Publications

2024

  1. Komulainen, T, Daymond, P, Hietanen, KE, Kaartinen, IS, Järvinen, TAH. Myofibroblasts reside in the middle dermis of the keloids but do not predict the response to injection therapies: a double-blinded, randomized, controlled trial. Front Med (Lausanne). 2024;11 :1293028. doi: 10.3389/fmed.2024.1293028. PubMed PMID:38495113 PubMed Central PMC10943694.
  2. Maldonado, H, Savage, BD, Barker, HR, May, U, Vähätupa, M, Badiani, RK et al.. Author Correction: Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function. Nat Commun. 2024;15 (1):234. doi: 10.1038/s41467-023-44574-4. PubMed PMID:38172142 PubMed Central PMC10764947.

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2023

  1. Maldonado, H, Savage, BD, Barker, HR, May, U, Vähätupa, M, Badiani, RK et al.. Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function. Nat Commun. 2023;14 (1):8069. doi: 10.1038/s41467-023-43848-1. PubMed PMID:38057316 PubMed Central PMC10700342.
  2. Edouard, P, Reurink, G, Mackey, AL, Lieber, RL, Pizzari, T, Järvinen, TAH et al.. Traumatic muscle injury. Nat Rev Dis Primers. 2023;9 (1):56. doi: 10.1038/s41572-023-00469-8. PubMed PMID:37857686 .
  3. Salomaa, T, Kummola, L, González-Rodríguez, MI, Hiihtola, L, Järvinen, TAH, Junttila, IS et al.. Low IL-13Rα1 expression on mast cells tunes them unresponsive to IL-13. J Leukoc Biol. 2023;114 (2):187-194. doi: 10.1093/jleuko/qiad065. PubMed PMID:37224625 .
  4. Vähätupa, M, Nättinen, J, Aapola, U, Uusitalo-Järvinen, H, Uusitalo, H, Järvinen, TAH et al.. Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy. Int J Mol Sci. 2023;24 (9):. doi: 10.3390/ijms24097914. PubMed PMID:37175621 PubMed Central PMC10178533.
  5. Ojanen, MJT, Caro, FM, Aittomäki, S, Ploquin, MJ, Ortutay, Z, Pekkarinen, M et al.. FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice. Eur J Immunol. 2023;53 (6):e2250246. doi: 10.1002/eji.202250246. PubMed PMID:37015057 .

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2022

  1. Valle, X, Mechó, S, Alentorn-Geli, E, Järvinen, TAH, Lempainen, L, Pruna, R et al.. Return to Play Prediction Accuracy of the MLG-R Classification System for Hamstring Injuries in Football Players: A Machine Learning Approach. Sports Med. 2022;52 (9):2271-2282. doi: 10.1007/s40279-022-01672-5. PubMed PMID:35610405 .
  2. Coentro, JQ, di Nubila, A, May, U, Prince, S, Zwaagstra, J, Järvinen, TAH et al.. Dual drug delivery collagen vehicles for modulation of skin fibrosis. Biomed Mater. 2022;17 (2):. doi: 10.1088/1748-605X/ac5673. PubMed PMID:35176732 .
  3. Salomaa, T, Pemmari, T, Määttä, J, Kummola, L, Salonen, N, González-Rodríguez, M et al.. IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells. J Invest Dermatol. 2022;142 (6):1565-1575.e17. doi: 10.1016/j.jid.2021.11.013. PubMed PMID:34808240 .

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2021

  1. Vähätupa, M, Salonen, N, Uusitalo-Järvinen, H, Järvinen, TAH. Selective Targeting and Tissue Penetration to the Retina by a Systemically Administered Vascular Homing Peptide in Oxygen Induced Retinopathy (OIR). Pharmaceutics. 2021;13 (11):. doi: 10.3390/pharmaceutics13111932. PubMed PMID:34834347 PubMed Central PMC8618640.
  2. Salomaa, T, Pemmari, T, Määttä, J, Kummola, L, Salonen, N, González-Rodríguez, M et al.. IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells. J Invest Dermatol. 2022;142 (6):1565-1575.e17. doi: 10.1016/j.jid.2021.11.013. PubMed PMID:34808240 .
  3. Coentro, JQ, May, U, Prince, S, Zwaagstra, J, Ritvos, O, Järvinen, TAH et al.. Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies. Front Bioeng Biotechnol. 2021;9 :756399. doi: 10.3389/fbioe.2021.756399. PubMed PMID:34765594 PubMed Central PMC8576412.
  4. Iqbal, A, May, U, Prince, SN, Järvinen, TAH, Heydemann, A. Systemically Administered Homing Peptide Targets Dystrophic Lesions and Delivers Transforming Growth Factor-β (TGFβ) Inhibitor to Attenuate Murine Muscular Dystrophy Pathology. Pharmaceutics. 2021;13 (9):. doi: 10.3390/pharmaceutics13091506. PubMed PMID:34575582 PubMed Central PMC8471674.
  5. Contreras-Muñoz, P, Torrella, JR, Venegas, V, Serres, X, Vidal, L, Vila, I et al.. Muscle Precursor Cells Enhance Functional Muscle Recovery and Show Synergistic Effects With Postinjury Treadmill Exercise in a Muscle Injury Model in Rats. Am J Sports Med. 2021;49 (4):1073-1085. doi: 10.1177/0363546521989235. PubMed PMID:33719605 .
  6. De Rossi, G, Vähätupa, M, Cristante, E, Arokiasamy, S, Liyanage, SE, May, U et al.. Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization. Arterioscler Thromb Vasc Biol. 2021;41 (4):1374-1389. doi: 10.1161/ATVBAHA.121.315941. PubMed PMID:33596666 PubMed Central PMC7613699.

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2020

  1. Pemmari, T, Laakso, J, Patrikainen, MS, Parkkila, S, Järvinen, TAH. Carbonic Anhydrase VI in Skin Wound Healing Study on Knockout Mice. Int J Mol Sci. 2020;21 (14):. doi: 10.3390/ijms21145092. PubMed PMID:32708518 PubMed Central PMC7404312.
  2. Vähätupa, M, Järvinen, TAH, Uusitalo-Järvinen, H. Exploration of Oxygen-Induced Retinopathy Model to Discover New Therapeutic Drug Targets in Retinopathies. Front Pharmacol. 2020;11 :873. doi: 10.3389/fphar.2020.00873. PubMed PMID:32595503 PubMed Central PMC7300227.
  3. Pemmari, T, Ivanova, L, May, U, Lingasamy, P, Tobi, A, Pasternack, A et al.. Exposed CendR Domain in Homing Peptide Yields Skin-Targeted Therapeutic in Epidermolysis Bullosa. Mol Ther. 2020;28 (8):1833-1845. doi: 10.1016/j.ymthe.2020.05.017. PubMed PMID:32497513 PubMed Central PMC7403337.
  4. Study Group of the Muscle and Tendon System from the Spanish Society of Sports Traumatology, Balius, R, Blasi, M, Pedret, C, Alomar, X, Peña-Amaro, J et al.. A Histoarchitectural Approach to Skeletal Muscle Injury: Searching for a Common Nomenclature. Orthop J Sports Med. 2020;8 (3):2325967120909090. doi: 10.1177/2325967120909090. PubMed PMID:32232071 PubMed Central PMC7092384.
  5. Hietanen, KE, Järvinen, TAH, Huhtala, H, Tolonen, TT, Kaartinen, IS. Histopathology and immunohistochemical analysis of 5-fluorouracil and triamcinolone treated keloids in double-blinded randomized controlled trial. Wound Repair Regen. 2020;28 (3):385-399. doi: 10.1111/wrr.12803. PubMed PMID:32112591 .
  6. Järvinen, TAH, Pemmari, T. Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine. Nanomaterials (Basel). 2020;10 (2):. doi: 10.3390/nano10020226. PubMed PMID:32013041 PubMed Central PMC7075297.

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2019

  1. Vähätupa, M, Pemmari, T, Junttila, I, Pesu, M, Järvinen, TAH. Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA). J Vis Exp. 2019; (154):. doi: 10.3791/60445. PubMed PMID:31904021 .
  2. Ketomäki, T, Vähätupa, M, May, U, Pemmari, T, Ruikka, E, Hietamo, J et al.. R-Ras regulates vascular permeability, but not overall healing in skin wounds. Exp Dermatol. 2019;28 (2):202-206. doi: 10.1111/exd.13851. PubMed PMID:30489650 .
  3. Järvinen, TAH, Ruoslahti, E. Generation of a multi-functional, target organ-specific, anti-fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin. Br J Pharmacol. 2019;176 (1):16-25. doi: 10.1111/bph.14374. PubMed PMID:29847688 PubMed Central PMC6284330.

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2018

  1. Ketomäki, T, Vähätupa, M, May, U, Pemmari, T, Ruikka, E, Hietamo, J et al.. R-Ras regulates vascular permeability, but not overall healing in skin wounds. Exp Dermatol. 2019;28 (2):202-206. doi: 10.1111/exd.13851. PubMed PMID:30489650 .
  2. Vähätupa, M, Nättinen, J, Jylhä, A, Aapola, U, Kataja, M, Kööbi, P et al.. SWATH-MS Proteomic Analysis of Oxygen-Induced Retinopathy Reveals Novel Potential Therapeutic Targets. Invest Ophthalmol Vis Sci. 2018;59 (8):3294-3306. doi: 10.1167/iovs.18-23831. PubMed PMID:30025079 .
  3. Järvinen, TAH, Ruoslahti, E. Generation of a multi-functional, target organ-specific, anti-fibrotic molecule by molecular engineering of the extracellular matrix protein, decorin. Br J Pharmacol. 2019;176 (1):16-25. doi: 10.1111/bph.14374. PubMed PMID:29847688 PubMed Central PMC6284330.
  4. Schneider, M, Angele, P, Järvinen, TAH, Docheva, D. Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing. Adv Drug Deliv Rev. 2018;129 :352-375. doi: 10.1016/j.addr.2017.12.016. PubMed PMID:29278683 .
  5. Vähätupa, M, Cordova, ZM, Barker, H, Aittomäki, S, Uusitalo, H, Järvinen, TAH et al.. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018;166 :160-167. doi: 10.1016/j.exer.2017.10.013. PubMed PMID:29031855 .
  6. Sihvonen, R, Paavola, M, Malmivaara, A, Itälä, A, Joukainen, A, Nurmi, H et al.. Arthroscopic partial meniscectomy versus placebo surgery for a degenerative meniscus tear: a 2-year follow-up of the randomised controlled trial. Ann Rheum Dis. 2018;77 (2):188-195. doi: 10.1136/annrheumdis-2017-211172. PubMed PMID:28522452 PubMed Central PMC5867417.

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2017

  1. Schneider, M, Angele, P, Järvinen, TAH, Docheva, D. Rescue plan for Achilles: Therapeutics steering the fate and functions of stem cells in tendon wound healing. Adv Drug Deliv Rev. 2018;129 :352-375. doi: 10.1016/j.addr.2017.12.016. PubMed PMID:29278683 .
  2. Shen, Y, Russo, V, Zeglinski, MR, Sellers, SL, Wu, Z, Oram, C et al.. Recombinant Decorin Fusion Protein Attenuates Murine Abdominal Aortic Aneurysm Formation and Rupture. Sci Rep. 2017;7 (1):15857. doi: 10.1038/s41598-017-16194-8. PubMed PMID:29158532 PubMed Central PMC5696466.
  3. Vähätupa, M, Cordova, ZM, Barker, H, Aittomäki, S, Uusitalo, H, Järvinen, TAH et al.. Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy. Exp Eye Res. 2018;166 :160-167. doi: 10.1016/j.exer.2017.10.013. PubMed PMID:29031855 .
  4. Järvinen, TAH, Rashid, J, Valmari, T, May, U, Ahsan, F. Systemically Administered, Target-Specific Therapeutic Recombinant Proteins and Nanoparticles for Regenerative Medicine. ACS Biomater Sci Eng. 2017;3 (7):1273-1282. doi: 10.1021/acsbiomaterials.6b00746. PubMed PMID:33440515 .
  5. Sihvonen, R, Paavola, M, Malmivaara, A, Itälä, A, Joukainen, A, Nurmi, H et al.. Arthroscopic partial meniscectomy versus placebo surgery for a degenerative meniscus tear: a 2-year follow-up of the randomised controlled trial. Ann Rheum Dis. 2018;77 (2):188-195. doi: 10.1136/annrheumdis-2017-211172. PubMed PMID:28522452 PubMed Central PMC5867417.
  6. Kummola, L, Ortutay, Z, Vähätupa, M, Prince, S, Uusitalo-Järvinen, H, Järvinen, TAH et al.. R-Ras deficiency does not affect papain-induced IgE production in mice. Immun Inflamm Dis. 2017;5 (3):280-288. doi: 10.1002/iid3.168. PubMed PMID:28497586 PubMed Central PMC5569372.
  7. Contreras-Muñoz, P, Torrella, JR, Serres, X, Rizo-Roca, D, De la Varga, M, Viscor, G et al.. Postinjury Exercise and Platelet-Rich Plasma Therapies Improve Skeletal Muscle Healing in Rats But Are Not Synergistic When Combined. Am J Sports Med. 2017;45 (9):2131-2141. doi: 10.1177/0363546517702864. PubMed PMID:28453295 .

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