Group leader:
Prof. Terho Lehtimäki

Group page:
https://research.uta.fi/clinical-chemistry/

Latest publications:

2020

Ochoa-Rosales C, Portilla-Fernandez E, Nano J, Wilson R, Lehne B, Mishra PP, Gao X, Ghanbari M, Rueda-Ochoa OL, Juvinao-Quintero D, Loh M, Zhang W, Kooner JS, Grabe HJ, Felix SB, Schöttker B, Zhang Y, Gieger C, Müller-Nurasyid M, Heier M, Peters A, Lehtimäki T, Teumer A, Brenner H, Waldenberger M, Ikram MA, van Meurs JBJ, Franco OH, Voortman T, Chambers J, Stricker BH, Muka T
Epigenetic Link Between Statin Therapy and Type 2 Diabetes.
Diabetes Care ;2020
PMID

Traylor M, Amin Al Olama A, Lyytikäinen LP, Marini S, Chung J, Malik R, Dichgans M, Kähönen M, Lehtimäki T, Anderson CD, Raitakari OT, Markus HS
Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke.
Hypertension ;75(2)365-371, 2020
PMID

Ekholm J, Ohukainen P, Kangas AJ, Kettunen J, Wang Q, Karsikas M, Khan AA, Kingwell BA, Kähönen M, Lehtimäki T, Raitakari OT, Järvelin MR, Meikle PJ, Ala-Korpela M
EpiMetal: an open-source graphical web browser tool for easy statistical analyses in epidemiology and metabolomics.
Int J Epidemiol ;2020
PMID

Koskinen JS, Kytö V, Juonala M, Viikari JSA, Nevalainen J, Kähönen M, Lehtimäki T, Hutri-Kähönen N, Laitinen T, Tossavainen P, Jokinen E, Magnussen CG, Raitakari OT
Childhood risk factors and carotid atherosclerotic plaque in adulthood: The Cardiovascular Risk in Young Finns Study.
Atherosclerosis ;2020
PMID

Mishra BH, Mishra PP, Mononen N, Hilvo M, Sievänen H, Juonala M, Laaksonen M, Hutri-Kähönen N, Viikari J, Kähönen M, Raitakari OT, Laaksonen R, Lehtimäki T
Lipidomic architecture shared by subclinical markers of osteoporosis and atherosclerosis: The Cardiovascular Risk in Young Finns Study.
Bone ;2020
PMID

Saarinen AIL, Keltikangas-Järvinen L, Lehtimäki T, Jula A, Cloninger CR, Hintsanen M
Somatic complaints in early adulthood predict the developmental course of compassion into middle age.
J Psychosom Res ;2020
PMID

Laitinen TT, Vahtera J, Pahkala K, Magnussen CG, Nuotio J, Hutri-Kähönen N, Kivimäki M, Lehtimäki T, Jokinen E, Laitinen T, Tossavainen P, Pentti J, Viikari JSA, Juonala M, Raitakari OT
Childhood Socioeconomic Disadvantage and Risk of Fatty Liver in Adulthood: The Cardiovascular Risk in Young Finns Study.
Hepatology ;71(1)67-75, 2020
PMID

2019

Juonala M, Pitkänen N, Tolonen S, Laaksonen M, Sievänen H, Jokinen E, Laitinen T, Sabin MA, Hutri-Kähönen N, Lehtimäki T, Taittonen L, Jula A, Loo BM, Impivaara O, Kähönen M, Magnussen CG, Viikari JSA, Raitakari OT
Childhood exposure to passive smoking and bone health in adulthood. The Cardiovascular Risk in Young Finns Study.
J Clin Endocrinol Metab ;2019
PMID

Savolainen AM, Karmi A, Immonen H, Soinio M, Saunavaara V, Pham T, Salminen P, Helmiö M, Ovaska J, Löyttyniemi E, Heiskanen MA, Lehtimäki T, Mari A, Nuutila P, Hannukainen JC
Physical Activity Associates with Muscle Insulin Sensitivity Postbariatric Surgery.
Med Sci Sports Exerc ;51(2)278-287, 2019
PMID

Lea A, Subramaniam M, Ko A, Lehtimäki T, Raitoharju E, Kähönen M, Seppälä I, Mononen N, Raitakari OT, Ala-Korpela M, Pajukanta P, Zaitlen N, Ayroles JF
Genetic and environmental perturbations lead to regulatory decoherence.
Elife ;2019
PMID

Dobewall H, Savelieva K, Seppälä I, Knafo-Noam A, Hakulinen C, Elovainio M, Keltikangas-Järvinen L, Pulkki-Råback L, Raitakari OT, Lehtimäki T, Hintsanen M
Gene-environment correlations in parental emotional warmth and intolerance: genome-wide analysis over two generations of the Young Finns Study.
J Child Psychol Psychiatry ;60(3)277-285, 2019
PMID

van Setten J, Verweij N, Mbarek H, Niemeijer MN, Trompet S, Arking DE, Brody JA, Gandin I, Grarup N, Hall LM, Hemerich D, Lyytikäinen LP, Mei H, Müller-Nurasyid M, Prins BP, Robino A, Smith AV, Warren HR, Asselbergs FW, Boomsma DI, Caulfield MJ, Eijgelsheim M, Ford I, Hansen T, Harris TB, Heckbert SR, Hottenga JJ, Iorio A, Kors JA, Linneberg A, MacFarlane PW, Meitinger T, Nelson CP, Raitakari OT, Silva Aldana CT, Sinagra G, Sinner M, Soliman EZ, Stoll M, Uitterlinden A, van Duijn CM, Waldenberger M, Alonso A, Gasparini P, Gudnason V, Jamshidi Y, Kääb S, Kanters JK, Lehtimäki T, Munroe PB, Peters A, Samani NJ, Sotoodehnia N, Ulivi S, Wilson JG, de Geus EJC, Jukema JW, Stricker B, van der Harst P, de Bakker PIW, Isaacs A
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
Eur J Hum Genet ;2019
PMID

Sivertsen EA, Haug KBF, Kristianslund EK, Trøseid AS, Parkkari J, Lehtimäki T, Mononen N, Pasanen K, Bahr R
No Association Between Risk of Anterior Cruciate Ligament Rupture and Selected Candidate Collagen Gene Variants in Female Elite Athletes From High-Risk Team Sports.
Am J Sports Med ;47(1)52-58, 2019
PMID

Salokari E, Laukkanen JA, Lehtimaki T, Kurl S, Kunutsor S, Zaccardi F, Viik J, Lehtinen R, Nikus K, Kööbi T, Turjanmaa V, Kähönen M, Nieminen T
The Duke treadmill score with bicycle ergometer: Exercise capacity is the most important predictor of cardiovascular mortality.
Eur J Prev Cardiol ;26(2)199-207, 2019
PMID

Dörr M, Hamburg NM, Müller C, Smith NL, Gustafsson S, Lehtimäki T, Teumer A, Zeller T, Li X, Lind L, Raitakari OT, Völker U, Blankenberg S, McKnight B, Morris AP, Kähönen M, Lemaitre RN, Wild PS, Nauck M, Völzke H, Münzel T, Mitchell GF, Psaty BM, Lindgren CM, Larson MG, Felix SB, Ingelsson E, Lyytikäinen LP, Herrington D, Benjamin EJ, Schnabel RB
Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation.
Circ Genom Precis Med ;12(2)e002409, 2019
PMID

Pyysalo MJ, Mishra PP, Sundström K, Lehtimäki T, Karhunen PJ, Pessi T
Increased tooth brushing frequency is associated with reduced gingival pocket bacterial diversity in patients with intracranial aneurysms.
PeerJ ;2019
PMID

Karjalainen JP, Mononen N, Hutri-Kähönen N, Lehtimäki M, Juonala M, Ala-Korpela M, Kähönen M, Raitakari O, Lehtimäki T
The effect of apolipoprotein E polymorphism on serum metabolome - a population-based 10-year follow-up study.
Sci Rep ;9(1)458, 2019
PMID

Wu F, Juonala M, Pahkala K, Buscot MJ, Sabin MA, Pitkänen N, Rönnemaa T, Jula A, Lehtimäki T, Hutri-Kähönen N, Kähönen M, Laitinen T, Viikari JSA, Raitakari OT, Magnussen CG
Youth and long-term dietary calcium intake with risk of impaired glucose metabolism and type 2 diabetes in adulthood.
J Clin Endocrinol Metab ;2019
PMID

Laaksonen J, Seppälä I, Raitoharju E, Mononen N, Lyytikäinen LP, Waldenberger M, Illig T, Lepistö M, Almusa H, Ellonen P, Hutri-Kähönen N, Juonala M, Kähönen M, Raitakari O, Salonen JT, Lehtimäki T
Discovery of mitochondrial DNA variants associated with genome-wide blood cell gene expression: a population-based mtDNA sequencing study.
Hum Mol Genet ;2019
PMID

Nissinen SI, Roine A, Hokkinen L, Karjalainen M, Venäläinen M, Helminen H, Niemi R, Lehtimäki T, Rantanen T, Oksala N
Detection of Pancreatic Cancer by Urine Volatile Organic Compound Analysis.
Anticancer Res ;39(1)73-79, 2019
PMID

Vähämurto L, Pahkala K, Magnussen CG, Hutri-Kähönen N, Kähönen M, Laitinen T, Taittonen L, Tossavainen P, Lehtimäki T, Jokinen E, Telama R, Rönnemaa T, Viikari J, Juonala M, Raitakari OT
Coronary heart disease risk factor levels in eastern and western Finland from 1980 to 2011 in the cardiovascular risk in Young Finns study.
Atherosclerosis ;2019
PMID

Böckerman P, Cawley J, Viinikainen J, Lehtimäki T, Rovio S, Seppälä I, Pehkonen J, Raitakari O
The effect of weight on labor market outcomes: An application of genetic instrumental variables.
Health Econ ;28(1)65-77, 2019
PMID