Group leader:
Prof. Katriina Aalto-Setälä

The main aim of heart group is to differentiate functional cardiomyocytes and hepatocytes from pluripotent stem cells and study different genetic heart diseases and atherosclerosis with the help of induced pluripotent stem cell (iPSC) technology.

Home pages:
https://research.uta.fi/heart-group/

http://www.biomeditech.fi/research/heart-group/

Latest publications:

2020

Kreutzer J, Viehrig M, Pölönen RP, Zhao F, Ojala M, Aalto-Setälä K, Kallio P
Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes.
Biomech Model Mechanobiol ;19(1)291-303, 2020
PMID

Calejo MT, Saari J, Vuorenpää H, Vuorimaa-Laukkanen E, Kallio P, Aalto-Setälä K, Miettinen S, Skottman H, Kellomäki M, Juuti-Uusitalo K
Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films.
Acta Biomater ;2020
PMID

Pölönen RP, Swan H, Aalto-Setälä K
Mutation-specific differences in arrhythmias and drug responses in CPVT patients: simultaneous patch clamp and video imaging of iPSC derived cardiomyocytes.
Mol Biol Rep ;47(2)1067-1077, 2020
PMID

Heliö K, Kangas-Kontio T, Weckström S, Vanninen SUM, Aalto-Setälä K, Alastalo TP, Myllykangas S, Heliö TM, Koskenvuo JW
DSP p.(Thr2104Glnfs*12) variant presents variably with early onset severe arrhythmias and left ventricular cardiomyopathy.
BMC Med Genet ;21(1)19, 2020
PMID

2019

Kim J, Shah D, Potapov I, Latukka J, Aalto-Setälä K, Räsänen E
Scaling and correlation properties of RR and QT intervals at the cellular level.
Sci Rep ;9(1)3651, 2019
PMID

Viiri LE, Rantapero T, Kiamehr M, Alexanova A, Oittinen M, Viiri K, Niskanen H, Nykter M, Kaikkonen MU, Aalto-Setälä K
Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation.
Sci Rep ;9(1)3562, 2019
PMID

Kiamehr M, Alexanova A, Viiri LE, Heiskanen L, Vihervaara T, Kauhanen D, Ekroos K, Laaksonen R, Käkelä R, Aalto-Setälä K
hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver.
J Cell Physiol ;234(4)3744-3761, 2019
PMID