation medium – A characterisation study. Altex 32(2):125-36, 2015.

Bal-Price Anna, Crofton Kevin M, Leist Marcel, Allen Sandra, Arand Michael Buetler Timo, Delrue Nathalie, FitzGerald Rex E, Hartung Thomas, Heinonen Tuula, Hogberg Helena, Bennekou Susanne H, Lichtensteiger Walter, Oggier Daniela, Paparella Martin, Axelstad Marta, Piersma Aldert, Rached Eva, Schilter Benoit, Schmuck Gabriele, Stoppini Luc, Tongiorgi Enrico, Tiramani Manuela, Monnet-Tschudi Florianne, Wilks Martin F, Ylikomi Timo, Fritsche Ellen. International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Arch Toxicol.89(2):269-87, 2015. doi: 10.1007/s00204-015-1464-2. Epub 2015 Jan 25.

Heinonen Tuula, Gaus Wilhelm. Cross matching observations on toxicological and clinical data for the assessment of tolerability and safety of Ginkgo biloba leaf extract. Toxicology. 327, 95–115, 2015. doi:10.1016/j.tox.2014.10.013

Heinonen Tuula. Better science with human cell-based organ and tissue models (Björn Ekwall Memorial Award Lecture). Atla, 43, 1-10, 2015.

Vuorenpaa H, Ikonen L, Kujala K, Huttala O, Sarkanen JR, Ylikomi T, Aalto-Setälä K, Heinonen T. Novel in vitro cardiovascular contructs composed of a vascular-like network and cardiomyocytes. In vitro Cellular & Molecular developmental biology- Animal 50(4):275-86, 2014.

Zou J, Feng H, Mannerström M, Heinonen T, Pyykkö I: Toxicity of silver nanoparticle in rat ear and BALB/c 3T3 cell line. Journal of Nanobiotechnology 12:52, 2014.

Knudsen Lisbeth E., Mathiesen Line,  Nielsen Jesper B, Tähti Hanna and Heinonen Tuula. Workshop of Scandinavian Society for Cell Toxicology 25-27 September 2013 in Denmark. Basic & Clinical Pharmacology & Toxicology, 2014, 115, 1-3.

Heinonen Tuula, Louekari Kimmo, Tähti Hanna. Need for harmonized strategies and improved assessment of carcinogenic and genotoxic potencies of chemical substances. Journal of Translational Toxicology. 1, 76-87, 2014.

Tuula Heinonen ja Hanna Tähti. Eläinkokeettomat menetelmät tutkimuksessa ja testauksessa. SIC! lääketietoa FIMEAsta 1/2014, sivut 42-45.

Heinonen T, Tähti H: Eläinkokeeton toksikologia kemikaalien turvallisuustestauksessa. Duodecim 129: 1686-94, 2013.

Heinonen T, Louekari K, Tähti H: Need for harmonized strategies and improved assessment of carcinogenic and genotoxic potencies of chemical substances. Journal of Translational Toxicology 1, 1-12, 2013.

Heinonen Tuula, Tähti Hanna, Vähäkangas Kirsi and Blaauboer Bas J. Towards toxicity assessment without animals. 28th workshop of SSCT and FINCOPA seminar 21-23 September 2011, Tampere, Finland (Editorial). Toxicology in Vitro. 27(5), 1563-1564, 2013.

Sarkanen JR, Vuorenpää H, Huttala O, Mannerström B, Kuokkanen H, Miettinen S, Heinonen T, Ylikomi T.: Adipose stromal cell tubule network model provides a versatile tool for vascular research and tissue engineering. Cells Tissues Organs. 196(5):385-97, 2012.

Sarkanen JR, Ruusuvuori P, Kuokkanen H, Paavonen T, Ylikomi T.: Bioactive acellular implant induces angiogenesis and adipogenesis and sustained soft tissue restoration in vivo. Tissue Eng Part A. 18(23-24):2568-80, 2012.

Sarkanen JR, Kaila V, Mannerström B, Räty S, Kuokkanen H, Miettinen S, Ylikomi T.: Human adipose tissue extract induces angiogenesis and adipogenesis in vitro. Tissue Eng Part A. 18(1-2):17-25, 2012.

Adler, S., Basketter, D., Creton, S., Pelkonen, O., van Benthem, J., Zuang, V., Andersen, K.E., Angers-Loustau, A., Aptula, A., Bal-Price, A., Benfenati, E., Bernauer, U., Bessems, J., Bois, F.Y., Boobis, A., Brandon, E., Bremer, S., Broschard, T., Casati, S., Coecke, S., Corvi, R., Cronin, M., Daston, G., Dekant, W., Felter, S., Grignard, E., Gundert-Remy, U., Heinonen, T., Kimber, I., Kleinjans, J., Komulainen, H., Kreiling, R., Kreysa, J., Leite, S.B., Loizou, G., Maxwell, G., Mazzatorta, P., Munn, S., Pfuhler, S., Phrakonkham, P., Piersma, A., Poth, A., Prieto, P., Repetto, G., Rogiers, V., Schoeters, G., Schwarz, M., Serafimova, R., Tahti, H., Testai, E., van Delft, J., van Loveren, H., Vinken, M., Worth, A., Zaldivar, J.M., 2011. Alternative (non-animal) methods for cosmetics testing: current status and future prospects. Arch. Toxicol. 85, 367-485, 2010

Tähti H, Heinonen T. Vaihtoehtoiset menetelmät kemikaalien turvallisuustestauksessa. Solubiologi No 2, 10-16, 2010.

Diallo H. Veri-aivoesteen mallintaminen in vitro. Solubiologis No 2, 17-21,2010.

Heinonen T, Mannerström M. Eläinkokeille vaihtoehtoisten testimenetelmien kehittäminen, optimointi ja validointi. Solubiologi No 2, 23-25, 2010.

Sarkanen JR, Heinonen T. In vitro-verisuonimallin validointi. Solubiologi No 2, 26-33, 2010.

Sarkanen JR, Mannerström M,Vuorenpää H, Uotila J,Ylikomi T, Heinonen T: Intra-Laboratory Pre-Validation of a Human Cell Based in vitro Angiogenesis Assay for Testing Angiogenesis Modulators. Front Pharmacol. 1: 147, 2010.

Tarkkanen AM, Heinonen T, Jõgi R, Mentula S, van der Rest ME, Donskey CJ, Kemppainen T, Gurbanov K & Nord CE : P1A recombinant beta-lactamase prevents emergence of antimicrobial resistance in gut microflora of healthy subjects during intravenous administration of ampicillin. Antimicrob Agents Chemother. 53(6):2455-2462, 2009.

Hallier-Vanuxeem D, Prieto P, Culot M, Diallo H, Landry C, Tähti H, Cecchelli R: New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment. Toxicol In Vitro. 23(3):447-453, 2009.

Nevala H, Ylikomi T & Tähti H: Evaluation of the barrier properties of ARPE-19 cell line for in vitro blood-brain barrier model. Hum Exp Toxicol 27(10):741-749, 2008.

Bläuer M, Tammela TL, Ylikomi T. A novel tissue-slice culture model for non-malignant human prostate. Cell Tissue Res. 332(3):489-498, 2008.

Toimela T, Tähti H & Ylikomi T: Comparison of automated pattern analysis machine vision time lapse system with traditional endpoint measurements in analyzing cell growth and cytotoxicity. ATLA 36:313-325, 2008.

Bläuer M, Heinonen PK, Rovio P & Ylikomi T: Effects of tamoxifen and raloxifene on normal human endometrial cells in an organotypic in vitro model. Eur J Pharmacol 592(1-3):13-18, 2008.

 Pärssinen J, Kuukasjärvi T, Karhu R & Kallioniemi A: High-level amplification at 17q23 leads to coordinated overexpression of multiple adjacent genes in breast cancer. Br J Cancer. 96(8):1258-1264, 2007

Sarkanen JR, Nykky J, Siikanen J, Selinummi J, Ylikomi T, & Jalonen, TO: Cholesterol supports the retinoic acid-induced synaptic vesicle formation in differentiating human SH-SY5Y neuroblastoma cells. J Neurochem 102(6):1941-1952, 2007.

 Alarmo EL, Rauta J, Kauraniemi P, Karhu R, Kuukasjärvi T & Kallioniemi A: Bone morphogenetic protein 7 is widely overexpressed in primary breast cancer. Genes Chromosomes Cancer. 45(4):411-419, 2006.

Mannerström M, Toimela T, Ylikomi T & Tähti H: The combined use of human neural and liver cell lines and mouse hepatocytes improves the predictability of the neurotoxicity of selected drugs. Toxicol Lett 165(2):195-202, 2006.

 Rauta J, Alarmo EL, Kauraniemi P, Karhu R, Kuukasjärvi T & Kallioniemi A: The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours. Breast Cancer Res Treat. 95(3):257-263, 2006.

Selinummi J, Sarkanen JR, Niemistö A, Linne ML, Ylikomi T, Yli-Harja O & Jalonen TO: Quantification of vesicles in differentiating human SH-SY5Y neuroblastoma cells by automated image analysis. Neurosci Lett 396(2):102-107, 2006.

 Bläuer M, Heinonen PK, Martikainen PM, Tomas E & Ylikomi T: A novel organotypic culture model for normal human endometrium: regulation of epithelial cell proliferation by estradiol and medroxyprogesterone acetate. Hum Reprod 20:864-871, 2005.

Mannerstöm M & Tähti H: Glucose-uptake as a target of neurological drugs in glial and neuronal cell lines. Toxicol Lett, 151, 87-97, 2004.

 Toimela T & Tähti H: Mitochondrial viability and apoptosis induced by aluminum, mercury and methylmercury in cell lines of neural origin. Arch Toxicol, 78, 565-574, 2004.

Kakko I, Toimela T & Tähti H: The toxicity of pyrethroid compounds in neural cell cultures studied with total ATP, mitochondrial enzyme activity and microscopic photographing. Environ Toxicol Pharmacol 15, 95-102, 2004.

 Kakko I, Toimela T &Tähti H: Oestradiol potentiates the effect of certain pyrethroid compounds in the MCF-7 human breast carcinoma cell line. Altern Lab. Anim. ATLA, 32, 383-390, 2004.

Mannerström M & Tähti H: Modulation of glucose uptake in glial and neuronal cell lines by selected neurological drugs. Toxicol Lett. 151(1):87-97, 2004.

 Toimela T, Mäenpää H, Mannerström M & Tähti H: Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicol Appl Pharmacol. 195(1):73-82, 2004.

Mäenpää H, Toimela T, Mannerström M, Saransaari P & Tähti H: Toxicity of selected cationic drugs in retinoblastomal cultures and in cocultures of retinoblastomal and retinal pigment epithelial cell lines. Neurochem Res. 29(1):305-11, 2004.

 Szabó A, Varga V, Toimela T, Hiitelä K, Tähti H, Oja SS, Süveges I & Salminen L: Laser treatment of cultured retinal pigment epithelial cells-evaluation of the cellular damage in vitro. J Ocul Pharmacol Ther. 20(3):246-255, 2004.